4887-94-9, name is 2-Chloro-5-methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Chloro-5-methyl-1H-benzo[d]imidazole
10 g of 2-chloro-5-methyl-1H-benzo[d]imidazole was added to 130 ml of N,N-dimethylformamide,Add 15g of anhydrous potassium carbonate and 9g of piperidine-4-carboxylic acid,Heated at reflux for 2 hours,cool down,Add water and ethyl acetate extractionLiquid separation,Collect the organic phase,concentrate,The residue was separated on a silica gel column to give 7 g of 1-(5-methyl-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid.
The synthetic route of 4887-94-9 has been constantly updated, and we look forward to future research findings.