Category: 50995-95-4

Electric Literature of 50995-95-4,Some common heterocyclic compound, 50995-95-4, name is 2-Propylimidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 2-propylimidazole (0.22 g, 2.04 mmol) to a 150 mL round bottom flask.After stirring potassium carbonate as a base (0.30 g, 2.20 mmol) and acetonitrile as a solvent at 50 C for 40 minutes,After cooling to room temperature, intermediate V (0.43 g, 1.70 mmol) was added and the mixture was warmed to 75 C and the mixture was traced to the end of the reaction.After further concentration, extraction, column chromatography separation, drying and the like, the intermediate VII-4 (0.45 g) is obtained, the yield is 72.6%;a white solid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Propylimidazole, its application will become more common.

Reference:
Patent; Southwest University; Zhou Chenghe; Man Nabaonei·lamohan·laao·yadafu; Wang Juan; (39 pag.)CN110305064; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 50995-95-4,Some common heterocyclic compound, 50995-95-4, name is 2-Propylimidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A vessel with a magnetic stirrer bar was charged with imidazole derivative (0.5 mmol), CuI (10 mg, 0.05 mmol), Cs2CO3 (0.33 g, 1 mmol), PPh3 (26 mg, 0.1 mmol) and tetrabutylammonium bromide (TBAB) (0.2 g, 0.6 mmol) under a nitrogen atmosphere. The reaction vessel was evacuated and backfilled with nitrogen three times. In a separate flask, a solution of dry dioxane (2 mL) containing the 1,1-dihalo-1-alkenes (1 mmol) was evacuated and back-filled with nitrogen gas three times. The dioxane solution was then added to the reaction flask via a syringe and the reaction mixture heated to 100 C for 30 hours. The reaction mixture was cooled to room temperature, quenched with 5 mL of a saturated NH4Cl solution, and extracted with ethyl acetate (3 x 10 mL). The combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash column chromatography with ethyl acetate (EA) and petroleum ether (Pet) as the eluent to afford the corresponding products:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Propylimidazole, its application will become more common.

Reference:
Article; Wang, Man-Gang; Yu, Hua; Wu, Jun; Shang, Zhi-Cai; Journal of Chemical Research; vol. 37; 9; (2013); p. 570 – 573;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 50995-95-4, The chemical industry reduces the impact on the environment during synthesis 50995-95-4, name is 2-Propylimidazole, I believe this compound will play a more active role in future production and life.

Preparation of 2-chloro-6-(2-propylimidazol- 1 -vDpurine. Method 1: 2,6-Dichloropurine (0.38 g, 2 mmol) and 2-propylimidazole (1.32 g, 12 mmol) were dissolved in freshly distilled DMF (10 mL), and the mixture was stirred at 65 C for 20 h. Volatiles were evaporated in vacuo, and the residue was dissolved EPO in 0.1 N NaOH/H2O//CH2Cl2 (100 mL/50 mL). The organic phase was extracted with 0.1 N NaOHZH2O (3 x 50 mL). The combined aqueous phase was washed with CH2Cl2 (2 x 50 mL) and neutralized with CO2. The precipitated solid was filtered and washed (H2O) to give 2-chloro-6-(2-propylimidazol-l-yl)purine (0.38 g, 72%): mp 224.5-225 C; UV (MeOH) max 215, 288 nm (epsilon 25 800, 16 700), min 332, 241 nm (epsilon 2500, 4500); 1H NMR (500 MHz, DMSO-J6) delta 14.04 (br s, IH), 8.69 (s, IH), 8.43 (s, IH), 7.06 (s, IH,), 3.12 (t, J= 7.5 Hz, 2H), 1.72 (sext, J= 7.3 Hz, 2H), 0.95 (t, J= 7.3 Hz, 3H); 13C NMR ( 125 MHz, DMSO-^6) delta 157.3, 151.7, 150.2, 147.2, 146.6, 128.9, 122.5, 121.1, 32.4, 21.5, 14.5; HRMS m/z 262.0723 (M+ [Ci1H11ClN6] = 262.0734). Anal. Calcd for CnHnClN6: C, 50.29; H, 4.22; N, 31.99. Found: C, 50.02; H, 4.28; N, 31.64.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Propylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRIGHAM YOUNG UNIVERSITY, TRANSFER TECHNOLOGY OFFICE; WO2006/138396; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 50995-95-4, name is 2-Propylimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50995-95-4, category: imidazoles-derivatives

Taking 2 – propyl imidazole 11.0g (0.1 muM), KOH 8.4g (0.15 muM), K2CO313 . 8g (0.1 muM) and tetrabutyl ammonium bromide 1.6g (0.005 muM) dissolved in 75 ml dichloromethane in, room temperature stirring 0.5h after, slow instillment bromine ethyl acetate 0.1 muM (11.2 ml), dropwise, 39 C reflow 9h, filtering, saturated salt water washed filtrate three times, dried with anhydrous sodium sulfate, 25 C distilling the organic phase to liquid droplet not to trickle out, obtaining oil object, to obtain the compound IV intermediate 1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Propylimidazole, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Atomic Medical Institute; Qiu Ling; Lin Jianguo; Lv Gaochao; Li Ke; Peng Ying; Luo Shineng; Wang Shanshan; Zhao Xueyu; (27 pag.)CN106749406; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 50995-95-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50995-95-4 as follows.

[0675] A solution of 2-propylimidazole (76 mg, 0.69 mmol) in 1 mL DME was added to a mixture NaH (32 mg, 0.81 mol, 60% dispersion in mineral oil) at 0 C under argon. After 20 min, a solution of the product of Example 157 Step 3 (250 mg, 0.62 mol) in 2 mL DME was added at 0 C. The reaction was warmed to 25 C. After 1.5 h, the reaction was filtered through a pad of Celite (1″), and washed with EtOAc (20 mL). The filtrate was concentrated to give a pale brown oil in 0.21 g (80%).

According to the analysis of related databases, 50995-95-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/87686; (2004); A2;; ; Patent; PHARMACIA CORPORATION; WO2004/87687; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50995-95-4 as follows. name: 2-Propylimidazole

EXAMPLE 19 8-(2-n-Propyl-1H-imidazol-1-yl)-7-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxaline-1,4(2H,5H)-dione, hydrochloride The title compound was prepared from 4-amino-2-fluoro-5-nitrobenzotrifluoride and 2-n-propylimidazole by a method analogous to the method described in example 10. M.p.>300 C. 1 H-NMR (DMSO-d6): delta0.86 (t, 3H), 1.55-1.79 (m, 2H), 2.65 (t, 2H), 7.83 (d, 1H), 7.87 (s, 1H), 7.91 (br.s, 1H), 8.82 (s, 1H), 12.44 (s, 1H), 13.30 (s, 1H).

According to the analysis of related databases, 50995-95-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Novo Nordisk A/S; US5532236; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50995-95-4, name is 2-Propylimidazole, A new synthetic method of this compound is introduced below., COA of Formula: C6H10N2

Copper (I) Iodide (0.038g) and D-histidine (0.062g) in DMSO (15ml) was stirred under an atmosphere of argon at 11O0C for 30 minutes when 3-(4-bromophenyl)-1 ,4- diazaspiro[4.5]dec-3-en-2-one (D6) (0.614g), 2-propylimidazole (264mg) and potassium carbonate (0.553g) was added and heating was continued at 11 O0C for 5 days when the mixture was poured into a mixture of sodium bicarbonate solution and ethyl acetate. The mixture was stirred for 2 hours, filtered and the filtrate was separated. The ethyl acetate layer was dried over sodium sulphate, evaporated and the residue was chromatographed on a silica column eluted with 0-5% 2M methanolic ammonia/DCM to give the title compound (0.2g).1H NMR (CDCI3) delta: 1.4 (3H, t), 1.5 – 1.85 (obs, m), 1.9 – 2.1 (4H, m) 2.7 (2H, t), 7.00 (1 H, m), 7.09 (1 H, m), 7.4 (2H, m), 7.82 (1 H, br), 8.55 (2H, m). Mass Spectrum (LC/MS): Found 337 (MH+). Ret. time 1.87 min.

The synthetic route of 50995-95-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/34061; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 50995-95-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50995-95-4, name is 2-Propylimidazole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 16 8-(2-n-Propyl-1H-imidazol-1-yl)-7-nitro[1,2,4]triazolo[4,3-a]quinoxaline-1,4(2H,5H)-dione The title compound was prepared from 8-fluoro-7-nitro[1,2,4]triazolo[4,3-a]quinoxaline-1,4(2H,5H)-dione and 2-n-propylimidazole by a method analogous to the method described in example 11. M.p. 260C decomp. 1-NMR (DMSO-d6: delta 13.3 (1H, s), 12.3 (1H, s), 8.50 (1H, s), 8.05 (1H, s), 7.25 (1H, d), 7.00 (1H, d), 2.35 (2H, t), 1.55 (2H, q), 0.85 (3H, t).

The chemical industry reduces the impact on the environment during synthesis 2-Propylimidazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVO NORDISK A/S; EP698024; (1997); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50995-95-4, name is 2-Propylimidazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Propylimidazole

A stirred mixture of [5- (3-FLUORO-4-METHANESULFONYL-PHENYL)-4-METHYL-THIAZOL-2-YL]- (LH-PYRAZOL-3-YL)-AMINE hydrobromide salt (68d) (1.0 g, 2.3 mmol), Caesium carbonate (1.50 g, 4.6 mmol) and 2-propylamidazole (0. 508 g, 4.6 mmol) in dry DMSO (10 ml) is heated at 140 C for 6 hours. After cooling to room temperature the mixture is diluted with ethyl acetate (50 ml) and washed with water (100 ml). The organic extract is separated and the crude product is absorbed on silica. Purification by chromatography on silica, eluting with ethyl acetate-ethanol (1: 1) affords the titled compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50995-95-4.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/78754; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 50995-95-4,Some common heterocyclic compound, 50995-95-4, name is 2-Propylimidazole, molecular formula is C6H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1(a) Ethyl-2-(2-propylimidazol-1-yl)propanoate 2-Propylimidazole (5.5 g), ethyl 2-bromopropionate (9.95 g) and potassium carbonate (12.4 g) were stirred in refluxing acetonitrile (100 ml) for 72 hours. The suspension was allowed to cool, filtered and the solvent removed under reduced pressure, yielding the title compound as an off-white foam, 9.2 g [88%].

The synthetic route of 50995-95-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4853392; (1989); A;; ; Patent; Pfizer Limited; EP299727; (1991); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem