Category: 52538-09-7

Synthesis and proton NMR spectra of 2-heteroaryl-substituted imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines was written by Yutilov, Yu. M.;Shcherbina, L. I.;Efremenko, A. F.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1989.HPLC of Formula: 52538-09-7 The following contents are mentioned in the article:

The title compounds were prepared by oxidation of mixtures of 2,3- or 3,4-pyridinediamines with heterocycles containing an active Me group in the presence of S. Other methods involved cyclization of pyridinediamines with picoline N-oxides and 2-pyridinethiocarboxanilides and the intramol. oxidative cyclization of N⁴-(2-pyridylmethyl)-3,4-pyridinediamine. In most cases, the yield was â‰?0%. The NMR spectra of 2-pyridylimidazopyridines were examined This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7HPLC of Formula: 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2-Aldehydes of imidazo[4,5-b]- and imidazo[4,5-c]pyridines was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine The following contents are mentioned in the article:

Imidazopyridinecarboxaldehydes (I, R = Me, PhCH2, Ph, R1 = CHO), II (R1 = CHO), III (R1 = CHO), and IV (R = PhCH2, Ph, R1 = CHO) were obtained in 50-84% yields by oxidation of the corresponding 2-methyl derivative with SeO2 in dioxane at 70-80°. Condensation of the aldehydes with CH2(CO2H)2 gave 43-60% acrylic acid derivatives I (R = Me, R1 = CH:CHCO2H). II (R1 = CH:CHCO2H), and IV (R = Ph, R1 = CH:CHCO2H). The cyano derivatives I (R = Me, PhCH2R1 = CN), II (R1 = CN), and IV (R = PhCH2, Ph, R1 = CN) were obtained in 65-93% by boiling the corresponding aldoximes with Ac2O 7 hr. Amides I (R = Me, PhCH2, R1 = CONM2), II (R1 = CONH2), and IV (R = Ph, R1 = CONH2) were obtained in 60-82% yields by oxidation of the corresponding nitriles with concentrated H2SO4. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Determination of the structure of 2-methylimidazo[4,5-c]pyridine glycosides was written by Miroshnichenko, N. S.;Kovalenko, A. S.;Stetsenko, A. V.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1974.Related Products of 52538-09-7 The following contents are mentioned in the article:

Imidazopyridine glycosides (I; R = tri-O-acetyl-β-D-ribopyranosyl, β-D-ribopyranosyl, tri-O-acetyl-β-D-xylopyranosyl β-D-xylopyranosyl, tetra-O-acetyl-β-D-galactopyranosyl, β-D-galactopyranosyl) were prepared by known methods in 49-86%yields and their structures confirmed by NMR. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Related Products of 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Willgerodt reaction in a series of imidazopyridine derivatives was written by Yutilov, Yu. M.;Shcherbina, L. I.. And the article was included in Zhurnal Organicheskoi Khimii in 1996.Related Products of 52538-09-7 The following contents are mentioned in the article:

The Willgerodt reaction of 2-methylimidazopyridines with aniline and sulfur gave imidazopyridinecarbothioanilides such as I (R = Me, benzyl, Ph, H; R¹ = H, Br). Intramol. versions of this reaction gave tetracyclic products, e.g., II. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Related Products of 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New method for synthesis of 2-hetaryl-substituted imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Reference of 52538-09-7 The following contents are mentioned in the article:

Imidazopyridines I [X = Y = CH, Z = N, R = 6-methyl-2-pyridyl (II), 2-quinolyl (III), imidazo [4,5-c] pyridin-2-yl (IV), R1 = H; X = N, Y = Z = CH, R = II, 2-benzothiazolyl, 2-benzimidazoyl, III, 1-methylimidazo[4,5-c]pyridin-2-yl, R1 = Me; X = Z = CH, Y = N, R = IV, R1 = Me] were obtained in 83-98% yields by treatment of the corresponding diaminopyridine V with MeR 3-8h at 165-200°. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Reference of 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Reference of 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A novel preparation of thiazolo[5,4-c]pyridines and the synthesis of some imidazo[4,5-c]pyridines and oxazolo[4,5-c]pyridines was written by Katner, Allen S.;Brown, Raymond F.. And the article was included in Journal of Heterocyclic Chemistry in 1990.SDS of cas: 52538-09-7 The following contents are mentioned in the article:

Diethoxymethyl acetate was used to cyclize o-disubstituted aminopyridines to oxazolo [4,5-c]pyridines and imidazo[4,5-c]pyridines. All the possible imidazole-methylated imidazo[4,5-c]pyridines were prepared A novel synthesis of 2-substituted thiazolo[5,4-c]pyridines and 4-amino-3-pyridinethiol was discovered. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7SDS of cas: 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazoles. IX. A new preparation of N-alkylated imidazole compounds was written by Weidenhagen, Rudulf;Train, Gert;Wegner, Hans;Nordstrom, Ludwig. And the article was included in Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen in 1942.Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine The following contents are mentioned in the article:

A solution of 2 g. Cu(OAc)₂, 2 cc. 40% HCHO and 30 cc. H₂O at 0° is treated with 1 g. ο-H₂NC₆H₄NHMe.2HCl in 15 cc. 50% alc. at 0°; the CuCl salt precipitates immediately and the reaction is completed by heating 10 min. at 75°; decomposition with H₂S in dilute HCl gives the HCl salt, which is liberated by K₂CO₃; the yield of 1-methylbenzimidazole (I) is 67%; AcH gives 83% of the 2-Me derivative of I; EtCHO yields the 2-Et derivative, very hygroscopic, m. 61.5-2.5° (containing 0.79 mol. H₂O), m. 54.5-5.5° (anhydrous); picrate, m. 235-6°; iso-PrCHO gives 84% of the 2-iso-Pr derivative, b_0.3 116-18° (picrate, yellow, m. 225-6°); BzH gives 87.5% of the 2-Ph derivative; p-MeOC₆H₄CHO yields 77.5% of the 2-(p-methoxyphenyl) derivative, m. 118°; 2-(p-nitrophenyl) derivative, yellow, m. 213-14°, 88%; 2-(2-furyl) derivative, with 0.5 mol. H₂O, m. 78° (anhydrous, m. 56°), 85%. ο-O₂NC₆H₄NHEt with SnCl₂ in HCl gives 69% of N-ethyl-ο-phenylenediamine (II), m. 185-7° (decomposition). II, HCHO and Cu(OAc)₂ give 71% of 1-ethylbenzimidazole (III); AcH yields 90% of the 2-Me derivative of III, b_0.3 110-12° (picrate, m. 236-7°); EtCHO gives 74% of the 2-Et derivative of III, b_0.2 106.5-7.5° (HCl salt, m. 168.5-9.5°; picrate, m. 207°); BzH yields 82% of the 2-Ph derivative of III; 2-(p-methoxyphenyl) derivative, m. 106-6.5°, 90%; 2-(m-nitrophenyl) derivative, m. 117.5-18°, 46%. ο-ClC₆H₄NO₂ and PrNH₂ in EtOH, heated 7 hrs., give 97% of N-propyl-ο-nitroaniline, red oil; reduction yields 57% of N-propyl-ο-phenylenediamine-2-HCl (IV), m. 172-3° (decomposition). IV, HCHO and Cu(OAc)₂ give 62% of 1-propylbenzimidazole (V), analyzed as the picrate, m. 180-1°; IV and AcH give 92% of the 2-Me derivative of V, hygroscopic oil, b_0.2 111-12° (picrate, m. 218-19°); 2-Et derivative, 85%; picrate, m. 212-12.5°; 2-(p-methoxyphenyl) derivative, m. 67.5-8°. 3-Amino-4-(methylamino)pyridine (VI), m. 169°, results in 95% yield on reduction of the 3-NO₂ compound with Fe in AcOH (picrate, m. 184°; HCl salt, m. 221°). VI (1.8 g.), 1 cc. AcH and 6 g. Cu(OAc)₂ in 50 cc. 50% EtOH, heated 3 hrs. at 150°, give 50% of 1′,2′-dimethylimidazolo-4′,5′,3,4-pyridine (VII), m. 174° (picrate, m. 204-5°); EtCHO gives 48% of the 2′-Et analog of VII, with 1.5 mols. H₂O, m. 76°; 2′-Pr analog, with 1.5 mols. H₂O, m. 64°, 59%; 2′-hexyl analog, a hygroscopic oil, analyzed as the dioxalate, m. 140°, 47%; 2′-Ph analog, m. 149°, 49% (hydrated, m. 79-80°); 2′-(2-furyl) analog, m. 173°, 57%. 3-Amino-4-(ethylamino)pyridine, AcH and Cu(OAc)₂ in EtOH, heated 4.5 hrs. at 150°, give 1′-ethyl-2′-methylimidazolo-4′,5′,3,4-pyridine, m. 84°; with 1 mol. of H₂O, m. 40°; picrate, m. 191°; 2′-Et analog, hygroscopic oil; with 2 mols. H₂O, m. 52°, 54%; 2′-Pr analog, very hygroscopic oil, 39%; with 2 mols. H₂O, m. 68°; 2′-(p-methoxyphenyl) analog, m. 142°, 71%; 2′-(2-furyl) analog, pale yellow, m. 125°, 68%. 3-Nitro-4-(propylamino)pyridine, in nearly theoretical yield by boiling 3-nitro-4-methoxypyridine with PrNH₂ in EtOH; 3-NH₂ derivative, with 1 mol. H₂O, m. 93°, 78%. 1′-Propyl-2′-methylimidazolo-4′,5′,3,4-pyridine, analyzed as the picrate, yellow, m. 156.5-7.5°; 1′-Bu analog, with 2 mols H₂O, m. 47°, 58%. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem