Category: 492-98-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 492-98-8, name is 1H,1’H-2,2′-Biimidazole, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1H,1’H-2,2′-Biimidazole

A mixture of 14 Na2WO4 (0.329g, 1.00mmol), 15 H3PO4 (0.147g, 1.50mmol), 16 H2C2O4 (0.270g, 1.00mmol), 17 Cu(CH3OO)2 (0.356g, 1.50mmol), biim (0.067g, 0.50mmol), 18 TEA (0.03g, 0.50mmol) and 19 H2O (20ml) were stirred for 30min, then 20 NH3·H2O was added to adjust the pH value to 6.5. Finally, the suspension was transferred to a 30ml Teflon-lined autoclave and heated at 160C for 120h under autogenous pressure. After the system was cooled to room temperature, black block crystals were filtered and dried at room temperature. Yield: 62.5% (based on W). Anal. Calcd. for C48H90Cu4N20O82P2W24: C, 8.25; H, 1.30; N, 4.01; W, 63.13; Cu, 3.64; P, 0.89. Found: C, 8.28; H, 1.25; N, 4.06; W, 63.02; Cu, 3.73; P, 0.87. IR (cm-1): 3447, 3302, 1642, 1566, 1514, 1414, 1090, 1063, 965, 879, 818, 785, 677

According to the analysis of related databases, 492-98-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shi, Shu-Yun; Chen, Ling-Yu; Zhu, Tong-Hui; Zhang, Jun; Cui, Xiao-Bing; Inorganica Chimica Acta; vol. 477; (2018); p. 292 – 299;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 492-98-8, A common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, molecular formula is C6H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthetic example 11 :1 ,r-bis(4-bromobenzyl)-1H,1 ‘H^’-biimidazole11To a mixture of 1H,1 W-2,2′-biimidazole (2.1 g, 15.7 mmol) in DMF at 0 “C was added NaH (1.32 g of a 60% dispersion in mineral oil, 32.8 mmol). The mixture was allowed to warm to room temperature and stirred for 30 min. 1-bromo-4- (bromomethyl)benzene (11.7 g, 46.8 mmol) was added and the mixture was heated to 80 “C and stirred (2h). The mixture was cooled to room temperature and saturated aqueous NH4CI (2 mL) was added and the mixture was concentrated. The mixture was diluted with CH2CI2 and Eta20 and the organic phase was separated. The aqueous phase was re-extracted (CH2CI2) and the combined organics were washed (saturated aqueous NaCI), dried (MgS04), filtered and concentrated to give a solid residue. The residue was purified by flash chromatography (EtOAc/CH2CI2 0:100 then 50:50 then 80:20) to give l .l’-bisi^bromobenzy -I ^^’-biimidazole (4.12 g, 56%) as a colourless solid. 1H NMR (CDCI3) 400 MHz) delta 5.66 (s, 4H), 6.86 -.6.91 (m, 4H), 6.93 (d( J 1.2 Hz, 2H), 7.11 (d, J 1.2 Hz, 2H), 7.33 – 7.39 (m, 4H); 13C NMR (CDCI3, 100 MHz) 5 50.2, 121.5, 121.7, 128.5, 129.1 , 131.8, 136.3, 138.0; HRMS (El) m/z 469.9741 C2oHi6 4Br2 [M]+” requires 671.2918.

The synthetic route of 492-98-8 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 492-98-8

A mixture of Zn(NO3)2 6H2O (44.6mg,0.15mmol),5-Brnic(60.6 mg,0.3mmol),H2biim (20.1mg,0.15mmol),NaOH(12.0mg,0.3 mmol),and H2O (10mL)was stirred at room temperature for 15min,and then sealed in a25mL Teflon-lined stainless steel vessel,and heated at 160 1C for 3days,followed by cooling to room temperature at a rate of 10 1C/h. Colorless block-shaped crystals were isolated manually,and washed with distilled water.Yield: 55%(basedon5-BrnicH).CalcdforC24H14Br2ZnN4O4:C 44.51%,H2.18%,N8.65%.Found:C44.17%,H1.84%,N8.24%.IR (KBr,cm1): 1609vs,1552m,1441m,1394w,1370vs,1342w,1281m,1237w,1181w,1125s,1088w,1028m,991w,925w,887w,862w,771m,754m,732m,687m,553w,and434w.

The synthetic route of 1H,1’H-2,2′-Biimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gu, Jin-Zhong; Wu, Jiang; Kirillov, Alexander M.; Lv, Dong-Yu; Tang, Yu; Wu, Jin-Cai; Journal of Solid State Chemistry; vol. 213; (2014); p. 256 – 267;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1H,1’H-2,2′-Biimidazole

A methanol solution (10 mL) of Cu(ClO4)2¡¤6H2O (0.33 g, 2 mmol) was initially reacted with acetylacetone (0.02 g, 2 mmol) treated with NaOH (0.040 g, 1.0 mmol) in water (10 mL) under magnetic stirring at room temperature. After 30 min, a 20 mL methanolic solution of the biimidazole (0.15 g, 2 mmol) was added to the solution and the resulting mixture was stirred for 2 h at room temperature. The green colored solid was isolated and washed with cold aqueous methanol and finally dried over P4O10 (Yield: 67%).

The synthetic route of 1H,1’H-2,2′-Biimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nagasubramanian, Soundarajan; Thamilarasan, Vijayan; Jayamani, Arumugam; Kang, Sung Kwon; Kim, Young-Inn; Sengottuvelan, Nallathambi; Bulletin of the Korean Chemical Society; vol. 34; 6; (2013); p. 1875 – 1878;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 492-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 492-98-8, name is 1H,1’H-2,2′-Biimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of Na2MoO4*2H2O (0.0718 g, 0.296 mmol), 2,2′-biimidazole (biim, 0.0430 g, 0.257 mmol), NiF2*4H2O (0.0095 g, 0.056 mmol), and Na2SiO3*9H2O (0.0708 g, 0.249 mmol) in H2O (10 mL) was adjusted to pH 2.5 with HCl (1.0 mol/L solution in water) and heated at 150 C for 48 h in a sealed 25 mL teflon-lined stainless vessels under autogenous pressure. After cooling to ambient temperature with 800 min, black block crystals (yield50%, based on Na2MoO4*2H2O) were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H,1’H-2,2′-Biimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Hao; Chen, Yi-Ping; You, Zhu-Chai; Zhou, Meng-Xi; Zhang, Ning; Sun, Yan-Qiong; Chinese Chemical Letters; vol. 26; 2; (2015); p. 187 – 192;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 492-98-8, name is 1H,1’H-2,2′-Biimidazole, A new synthetic method of this compound is introduced below., Formula: C6H6N4

Synthetic example 10:1 , 1 ‘-bis(6-methyl-9-p-tolyl-9H-carbazol-3-y.)-1 H, 1 ,H-2,2i-biimidazole10A mixture of 1W, W-2,2*-biimidazole (890 mg, 6.6 mmol), 3-bromo-6-methyl-9-p-tolyl- 9H-carbazole (6.49 g, 18.6 mmol) and Cs2C03 (7.55 g, 23.2 mmol) in D F (80 mL) was degassed (N2 bubbling, 15 min). Cu20 (380 mg, 2.7 mmol) was added and the mixture was heated (140 C, 96h). The mixture was allowed to cool to room temperature and filtered through Celite washing with CH2CI2. The combined filtrate and washings were concentrated. The mixture was diluted with CH2CI2 and H2O and the organic phase was separated. The aqueous phase was re-extracted (CH2CI2) and the combined organics were washed (saturated aqueous NaCI), dried (MgS04), filtered and concentrated to give a solid residue. The residue was purified by flash chromatography (EtOAc CH2CI2/ eOH 39:60:1 then 37:60:3 then 35:60:5) to give l.r-bisie-methyl-g-p-tolyl-gH-carbazol-S-y -IH.rH^^’-biimidazole (1.42 g, 32%) as a colourless solid. A portion of this material was further purified firstly, by recrystallisation (CH2CI2/toluene/petrol) and then by distillation (sublimation apparatus 270 C, 1CT6 mBar): m.p. 208 – 214 C (DSC); 1H N R (CDCI3, 400 MHz) delta 2.38 (s, 6H), 2.49 (s, 6H), 6.71 (dd, J 1.8, 8.7 Hz, 2H), 7.03 (d, J 8.6 Hz, 2H), 7.05 – 7.20 (m, 8H), 7.23 – 7.40 (m, 12H); 13C NMR (CDCI3, 100 MHz) 5 21.2, 21.3, 109.4, 109.4, 115.7, 119.7, 121.8, 122.4, 123.1, 126.5, 127.8, 129.3, 129.6, 130.4, 134.6, 137.4, 139.6, 139.7; HRMS (El) m/z 671.2916 C46H35 6 [M – Hf* requires 671.2918

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; MACDONALD, James Matthew; BOWN, Mark; UENO, Kazunori; WEBER, Karl Peter; O’CONNELL, Jenny Lee; HIRAI, Tadahiko; WO2012/51666; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

492-98-8, name is 1H,1’H-2,2′-Biimidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1H,1’H-2,2′-Biimidazole

Example 14: Synthesis of (tetrakis(1-phenylpyrazolato)(mu-biimidazolyl) diiridium(III), Abbreviation; [Ir(ppz)2BIm]2) [0300] [0301] Under argon atmosphere, into a 100 mL Schlenk flask equipped with a stirrer were placed 308 mg (0.30 mmol) of di-mu-chloro-tetrakis(1-phenylpyrazolato) diiridium(III), 40 mg (0.30 mmol) of 2,2′-biimidazole and 60 ml of tetrahydrofuran. And then, the mixture was stirred at room temperature for 7 hours. Subsequently, 83 mg (0.63 mmol) of tert-butoxy potassium (t-BuOK (85 wt% product)) was added to the mixture, and the mixture was reacted under stirring at room temperature for 16 hours. After the completion of the reaction, tetrahydrofuran was distilled off under reduced pressure, and then methylene chloride was added to the residue, and the insoluble substance was removed by filtration. The filtrate was concentrated under reduced pressure. The resultant crude reaction product was subjected to column chromatography with alumina (developing solvent: methylene chloride : 0.5 % triethylamine) for purification, to provide 180 mg of the desired compound as a pale ocher solid. (Isolation yield: 55 %) Additionally, tetrakis(1-phenylpyrazolato)(mu-biimidazolyl) diiridium(III) was a novel compound, which had the following properties: [0302] 1H-NMR (400MHz, CD2Cl2, delta (ppm)); 8.35 (dd, 4H), 7.29 (dd, 4H), 6.76-6.80 (m, 8H), 6.61-6.56 (m, 4H), 6.50-6.48 (m, 4H), 6.39-6.39 (dd, 4H), 6.18 (s, 4H) FD-MS (M/Z): 1088 M+

The synthetic route of 492-98-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ube Industries, Ltd.; FUJIMURA, Osamu; FUKUNAGA, Kenji; IWASA, Takafumi; TANAKA, Yasuhiro; FUJITA, Harunori; MURAKAMI, Tadashi; HONMA, Takashi; MACHIDA, Toshikazu; KASHIHARA, Natsuko; EP2647642; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H6N4

General procedure: A mixture of H2ATIBDC (0.084 g, 0.150 mmol) and NaOH (0.3 ml, 0.5 mol/l) was dissolved in water (5 ml) and then an aqueous solution of CdCl2¡¤2.5H2O (0.034 g, 0.150 mmol) in water (5 ml) was added whilst stirring. To this solution biim (0.008 g, 0.050 mmol) in methanol (5 ml) was added and then filtered. The compound was obtained from the filtrate with a 68% yield based on H2ATIBDC.

The synthetic route of 1H,1’H-2,2′-Biimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Lei; Wei, Yan; Zhong, Ya-Qiang; Chang, Yan; Meng, Qing-Hua; Ng, Seik Weng; Zhang, Kou-Lin; Inorganica Chimica Acta; vol. 435; (2015); p. 7 – 15;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, molecular formula is C6H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H6N4

2,2′-Biimidazole (0.33 g, 2.48 mmol) and NaOH (0.39 g, 9.92 mmol) were placed in a 100 mL round bottomed flask with 20 mL of acetonitrile. The mixture was stirred at room temperature for two hours. Benzyl bromide (0.63 g, 5 mmol) in acetonitrile (20 mL) was added to the mixture and refluxed for 24 h at 50-60 C. The reaction was monitored with TLC and after completion the solvent was removed by rotary evaporation. The residue was dissolved in water (50 mL) and extracted with methylene chloride (30 mL * 3). Organic layers were combined, dried over anhydrous MgSO4 and rotary evaporated to obtain the yellow color powder as the product. Yield: 0.69 g (89%); mp 144-146 C; 1H NMR (deltaH; CDCl3, 400 MHz):5.70 (s, 4H), 6.93 (d, 2H), 7.03 (m, 4H), 7.12 (d, 2H), 7.24 (m, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 492-98-8, its application will become more common.

Reference:
Article; Aakeroey, Christer B.; Wijethunga, Tharanga K.; Desper, John; Journal of Molecular Structure; vol. 1072; 1; (2014); p. 20 – 27;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 492-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 492-98-8, name is 1H,1’H-2,2′-Biimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 16: Synthesis of (tetrakis(2-phenylpyridinato)(mu-biimidazolyl) diiridium(III), Abbreviation; [Ir(ppy)2BIm]2) [0307] [0308] Under argon atmosphere, into a 100 mL Schlenk flask equipped with a stirrer were placed 322 mg (0.30 mmol) of di-mu-chloro-tetrakis(2-phenylpyridinato) diiridium(III), 40 mg (0.30 mmol) of 2,2′-biimidazole and 60 ml of tetrahydrofuran. And then, the mixture was stirred at room temperature for 13 hours. Subsequently, 83 mg (0.63 mmol) of tert-butoxy potassium (t-BuOK (85 wt% product)) was added to the mixture, and the mixture was reacted under stirring at room temperature for 24 hours. After the completion of the reaction, tetrahydrofuran was distilled off under reduced pressure, and then methylene chloride was added to the residue, and the insoluble substance was removed by filtration. The filtrate was concentrated under reduced pressure. The resultant crude reaction product was subjected to column chromatography with alumina (developing solvent: methylene chloride / hexane (volume ratio; 3/1) : 0.5 % triethylamine) for purification, to provide 113 mg of the desired compound as a yellow solid. (Yield: 33 %) The desired compound obtained was a mixture of isomers, and the product ratio was Isomer 1 (main product) : Isomer 2 = 61:39. [0309] Additionally, tetrakis(2-phenylpyridinato)(mu-biimidazolyl) diiridium(III) was a novel compound, which had the following properties: [0310] 1H-NMR (400MHz, C4D8O, delta (ppm)) Isomer 1; 8.18 (dd, 4H), 7.86 (d, 4H), 7.70-7.55 (m, 8H), 6.81-6.72 (m, 8H), 6.66-6.62 (m, 4H), 6.38 (dd, 4H), 6.11 (s, 4H) Isomer 2; 7.92 (d, 4H), 7.78 (dd, 4H), 7.70-7.55 (m, 8H), 6.81-6.72 (m, 8H), 6.66-6.62 (m, 4H), 6.32 (dd, 4H), 6.13 (s, 4H) FD-MS (M/Z): 1132 M+

The synthetic route of 1H,1’H-2,2′-Biimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ube Industries, Ltd.; FUJIMURA, Osamu; FUKUNAGA, Kenji; IWASA, Takafumi; TANAKA, Yasuhiro; FUJITA, Harunori; MURAKAMI, Tadashi; HONMA, Takashi; MACHIDA, Toshikazu; KASHIHARA, Natsuko; EP2647642; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem