Category: 5036-48-6

Wang, Sisi; Du, Liang; Donmez, Selin; Xin, Yan; Mattoussi, Hedi published an article in 2021, the title of the article was Polysalt ligands achieve higher quantum yield and improved colloidal stability for CsPbBr3 quantum dots.Reference of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Colloidal lead halide perovskite quantum dots (PQDs) are relatively new semiconductor nanocrystals with great potential for use in optoelectronic applications. They also present a set of new scientifically challenging fundamental problems to investigate and understand. One of them is to address the rather poor colloidal and structural stability of these materials under solution phase processing and/or transfer between solvents. In this contribution, we detail the synthesis of a new family of multi-coordinating, bromide-based polysalt ligands and test their ability to stabilize CsPbBr3 nanocrystals in polar solutions The ligands present multiple salt groups involving quaternary cations, namely ammonium and imidazolium as anchors for coordination onto PQD surfaces, along with several alkyl chains with varying chain length to promote solubilization in various conditions. The ligands provide a few key benefits including the ability to repair damaged surface sites, allow rapid ligand exchange and phase transfer, and preserve the crystalline structure and morphol. of the nanocrystals. The polysalt-coated PQDs exhibit near unity PLQY and significantly enhanced colloidal stability in ethanol and methanol. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Reference of N-(3-Aminopropyl)-imidazole

The Article related to cesium lead bromide quantum dot polysalt ligand colloidal stability, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 23, 2021, Fallica, Antonino N.; Sorrenti, Valeria; D鈥睞mico, Agata G.; Salerno, Loredana; Romeo, Giuseppe; Intagliata, Sebastiano; Consoli, Valeria; Floresta, Giuseppe; Rescifina, Antonio; D鈥睞gata, Velia; Vanella, Luca; Pittala, Valeria published an article.Product Details of 5036-48-6 The title of the article was Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity. And the article contained the following:

Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, mol. modeling, and biol. evaluation of novel HO-1 inhibitors. Specifically, an amide linker in the central spacer and an imidazole were fixed, and the hydrophobic moiety required by the pharmacophore was largely modified. In many tumors, overexpression of HO-1 correlates with poor prognosis and chemoresistance, suggesting the inhibition of HO-1 as a possible antitumor strategy. Accordingly, compounds 7i and 7l-p emerged for their potency against HO-1 and were investigated for their anticancer activity against prostate (DU145), lung (A549), and glioblastoma (U87MG, A172) cancer cells. The selected compounds showed the best activity toward U87MG cells. Compound 7l was further investigated for its in-cell enzymic HO-1 activity, expression levels, and effects on cell invasion and vascular endothelial growth factor (VEGF) extracellular release. The obtained data suggest that 7l can reduce cell invasivity acting through modulation of HO-1 expression. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to acetamide derivative heme oxygenase inhibitor preparation cancer, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 14, 2020, Chatterjee, Kajari; Pathak, Anil D.; Sahu, Kisor Kumar; Singh, Akhilesh Kumar published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was New Thiourea-Based Ionic Liquid as an Electrolyte Additive to Improve Cell Safety and Enhance Electrochemical Performance in Lithium-Ion Batteries. And the article contained the following:

Our society is critically dependent on lithium-ion batteries (LIBs) as a power source for portable electronic gadgets. One of the major problems with these batteries is the degradation of the materials inside them. In addition to the reduced cell life, building-up of these degraded products inside the cells is very detrimental to the safe operation. Herein, we report the synthesis and characterization of a novel thiourea-based room temperature ionic liquid (IL), 3-heptyl-1-(3-(3-heptyl-3-phenylthioureido)propyl)-1H-imidazole-3-ium hexafluorophosphate. Its electrochem. and thermal properties including transport phenomena have been studied. It is proposed to be used as a nominal additive to com. used electrolytes, ethylene carbonate and di-Me carbonate mixtures The comparative performance characteristics of the LIBs in the presence and the absence of this IL additive have been demonstrated with a traditional lithium nickel cobalt manganese oxide cathode (NMC111), a graphite anode, and an ethylene carbonate and di-Me carbonate (1:1, volume/volume) electrolyte. It is further demonstrated that use of this electrolyte additive in batteries helps to address some of the major concerns of the conventional electrolytes such as safety issues and cycling performance as well as coulombic efficiency with enhanced discharge capacities. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to lithium ion battery electrolyte ionic liquid additive safety, Placeholder for records without volume info and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gutierrez-Pena, Cristian L.; Poyatos, Macarena; Peris, Eduardo published an article in 2022, the title of the article was A redox-switchable catalyst with an unplugged redox tag.Application In Synthesis of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Two bis-(propyl-imidazolium)-naphthalenediimide (NDI) salts were prepared and used as N-heterocyclic carbene (NHC) precursors for the preparation of dimetallic complexes of rhodium and iridium. IR spectroelectrochem. studies indicate that the metals are sensitive to changes in the electronic state of the NDI moiety. The catalytic behavior of the rhodium and iridium complexes was tested in the cycloisomerization of alkynoic acids, where the complexes showed effective redox-switching properties. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to ndi salt nhc redox switchable cycloisomerization catalyst, Placeholder for records without volume info and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 9, 2021, Nosratabad, Neda Arabzadeh; Jin, Zhicheng; Du, Liang; Thakur, Mannat; Mattoussi, Hedi published an article.Synthetic Route of 5036-48-6 The title of the article was N-Heterocyclic Carbene-Stabilized Gold Nanoparticles: Mono- Versus Multidentate Ligands. And the article contained the following:

Over the past decade, N-heterocyclic carbenes (NHCs) have attracted remarkable attention as metal-coordinating ligands because of their ability to strongly interact with transition metal complexes and surfaces. We investigate the coordination interaction between colloidal gold nanoparticles (AuNPs) and three sets of hydrophilic NHC-based ligands: an amine-modified small mol., a monomeric NHC appended with a poly(ethylene glycol) (PEG) block, and a modified poly(isobutylene-alt-maleic anhydride), PIMA, that simultaneously presents multiple NHC groups and several short PEG chains. In this report, we find that all three ligands can rapidly coordinate onto AuNPs, as characterized using a combination of NMR spectroscopy, high-resolution transmission electron microscopy, and dynamic light scattering. These measurements have been supplemented with colloidal stability tests as well as competition from dithiothreitol mols. Overall, we find that multidentate NHC polymer coating exhibits the highest affinity to AuNPs, which manifests in long-term colloidal stability in buffer media, absence of any aggregation, and better resistance to competition from reducing mols. We further exploit these data to infer addnl. insights into the interaction and coordination of NHC mols. with Au surfaces. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to heterocyclic carbene stabilized gold nanoparticle ligand, Placeholder for records without volume info and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 20, 2022, Bai, Jie; Wang, Jie; Feng, Yecheng; Yao, Yongfang; Zhao, Xubo published an article.Electric Literature of 5036-48-6 The title of the article was Stability-tunable core-crosslinked polymeric micelles based on an imidazole-bearing block polymer for pH-responsive drug delivery. And the article contained the following:

Polymeric micelles from block copolymers have gained increasing attention in cancer drug delivery. However, the fabrication of polymeric micelles that are stable in biol. fluids and unstable at tumor sites remains a principal challenge. To achieve the tunable stability for the polymeric micelles, Zn coordination-induced core-crosslinked polymeric micelles have been proposed and confirmed. Herein, a block copolymer bearing imidazole pendants is synthesized which is capable of self-assembling into polymeric micelles in water. After core-crosslinking, it can be found that the critical micelle concentration (CMC) of the core-crosslinked polymeric micelles is significantly lower than that of non-crosslinked polymeric micelles. Particularly, the drug-loaded core-crosslinked polymeric micelles are fragile and easily affected by the slightly acidic environments, which makes it possible to turn the polymeric micelles back to hydrophilic polymers and therefore disassemble micelles to unload cargoes. The drug-loaded core-crosslinked polymeric micelles display adequate toxicity as a result of their low IC50 value of 3.713 �0.166 渭g/mL. Collectively, Zn coordination-induced core-crosslinked polymeric micelles offer a design idea for practicable drug delivery system in cancer therapy. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to imidazole block polymer micelle drug delivery systems, Placeholder for records without volume info and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Liu, Dan; Xue, Aiqi; Wang, Haifeng; Luan, Tian; Li, Xue published an article in 2022, the title of the article was Design, synthesis and biological evaluation of 4-amino-quinolines as antitumor agents.Recommanded Product: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Fifteen novel 4-amino-quinolines (I1-III3) as antitumor agent were synthesized by p-nitroaniline and ethoxymethylene malonic ester (EMME) via condensation, cyclization, hydrolysis, decarboxylation, chlorination, nucleophilic substitution, reduction and amidation. The antitumor activity of compounds I1-III3 was evaluated on SGC-7901, BEL-7402 and A549 cancer cell lines. In vitro bioassay indicated that some compounds showed different degree activity against all tested cancer cell lines. Compound I1, I4 and II2 exhibited high effects against A549 cell lines (IC50 = 1.34渭M, 1.36渭M and 3.00渭M, resp.). In addition, the result of mol. docking showed that compound I1, I4 and II2 could dock into the pocket of EGFR. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to amino quinoline antitumor agent egfr receptor, Placeholder for records without volume info and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mothukuri, Ganesh K.; Kale, Sangram S.; Stenbratt, Carl L.; Zorzi, Alessandro; Vesin, Jonathan; Bortoli Chapalay, Julien; Deyle, Kaycie; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian published an article in 2020, the title of the article was Macrocycle synthesis strategy based on step-wise “adding and reacting” three components enables screening of large combinatorial libraries.Category: imidazoles-derivatives And the article contains the following content:

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three building blocks are coupled sequentially in efficient alkylation reactions that eliminate the need for product purification We demonstrate the power of the approach by combinatorially reacting 15 bromoacetamide-activated tripeptides, 42 amines, and 6 bis-electrophile cyclization linkers to generate a 3780-compound library with minimal effort. Screening against thrombin yielded a potent and selective inhibitor (Ki = 4.2 �0.8 nM) that efficiently blocked blood coagulation in human plasma. Structure-activity relationship and X-ray crystallog. anal. revealed that two of the three building blocks acted synergistically and underscored the importance of combinatorial screening in macrocycle development. The three-component library synthesis approach is general and offers a promising avenue to generate macrocycle ligands to other targets. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Category: imidazoles-derivatives

The Article related to plasma thrombin prothrombin thromboplastin x, Placeholder for records without volume info and other aspects.Category: imidazoles-derivatives

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tang, Shengzhuang; Chen, Jesse; Cannon, Jayme; Cao, Zhengyi; Baker, James R. Jr; Wang, Su He published an article in 2021, the title of the article was Dendrimer-based posaconazole nanoplatform for antifungal therapy.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

We examined formulating a new antifungal agent, posaconazole (POS) and its derivatives, with different mol. vehicles. Several combinations of drug and carrier mols. were synthesized, and their antifungal activities were evaluated against Aspergillus fumigatus. Posaconazole and four of its derivatives were conjugated to either generation 5 (G5) dendrimers or partially modified G5 dendrimers. The in vitro antifungal activities of these compounds suggest that conjugates with specific chem. linkages showed better fungistatic activity than direct conjugates to POS. In particular, a polyethylene glycol (PEG)-imidazole modified G5 dendrimer demonstrated improved antifungal efficacy relative to the parent G5 mol. Further studies were then conducted with POS derived mols. coupled to PEG-imidazole modified G5 dendrimers to achieve a highly soluble and active conjugate of POS. This conjugated macromol. averaged 23 POS mols. per G5 and had a high solubility with 50 mg/mL, which improved the molar solubility of POS from less than 0.03 mg/mL to as high as 16 mg/mL in water. The primary release profile of the drug in human plasma was extended to over 72 h, which is reflected in the in vitro inhibition of A. fumigatus growth of over 96 h. These POS-polymer conjugates appear to be novel and efficient antifungal agents. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to posaconazole nanoplatform dendrimer antifungal therapy, demethylase inhibitor, antifungal drug, biocompatible, polymer, Placeholder for records without volume info and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhang, Geping; Lu, Dandan; Yin, Keyang; Godbert, Nicolas; Dong, Renhao; Li, Hongguang; Hao, Jingcheng published an article in 2022, the title of the article was Alkylated, naphthalimide-containing ionic compounds with rich thermotropic behaviour and nonlinear optical response.Recommanded Product: 5036-48-6 And the article contains the following content:

Chem. functionalization of �conjugated units plays a key role in fine tuning their supramol. organizations and functions. Herein, five 1,8-naphthalimide derivatives were prepared where the naphthalimide moiety was attached to the imidazolium ring through a Pr linker. On the other side, the imidazolium ring was modified with either a branched aliphatic chain of 2-ethyl-hexyl (C2C6, 1), 2-hexyl-decyl (C6C10, 2) and 2-decyl-tetradecyl (C10C14, 3), or a linear aliphatic chain of octyl (C8, 1� and hexadecyl (C16, 2�. Temperature-dependent structural evolution of these alkylated, naphthalimide-modified imidazolium bromides (abbreviated to a-NaphImiBrs hereafter) were investigated in detail by differential scanning calorimetry and small-angle X-ray scattering measurements as well as polarized optical microscopy observations. The compound with the shortest branched aliphatic chain (1) self-organized into a columnar oblique (Colo) phase at room temperature, which changed to a columnar rectangular (Colr) phase upon heating. In comparison, its counterpart with a linear aliphatic chain of the same carbon number (1� formed a crystal at room temperature, which shifted to a Colo phase at elevated temperature The compound with a medium branched aliphatic chain (2) showed a columnar hexagonal (Colh) organization at room temperature, which changed to a smectic (Sm) phase upon heating. Compounds with longer aliphatic chains (2� 3), regardless of whether branched or linear, only exhibit the Sm phase. Films of a-NaphImiBrs formed at room temperature were subjected to evaluations for their nonlinear optical (NLO) responses where reverse saturated absorption was observed in all the cases. It was found that 2 showed the best NLO response with a third order nonlinear absorption coefficient of up to 0.49 cm W-1. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to alkylated naphthalimide containing ionic compound rich thermotropic behavior, nonlinear optical response, Placeholder for records without volume info and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem