Category: 53710-78-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 53710-78-4

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

The synthetic route of 53710-78-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H9ClN2

1-(3-Chloropropyl)-1H-imidazole (596 mg, 4.12 mmol), potassium carbonate (660 mg, 4.775 mmol) and potassium iodide (106 mg, 0.64 mmol) were added to a stirred solution of cis-4-amino-5-chloro-2-methoxy-N-(3-methoxypiperidin-4-yl)benzamide (1 g, 3.188 mmol) in N,N-dimethylformamide (20 mL) in order. The reaction mixture was heated to 90 C for 12 h and then cooled to room temperature and extracted with ethyl acetate and water. The organic layer was dried over anhydrous MgSO4 and evaporated in vacuo. The residue was purified by column chromatography (chloroform:acetone = 4:1) to obtain the target compound (700 mg, 52% yield). 1H NMR (400 MHz, CDCl3): delta 8.19 (d, J = 8.4 Hz, 1H), 8.06 (s, 1H), 7.49 (s, 1H), 7.03 (s, 1H), 6.92 (s, 1H), 6.28 (s, 1H), 4.49 (bs, 2H), 4.19-4.08 (m, 1H), 4.08-3.92 (m, 2H), 3.85 (s, 3H), 3.44-3.38 (m, 4H), 2.99-2.83 (m, 1H), 2.78-2.65 (m, 1H), 2.35-2.18 (m, 2H), 2.18-2.03 (m, 2H), 1.99-1.67 (m, 4H). 13C NMR (400 MHz, CDCl3): delta 163.75, 157.56, 146.76, 137.41, 132.92, 129.28, 112.45, 111.44, 97.85, 57.14, 55.96, 54.19, 53.74, 51.44, 48.15, 44.53, 28.14, 27.73. HRMS (FAB): calcd for C20H28ClN5O3 [M+H]+ 422.1954, found 422.1955.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 53710-78-4.

Reference:
Article; Park, Jung Sang; Im, Weonbin; Choi, Sunghak; Park, Sook Jin; Jung, Jun Min; Baek, Ki Seon; Son, Han Pyo; Sharma, Satyasheel; Kim, In Su; Jung, Young Hoon; European Journal of Medicinal Chemistry; vol. 109; (2016); p. 75 – 88;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 53710-78-4, The chemical industry reduces the impact on the environment during synthesis 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.

General procedure: To a solution of 24 (53 mg, 0.1 mmol) in DMF (25 mL), 60% NaH (4.2 mg, 0.105 mmol) was added portionwise at room temperature. After stirring for 30 min, alkyl halide (0.15 mmol) was added and the mixture was then reacted at 80 C for 10h. After cooling, the mixture was poured into water (100 mL) and extracted with ethyl acetate (3×50mL). The organic phase was combined, washed with brine (3×100mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 28d and 28e.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ye, Qing; Shen, Yanhong; Zhou, Yubo; Lv, Dan; Gao, Jianrong; Li, Jia; Hu, Yongzhou; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 361 – 371;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 53710-78-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53710-78-4 as follows. Product Details of 53710-78-4

General procedure: 60% NaH (0.23 mmol) was added to a solution of 6a (0.23 mmol) in dry DMF (15 mL) at 0-5C. After stirring for 15 min at room temperature. 1-(3-chloropropyl)-1H-imidazole or 1-(4-chlorobutyl)-1H-imidazole (0.34 mmol) was added and stirred for 12 h at 60-65 C. After cooling, the mixture was poured into H2O (120 mL) and the resulting solution was extracted with ethyl acetate (60 mL × 3). The organic phase was combined, washed with brine (180 mL× 3), dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel using petroleum ether/ethyl acetate/MeOH (5:10:1, v/v) as eluent to afford 7d or 7e.

According to the analysis of related databases, 53710-78-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Hu, Yuanyuan; Ruan, Wenchen; Gao, Anhui; Zhou, Yubo; Gao, Lixin; Xu, Meng; Gao, Jianrong; Ye, Qing; Li, Jia; Pang, Tao; Pharmazie; vol. 72; 12; (2017); p. 707 – 713;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 53710-78-4, These common heterocyclic compound, 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Necked flask was added 100mg (0.24mmol) compound 3a and 10mL anhydrous DMF,Was added 9.6mg (0.24mmol) 60% NaH was dissolved with stirring,Stirred at room temperature 30min,Was then added 52mg (0.36mmol) 1- (3- chloropropyl) lH-imidazole,The reaction temperature was raised to 80 5H, the reaction was complete, the reaction was poured into 200mL of water,Extracted with ethyl acetate (50mL × 3), the combined organic layers washed with brine (150mL × 3), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (dichloromethane: methanol: triethylamine = 120: 4: 1, v / v / v) to afford 64.4mg 3i red solid, yield 51.0%

The synthetic route of 53710-78-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University; Shanghai Institute of Materia Medica; Ye, Qing; Li, Jia; Zhou, Yubo; Gao, Anhui; Gao, Lixin; Hu, Yuanyuan; Li, Xue; Gao, Jianrong; (17 pag.)CN105777751; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 53710-78-4, The chemical industry reduces the impact on the environment during synthesis 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, I believe this compound will play a more active role in future production and life.

General procedure: mmol), ethyl chloroacetate (0.147 g, 2.4 mmol), K2CO3(0.28 g,4 mmol) and DMF(10 ml) was stirred at 6 C for 12 h. DMF wasremoved under reduced pressure and the residue was purifiedthrough a column chromatography on silica with chloroform/methanol (V:V 50:1) as a white solid (0.59 g, 95.2% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(3-Chloropropyl)-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fan, Yan-Hua; Li, Wei; Liu, Dan-Dan; Bai, Meng-Xuan; Song, Hong-Rui; Xu, Yong-Nan; Lee, SangKook; Zhou, Zhi-Peng; Wang, Jian; Ding, Huai-Wei; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 95 – 106;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(3-Chloropropyl)-1H-imidazole

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 53710-78-4

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

The synthetic route of 53710-78-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 53710-78-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 60% NaH (9.6mg, 0.24mmol) was added to a solution of 5a (100mg, 0.24mmol) in dry DMF (10mL) at room temperature. After stirring for 30min, 1-(3-chloropropyl)-1H-imidazole (52mg, 0.36mmol) was added and the mixture was then stirred for 5h at 80C. After cooling, the mixture was poured into cold water (200mL) and extracted with EtOAc (3×50mL). The combined organic phase was washed with brine (3×150mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using dichloromethane/ 20 methanol/triethylamine (120:4:1, v/v/v) as eluent to afford 64.4mg (51.0%) 6a as a red solid.

The chemical industry reduces the impact on the environment during synthesis 1-(3-Chloropropyl)-1H-imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Liu, Xiaoqi; Hu, Yuanyuan; Gao, Anhui; Xu, Meng; Gao, Lixin; Xu, Lei; Zhou, Yubo; Gao, Jianrong; Ye, Qing; Li, Jia; Bioorganic and Medicinal Chemistry; vol. 27; 4; (2019); p. 589 – 603;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem