530-62-1 Archives - Imidazoles-derivatives

Niemiec, Stephen M.’s team published research in Frontiers in Immunology in 2020 | CAS: 530-62-1

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Electric Literature of C7H6N4O

《Nanosilk increases the strength of diabetic skin and delivers CNP-miR146a to improve wound healing》 was written by Niemiec, Stephen M.; Louiselle, Amanda E.; Hilton, Sarah A.; Dewberry, Lindel C.; Zhang, Liping; Azeltine, Mark; Xu, Junwang; Singh, Sushant; Sakthivel, Tamil S.; Seal, Sudipta; Liechty, Kenneth W.; Zgheib, Carlos. Electric Literature of C7H6N4O And the article was included in Frontiers in Immunology in 2020. The article conveys some information:

Diabetes mellitus is a metabolic disorder associated with properties and an increased risk of chronic wounds due to sustained pro-inflammatory response. We have previously of radical scavenging cerium oxide nanoparticles (CNP) conjugated to the anti-inflammatory microRNA (miR)-146a, termed CNP-miR146a, improves diabetic wound healing by synergistically lowering oxidative stress and inflammation, and we sought to evaluate this treatment in a topical application. Silk fibroin is a biocompatible polymer that can be fabricated into nanostructures, termed nanosilk. Nanosilk is characterized by a high strength-to-d. ratio and an ability to exhibit strain hardening. We therefore hypothesized that nanosilk would strengthen the biomech. properties of diabetic skin and that nanosilk solution could effectively deliver CNP-miR146a to improve diabetic wound healing. The ability of nanosilk to deliver CNP-miR146a to murine diabetic wounds and improve healing was assessed by the rate of wound closure and inflammatory gene expression, as well as histol. anal. The effect of nanosilk on the properties of human diabetic skin was evaluated by testing the biomech. properties following topical application of a 7% nanosilk solution Diabetic murine wounds treated with topical nanosilk and CNP-miR146a healed by day 14.5 compared to day 16.8 in controls (p = 0.0321). Wounds treated with CNP-miR146a had higher collagen levels than controls (p = 0.0126) with higher pro-fibrotic gene expression of TGFβ-1 (p = 0.0092), Col3α1 (p = 0.0369), and Col1α2 (p = 0.0454). Treatment with CNP-miR146a lowered pro-inflammatory gene expression of lL-6 (p = 0.0488) and lL-8 (p = 0.0009). Treatment of human diabetic skin with 7% nanosilk solution resulted in significant improvement in maximum load and modulus (p < 0.05). Nanosilk solution is able to strengthen the biomech. properties of diabetic skin and can successfully deliver CNP-miR146a to improve diabetic wound healing through inhibition of pro-infl ammatory gene signaling and promotion of pro-fi brotic processes. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Electric Literature of C7H6N4O)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vu-Quang, Hieu’s team published research in Polymers (Basel, Switzerland) in 2019 | CAS: 530-62-1

Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Application In Synthesis of Di(1H-imidazol-1-yl)methanone

In 2019,Polymers (Basel, Switzerland) included an article by Vu-Quang, Hieu; Vinding, Mads Sloth; Nielsen, Thomas; Ullisch, Marcus Goerge; Nielsen, Niels Chr.; Nguyen, Dinh-Truong; Kjems, Jorgen. Application In Synthesis of Di(1H-imidazol-1-yl)methanone. The article was titled 《Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging》. The information in the text is summarized as follows:

Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clin. use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry anal., confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced neg. contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application In Synthesis of Di(1H-imidazol-1-yl)methanone)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Pengzhi’s team published research in Advanced Synthesis & Catalysis in 2022 | CAS: 530-62-1

In 2022,Wang, Pengzhi; Fitzpatrick, Keegan P.; Scheidt, Karl A. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Combined Photoredox and Carbene Catalysis for the Synthesis of γ-Aryloxy Ketones》.Product Details of 530-62-1 The author mentioned the following in the article:

N-heterocyclic carbenes (NHCs) have emerged as catalysts for the construction of C-C bonds in the synthesis of substituted ketones under single-electron processes. Despite these recent reports, there still remains a need to increase the utility and practicality of these reactions by exploring new radical coupling partners. Herein, authors report the synthesis of γ-aryloxyketones via combined NHC/photoredox catalysis. In this reaction, an α-aryloxymethyl radical is generated via oxidation of an aryloxymethyl potassium trifluoroborate salt, which is then added into styrene derivatives to provide a stabilized benzylic radical. Subsequent radical-radical coupling reaction with an azolium radical affords the γ-aryloxy ketone products.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Product Details of 530-62-1) was used in this study.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hokmabadi, Fahimeh’s team published research in Royal Society Open Science in 2022 | CAS: 530-62-1

In 2022,Hokmabadi, Fahimeh; Zadmard, Reza; Akbarzadeh, Ali; Tafakori, Vida; Jalali, Mohammad Reza; Ahmadian, Gholamreza published an article in Royal Society Open Science. The title of the article was 《Synthesis of a new chitosan-p-tert-butylcalix[4]arene polymer as adsorbent for toxic mercury ion》.COA of Formula: C7H6N4O The author mentioned the following in the article:

In this paper, we have synthesized a novel chitosan-p-tert-butylcalix[4]arene polymer (CCP) as a highly efficient adsorbent for mercury ion (Hg2+) removal from water. In fact, a lower rim diamine derivative of p-tert-butylcalix[4]arene has been cross-linked with chitosan chain by carbonyl diimidazole (CDI) as the linker. CDI forms a urea linkage between calix[4]arene diamine derivative and amine groups of the chitosan polymeric chain. The structure and properties of the new polymer were characterized by Fourier transform IR spectroscopy, X-ray diffraction and scanning electron microscope. Also, the adsorption capacity of CCP was studied towards Hg2+ in aqueous medium by inductively coupled plasma-optical emission spectrometry. Interestingly, the results showed a considerable adsorption capacity for CCP in comparison with chitosan. Therefore, CCP can be introduced as a promising adsorbent for the elimination of Hg2+ from wastewaters. Moreover, because of the conformity of adsorption kinetic with pseudo-second-order kinetic models, it can be concluded that chem. adsorption has an important role between functional groups on CCP polymer and Hg2+ ions. In addition, according to Freundlich isotherm, the CCP surface was heterogeneous with different functional groups. The experimental part of the paper was very detailed, including the reaction process of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1COA of Formula: C7H6N4O)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rout, Saroj K.’s team published research in Chemistry – A European Journal in 2022 | CAS: 530-62-1

Product Details of 530-62-1In 2022 ,《Prebiotically Plausible Autocatalytic Peptide Amyloids》 appeared in Chemistry – A European Journal. The author of the article were Rout, Saroj K.; Rhyner, David; Riek, Roland; Greenwald, Jason. The article conveys some information:

The prebiotic emergence of mols. capable both of self-replication and of storing information was a defining event at the dawn of life. Still, no plausible prebiotic self-replication of biol. relevant mols. has been demonstrated. Building upon the known templating nature of amyloids, we present two systems in which the products of a peptide-bond-forming reaction act as self-replicators to enhance the yield and stereoselectivity of their formation. This first report of an amino acid condensation that can undergo autocatalysis further supports the potential role of amyloids in prebiotic mol. evolution as an environment-responsive and information-coding system capable of self-replication. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Product Details of 530-62-1)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bardill, James R.’s team published research in Journal of Surgical Research in 2020 | CAS: 530-62-1

《Improved Coverage of Mouse Myelomeningocele With a Mussel Inspired Reverse Thermal Gel》 was written by Bardill, James R.; Park, Daewon; Marwan, Ahmed I.. Safety of Di(1H-imidazol-1-yl)methanone And the article was included in Journal of Surgical Research in 2020. The article conveys some information:

Myelomeningocele (MMC) is an open neural tube defect of the spinal column. Our laboratory previously introduced a reverse thermal gel (RTG) as the first in situ forming patch for in utero MMC application. To overcome the challenges of anchoring the RTG in the wet amniotic environment to improve MMC coverage, we modified the RTG to mimic the underwater adhesive properties of mussels. We have separated this study into three sep. hypotheses-based components:Based on mussel inspired chem., modification of the RTG with dopamine will increase the underwater adhesive properties to improve RTG anchoring ability in a wet environment. Methods: The dopamine-modified RTG (DRTG) was synthesized using carbonyldiimidazole chem. and characterized with proton NMR, Fourier transform IR spectroscopy, and UV-visible spectroscopy. Rheol. and underwater adhesive tests measured mech. properties. Results: DRTG synthesis was confirmed with proton NMR, Fourier transform IR spectroscopy, and UV-visible spectroscopy. Rheol. demonstrated increased elasticity. Underwater adhesion testing revealed DRTG has similar wet adhesive strength to Tisseel fibrin sealant.The DRTG will support in vitro skin cell growth and will be safe for injection in a mouse animal model. Methods: Biocompatibility testing included 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, DRTG-fibroblast and keratinocyte cultures, and s.c. injections to quantify macrophages stained with immunohistochem. Results: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and DRTG cell cultures revealed no cytotoxicity and demonstrated the growth of fibroblasts and keratinocytes. S.c. injections cause a macrophage response that decreases after 4 wk.In utero injection of novel DRTG into a mouse MMC model will be effective with improved patch coverage of the MMC defect. Methods: MMC coverage by DRTG was assessed using in utero mouse injections in the Grainy head-like 3 (Grhl3) mouse model. Results: In utero Grhl3 mouse injections demonstrate statistically significant (P = 0.012) improved MMC coverage of DRTG compared with previous RTG coverage with no significant macrophage response.The DRTG demonstrates increased elasticity, cellular scaffolding properties, and improved MMC coverage in the Grhl3 mouse model. Future studies will be translated to the preclin. ovine model to evaluate this novel gel. In addition to this study using Di(1H-imidazol-1-yl)methanone, there are many other studies that have used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Safety of Di(1H-imidazol-1-yl)methanone) was used in this study.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Qin, Bo’s team published research in Advanced Materials (Weinheim, Germany) in 2020 | CAS: 530-62-1

Quality Control of Di(1H-imidazol-1-yl)methanoneIn 2020 ,《Tough and Multi-Recyclable Cross-Linked Supramolecular Polyureas via Incorporating Noncovalent Bonds into Main-Chains》 appeared in Advanced Materials (Weinheim, Germany). The author of the article were Qin, Bo; Zhang, Shuai; Sun, Peng; Tang, Bohan; Yin, Zihe; Cao, Xiao; Chen, Quan; Xu, Jiang-Fei; Zhang, Xi. The article conveys some information:

Covalent thermosets generally exhibit robust mech. properties, while they are fragile and lack the ability to be reprocessed or recycled. Herein, a new strategy of incorporating noncovalent bonds into main-chains is developed to construct tough and multi-recyclable crosslinked supramol. polyureas (CSPU), which are prepared via the copolymerization of diisocyanate monomers, noncovalently bonded diamine monomers linked by quadruple hydrogen bonds, and covalent diamine/triamine monomers. The CSPU exhibit remarkable solvent resistance and outstanding mech. properties owing to the covalent crosslinking via triamine monomer. Through the incorporation of 9.7% and 14.6% quadruple hydrogen bonded diamine monomer, the transparent CSPU films are endowed with superior toughness of 74.17 and 124.17 MJ m-3, resp. Impressively, even after five generations of recycling processes, the mech. properties of reprocessed CSPU can recover more than 95% of their original properties, displaying excellent multiple recyclablity. As a result, the superior toughness, remarkable solvent resistance, high transparency, and excellent multiple recyclability are well-combined in the CSPU. It is highly anticipated that this line of research will provide a facile and general method to construct various crosslinked polymer materials with superior recyclability and mech. properties. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Quality Control of Di(1H-imidazol-1-yl)methanone)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xu, Q.’s team published research in Journal of Colloid and Interface Science in 2020 | CAS: 530-62-1

《Grafted nanocellulose and alkaline nanoparticles for the strengthening and deacidification of cellulosic artworks》 was published in Journal of Colloid and Interface Science in 2020. These research results belong to Xu, Q.; Poggi, G.; Resta, C.; Baglioni, M.; Baglioni, P.. Category: imidazoles-derivatives The article mentions the following:

Strongly degraded cellulosic artworks usually need deacidification and consolidation. Alk. nanoparticles are known to be effective in neutralizing the acidity, while cellulose nanocrystals have the potential to be used as compatible and effective strengthening agents. We have grafted cellulose nanocrystals with oleic acid using a 1’1-carbonyldiimidazole-mediated procedure, to increase their dispersibility in organic solvents, and synthesized Ca(OH)2 or CaCO3 nanoparticles via a solvothermal process. Grafted nanocellulose and alk. nanoparticles were used to prepare ethanol-based “”hybrids””. Prior to the application, the physico-chem. properties of nanocellulose dispersions and “”hybrids”” were studied by rheol. and small-angle X-ray scattering. Cellulose nanocrystals were effectively grafted and stably dispersed in ethanol. It was shown that the use of ethanol as a dispersing medium, and the addition of alk. nanoparticles act in a synergistic way, increasing the interactions between grafted cellulose nanocrystals, leading to the formation of clusters. These dispersions are thixotropic, a behavior particularly appealing to conservation purposes, since they can be applied in the liquid state, or, when a more confined application is required, they can be applied in a gel-like state. As a result of the application, an improvement in the mech. properties of paper and an increase of pH were obtained. In the experimental materials used by the author, we found Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Category: imidazoles-derivatives)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zou, Bin’s team published research in Applied Biochemistry and Biotechnology in 2020 | CAS: 530-62-1

《Metal-Organic Frameworks Conjugated Lipase with Enhanced Bio-catalytic Activity and Stability》 was written by Zou, Bin; Zhang, Liming; Xia, Jiaojiao; Wang, Pengyun; Yan, Yan; Wang, Xinyi; Adesanya, Idowu Onyinye. Related Products of 530-62-1 And the article was included in Applied Biochemistry and Biotechnology in 2020. The article conveys some information:

Covalent immobilization of lipase onto a solid carrier is an effective way to enhance stability. Immobilization inhibits the activity of lipase due to decreased flexibility of enzyme structure via the covalent bond. In this study, monomer of the metal-organic frameworks (MOFs) material ZIF-8 (2-Me imidazole-4-carboxylic acid) was innovatively used as a chem. modifier of Candida nrugosa lipase (CRL). The CD spectra results show that the CRL mol. was altered by chem. modification and thus its catalytic activity was 1.3 times higher than that of the free CRL. The modified CRL mol. was further immobilized in the “”skeleton”” of ZIF-8 through the monomer while in situ forming the cell skeleton of the MOFs, which prevent the active center from being destroyed. The results show that conjugation of chem. modification and immobilized enzymes ensure that there was no obvious reduction in the activity of CRL after immobilization and the stability of CRL was improved. Especially, the organic solvent stability of the modified immobilization CRL in isopropanol was significantly improved and retained more than 148% of its activity.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Related Products of 530-62-1) was used in this study.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hermanns, Volker’s team published research in Chemistry – A European Journal in 2021 | CAS: 530-62-1

Hermanns, Volker; Scheurer, Maximilian; Kersten, Nils Frederik; Abdellaoui, Chahinez; Wachtveitl, Josef; Dreuw, Andreas; Heckel, Alexander published their research in Chemistry – A European Journal in 2021. The article was titled 《Rethinking Uncaging: A New Antiaromatic Photocage Driven by a Gain of Resonance Energy》.Recommanded Product: 530-62-1 The article contains the following contents:

Photoactivatable compounds for example photoswitches or photolabile protecting groups (PPGs, photocages) for spatiotemporal light control, play a crucial role in different areas of research. For each application, parameters such as the absorption spectrum, solubility in the resp. media and/or photochem. quantum yields for several competing processes need to be optimized. The design of new photochem. tools therefore remains an important task. In this study, we exploited the concept of excited-state-aromaticity, first described by N. Colin Baird in 1971, to investigate a new class of photocages, based on cyclic, ground-state-antiarom. systems. Several thio- and nitrogen-functionalized compounds were synthesized, photochem. characterized and further optimized, supported by quantum chem. calculations After choosing the optimal scaffold, which shows an excellent uncaging quantum yield of 28 %, we achieved a bathochromic shift of over 100 nm, resulting in a robust, well accessible, visible light absorbing, compact new photocage with a clean photoreaction and a high quantum product (ε·Φ) of 893 M-1 cm-1 at 405 nm. The results came from multiple reactions, including the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Recommanded Product: 530-62-1)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem