Category: 50995-95-4

50995-95-4,Some common heterocyclic compound, 50995-95-4, name is 2-Propylimidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

11. 4-(2-Propylimidazol-1-yl)benzyl alcohol Prepared from 2-propylimidazol and ethyl 4-fluorobenzoate. MW: 216.29 1 H NMR (CDCl3) delta: 7.60-7.80(m, 6H), 4.80(s, 2H), 2.70-2.45 (m, 2H), 2.00-1.50(m, 3H), 1.00-0.70(m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Propylimidazole, its application will become more common.

Reference:
Patent; Pfizer Inc.; US5753682; (1998); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50995-95-4 name is 2-Propylimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 50995-95-4

EXAMPLE 12 1-(6-Methylergolin-8beta-ylmethyl)-2-propylimidazole 0.68 g of 50% sodium hydride in an oil was added in small portions to a mixture of 2.1 g of 2-propylimidazole and 50 ml of dimethylformamide, and the resulting mixture was stirred for 30 minutes. 2.0 g of 6-methylergolin-8beta-ylmethyl tosylate was added to the mixture which was then heated on a water bath for 2.5 hours. The solvent was distilled off under reduced pressure, and the residue was purified by alumina column chromatography (eluted with ethyl acetate_benzene=1:2, and then with ethyl acetate). The resulting product was recrystallized from acetone-hexane to obtain 0.8 g of the titled compound as colorless needles having a melting point of 223-227 C. (with decomposition). NMR (CDCl3) delta: 1.01 (3H, t, J=6.9 Hz), 1.17 (1H, q, J=12.0 Hz), 1.60-3.12 (11H, m), 2.43 (3H, s), 3.37 (1H, dd, J=14.4, 3.8 Hz), 3.78 (2H, d, J=6.8 Hz), 6.71-7.25 (6H, m), 7.94 (1H, br).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Propylimidazole, and friends who are interested can also refer to it.

Reference:
Patent; Maruko Seiyaku Co., Ltd.; US4713457; (1987); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem