Category: 52548-84-2

Freter, K. published the artcile4-(Indolyl-3)-1-(benzimidazolonylalkyl)piperidines, a novel group of potential antiallergy compounds, Quality Control of 52548-84-2, the main research area is benzimidazolone indolylpyridylalkyl antihistamine.

Antiallergic I (R1 = H, Me, Me2CH, R2 = H, Me, R3 = H, Me, isopropenyl, R5 = H, n = 2-6) were prepared in 34-92% yields by treating indole II with the corresponding N-(ω-chloroalkyl)benzimidazolinones III. I (R1 = R2 = R3 = R5 = H, n = 3) had an in vitro antihistaminic activity IC50 of 0.018 μg/mL compared to 0.030 μg/mL for oxatomide.

Arzneimittel-Forschung published new progress about Allergy. 52548-84-2 belongs to class imidazoles-derivatives, name is 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, and the molecular formula is C9H9ClN2O, Quality Control of 52548-84-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Poplawska, Magdalena published the artcileDetermination of flibanserin and tadalafil in supplements for women sexual desire enhancement using high-performance liquid chromatography with tandem mass spectrometer, diode array detector and charged aerosol detector, Recommanded Product: 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, the main research area is flibanserin tadalafil determination counterfeit herbal supplement HPLC mass spectrometry; Adulteration; Charged aerosol detector; Counterfeit herbal supplement; Flibanserin; Unified calibration.

The new compound – flibanserin – begun to appear as a synthetic adulterant in counterfeit herbal supplements used to stimulate women sexual drive. It was detected in 2 samples submitted to the Polish National Medicines Institute for anal. The second sample contained also tadalafil. This study presents the LC method development which enables the determination of flibanserin and tadalafil. It employs 3 different detectors charged aerosol detector (CAD), diode array detector (DAD) and mass spectrometer (MS). The conditions of the elaborated method were optimized to obtain the highest sensitivity and the best resolution, especially the separation of icariin – the natural compound observed often in supplements for sexual disorders. The validation of the method proved good linearity, good accuracy and precision of the measurements recorded by all 3 detectors. Addnl., for CAD data, an alternative calculation method using a unified calibration function was presented and evaluated. It seems that this is the way to overcome the problem of non-availability of the reference standard of a target compound Flibanserin content was quantified using the data of other reference standard (tadalafil). The inaccuracy of proposed indirect determination was found to be ±3%. A statistical evaluation proved that the results obtained with all detection modes and the results calculated using a unified calibration were not significantly different (p > 0.05).

Journal of Pharmaceutical and Biomedical Analysis published new progress about Counterfeiting. 52548-84-2 belongs to class imidazoles-derivatives, name is 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, and the molecular formula is C9H9ClN2O, Recommanded Product: 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boegesoe, Klaus P. published the artcileAntihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity, Recommanded Product: 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, the main research area is piperazinophenylindan preparation antihypertensive structure activity; irindalone preparation antihypertensive; hydroxytryptamine antagonist piperazinophenylindan.

A series of trans-1-piperazino-3-phenylindans, e.g., I (R = H, F; R1 = H, 2-F, 4-F, 4-Cl, 4-OH, 4-OMe; n,m = 2,3; X = NH, O, CH2, NH, NMe, NEt, NCHMe2; X1 = O, S) were synthesized with the goal of replacing their established neuroleptic profile with that of peripheral 5-hydroxytryptamine (5-HT2) antagonism. Compounds with an unsubstituted for F-substituted in the 6-position in the indan ring, and which had a five- or six-membered heterocyclic ring attached by an ethylene chain to the piperazine ring, satisfied this objective. Some of the compounds had potent antihypertensive activity in conscious spontaneously hypertensive rats. In pithed rats they antagonized the pressor effect induced by 5-HT in doses 100-1000 times lower than doses needed to antagonize the pressor effect of phenylephrine. The effect was stereoselective and associated with enantiomers with 1R,3S absolute configuration. 1S,3R Enantiomers inhibited the uptake of dopamine and norepinephrine in vitro. The compound with the best antihypertensive activity was irindalone. Its pharmacol. profile resembled that of the standard compound ketanserin. There was a close structural correspondence between ketanserin and irindalone in a conformation that was identified as a D-2 receptor-relevant configuration of its neuroleptic parent tefludazine. This suggests that the dopaminergic (D-2) and the serotoninergic (5-HT2) pharmacophores are structurally closely related.

Journal of Medicinal Chemistry published new progress about Antihypertensives. 52548-84-2 belongs to class imidazoles-derivatives, name is 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, and the molecular formula is C9H9ClN2O, Recommanded Product: 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diez-Barra, Enrique published the artcileN,N’-linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) and the x-ray crystal structure of a benzimidazolin-2-one trimer, SDS of cas: 52548-84-2, the main research area is benzimidazolone oligomer mol crystal structure.

Seven dimers, three trimers, a cyclic tetramer, and an open chain benzimidazolin-2-one heptamer have been prepared and characterized by 1H, 13C NMR and by MS. The crystal and mol. structure of the trimer, 1,3-bis[2-(2-oxobenzimidazol-1-yl)ethyl]-2-oxobenzimidazole, has been solved by x-ray anal. The mols. are hydrogen bonded to four others in a continuous two-dimensional network by N-H···O=C and C-H···O=C interactions in which all N-H donors and O=C acceptors are involved.

Tetrahedron published new progress about Crystal structure. 52548-84-2 belongs to class imidazoles-derivatives, name is 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, and the molecular formula is C9H9ClN2O, SDS of cas: 52548-84-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem