Category: 53484-18-7

Application of 53484-18-7, These common heterocyclic compound, 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1 (50 mg, 0.28 mmol), tert-butyl 2-amino-4-(thiophen-2- yl)phenylcarbamate (66 mg, 0.23 mmol), and EDCI (164 mg, 0.85 mmol) were combined in Py (3 ml_). The reaction was stirred at rt overnight. After completed, the mixture was concentrated and washed with water and ether. The white solid was afforded as Compound 2 (100 mg, 72%).

The synthetic route of 53484-18-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REGENACY PHARMACEUTICALS, LLC; VAN DUZER, John, H.; MAZITSCHEK, Ralph; BLUM, Charles; (70 pag.)WO2020/68950; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53484-18-7, Computed Properties of C9H8N2O2

Oxalyl chloride (42 mu, 0.47 mmol, 1.7 eq) was added dropwise to a mixture of 1- methyl-lH-benzo[d]imidazole-6-carboxylic acid (50 mg, 0.28 mmol, 1.0 eq) and DMF (2 mu, 0.03 mmol, 0.1 eq) in DCM (0.8 mL). The reaction was stirred at rt for 2 hrs. The reaction was concentrated under reduced pressure to give crude l-methyl-lH-benzo[d]imidazole-6- carbonyl chloride as a yellow residue that was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENANTA PHARMACEUTICALS INC; GRANGER, Brett; WANG, Gouqiang; SHEN, Ruichao; MA, Jun; XING, Xuechao; HE, Jing; HE, Yong; LONG, Jiang; WANG, Bin; OR, Yat, Sun; (108 pag.)WO2018/218044; (2018); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 53484-18-7, These common heterocyclic compound, 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1 (50 mg, 0.28 mmol), tert-butyl 2-amino-4-(thiophen-2- yl)phenylcarbamate (66 mg, 0.23 mmol), and EDCI (164 mg, 0.85 mmol) were combined in Py (3 ml_). The reaction was stirred at rt overnight. After completed, the mixture was concentrated and washed with water and ether. The white solid was afforded as Compound 2 (100 mg, 72%).

The synthetic route of 53484-18-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REGENACY PHARMACEUTICALS, LLC; VAN DUZER, John, H.; MAZITSCHEK, Ralph; BLUM, Charles; (70 pag.)WO2020/68950; (2020); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 53484-18-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53484-18-7, name is 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of CDI (1.2 equiv) and the proper carboxylic acid in anhydrous solvent under a N2 atmosphere, was stirred at 40-50 C for 3 h. The solution was then cooled at room temperature and 2-amino-5-nitrothiazole and in some cases 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was added. The mixture was heated at 60 C for 12-18 h, cooled at room temperature and water was added to precipitate the hybrid compounds. The solid was filtered and washed with acetone and water for give the corresponding hybrid compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-benzo[d]imidazole-6-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Soria-Arteche, Olivia; Hernandez-Campos, Alicia; Yepez-Mulia, Lilian; Trejo-Soto, Pedro Josue; Hernandez-Luis, Francisco; Gres-Molina, Jorge; Maldonado, Luis A.; Castillo, Rafael; Bioorganic and Medicinal Chemistry Letters; vol. 23; 24; (2013); p. 6838 – 6841;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem