4887-83-6 Archives - Page 2 of 2 - Imidazoles-derivatives

Gujjarappa, Raghuram et al. published their research in Asian Journal of Organic Chemistry in 2020 | CAS: 4887-83-6

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C8H8N2

A Facile C-H Insertion Strategy using Combination of HFIP and Isocyanides: Metal-Free Access to Azole Derivatives was written by Gujjarappa, Raghuram;Vodnala, Nagaraju;Reddy, Velma Ganga;Malakar, Chandi C.. And the article was included in Asian Journal of Organic Chemistry in 2020.Synthetic Route of C8H8N2 This article mentions the following:

An efficient metal-free approach has been devised towards the synthesis of azoles via C-H insertion protocol. Various isocyanides were examined as effective C1-synthons. The HFIP plays crucial role as hydrogen source and promoter of the reaction in order to reveal the maximum efficacies to accomplish the transformation in high yields of the products with excellent functional group tolerance. The control experiment affirmed 83% of deuterium incorporation, when the reaction was performed using HFIP-d₂. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Synthetic Route of C8H8N2).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C8H8N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dar, Bashir Ahmad et al. published their research in Tetrahedron Letters in 2013 | CAS: 4887-83-6

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 7-Methyl-1H-benzo[d]imidazole

Ultrasound promoted expeditious, catalyst-free and solvent-free approach for the synthesis of N,N’-diaryl-substituted formamidines at room temperature was written by Dar, Bashir Ahmad;Ahmad, Syed Naseer;Wagay, Mohammad Arif;Hussain, Altaf;Ahmad, Nisar;Bhat, Khursheed Ahmad;Khuroo, Mohammad Akbar;Sharma, Meena;Singh, Baldev. And the article was included in Tetrahedron Letters in 2013.Name: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

An effortless and efficient protocol was developed for the synthesis of N,N’-diaryl formamidines by three-component condensation of primary aromatic amines with HC(OEt)₃ under environment-friendly conditions. Ultrasonic energy was employed to obtain the desired products in excellent yields with high purity under solvent-free and catalyst-free conditions. Products were purified by crystallization to avoid excess utilization of organic solvents. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Name: 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mizuno, Cassia S. et al. published their research in Medicinal Chemistry Research in 2009 | CAS: 4887-83-6

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 4887-83-6

Design, synthesis, and docking studies of telmisartan analogs for the treatment of metabolic syndrome was written by Mizuno, Cassia S.;Chittiboyina, Amar G.;Patny, Akshay;Kurtz, Theodore W.;Pershadsingh, Harrihar A.;Speth, Robert C.;Karamyan, Vardan T.;Avery, Mitchell A.. And the article was included in Medicinal Chemistry Research in 2009.Recommanded Product: 4887-83-6 This article mentions the following:

In our early studies, telmisartan was found to be a moderate peroxisome proliferator-activated receptor (PPAR) gamma activator in the human PPARγ-GAL-4 cell-based transactivation assay. Thus, novel analogs of telmisartan were designed, synthesized, and evaluated in the AT₁ receptor binding assay and PPAR gamma transactivation assay. A total of 11 compounds were designed based on docking in both AT₁ receptor model and PPAR gamma active pocket and synthesized. Introduction of an addnl. acidic group at the para position of the distal Ph ring of telmisartan decreased affinity towards AT₁ receptor and PPARγ activity. In the present study, the mol. with best results was I, with weak PPARγ activity (8% of maximum PPARγ activation achieved by full agonist rosiglitazone at 10 μM) and good binding affinity (K_i = 650 ± 139 nM) towards the AT₁ receptor. Docking of I into AT₁ receptor model and PPAR gamma showed very similar interactions with the receptors as AT₁ antagonist telmisartan and PPAR gamma agonist rosiglitazone. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Recommanded Product: 4887-83-6).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new synthetic route of 4887-83-6

The synthetic route of 4887-83-6 has been constantly updated, and we look forward to future research findings.

Reference of 4887-83-6, A common heterocyclic compound, 4887-83-6, name is 7-Methyl-1H-benzo[d]imidazole, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 8 2-[(4-methyl-1H-benzo[d]imidazol-1-yl)methyl]-3-phenyl-4H-chromen-4-one To a solution of intermediate 5 (0.10 g, 0.317 mmoles) in dioxan (2 ml), was added 4-methylbenzimidazole (0.083 g, 0.634 mmoles) at RT and refluxed for 12 h. The reaction mixture was cooled, diluted with aqueous bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography with methanol:dichloromethane to afford the title compound as yellow solid (0.060 g, 51% yield). MP: 204-208 C. 1H-NMR (delta ppm, DMSO-D6, 400 MHz): delta 8.11 (s, 1H), 8.04 (d, J=7.6 Hz, 1H), 7.77 (t, J=7.6 Hz, 1H), 7.55 (m, 7H), 7.08 (t, J=8.0 Hz, 1H), 6.99 (d, J=7.6 Hz, 2H), 5.40 (s, 2H), 2.48 (s, 3H). Mass: 367.25 (M++1).

The synthetic route of 4887-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd.; US2011/118257; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Share a compound : 4887-83-6

The synthetic route of 4887-83-6 has been constantly updated, and we look forward to future research findings.

4887-83-6, name is 7-Methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4887-83-6

4-Methyl-1 H-benzimidazole (328 mg; APAC) was dissolved in DCM (7 ml_), di-te/f-butyl dicarbonate (0.634 ml.) was added and the solution was stirred at RT for 18 hr. The solvent was evaporated to give the title compound (575 mg) as a yellow oil. It was used without further purification, m/z [M+H]+: 233.2. Retention time 1.18 min (LC/MS method 3

The synthetic route of 4887-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brief introduction of 4887-83-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Methyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Related Products of 4887-83-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4887-83-6 name is 7-Methyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1 -chloro-5-fluoro-3,3,4,4-tetramethyl-isoquinoline (1 .67 mmol, 0.430 g) in pyridine (0.20 M, 9.0 mL) at room temperature was added 4-methyl-1 H-benzimidazole (1 .5 equiv., 2.69 mmol, 0.356 g) and the mixture was stirred at 90 C for 15 hours. The reaction mixture was allowed to cool down to room temperature and then concentrated under vacuo. The residue obtained was purified by flash chromatography to give 5-fluoro-3,3,4,4- tetramethyl-1 -(4-methylbenzimidazol-1 -yl)isoquinoline (0.525 g, 87% yield) as a beige solid : mp= 1 18-120C, LC-MS (Method G) UV Detection: 220 nm, Rt = 1 .19, MS: (M+1 ) = 336; 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1 .32 (s, 6 H) 1 .47 (s, 6 H) 2.71 (s, 3H) 6.91 -6.95 (m, 1 H) 7.10 – 7.25 (m, 5 H) 8.18 (s, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Methyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; BOU HAMDAN, Farhan; QUARANTA, Laura; TRAH, Stephan; WEISS, Matthias; (101 pag.)WO2016/156085; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Discovery of 7-Methyl-1H-benzo[d]imidazole

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

4887-83-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4887-83-6, name is 7-Methyl-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below.

B. 4-Methylbenzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester A solution of 4-methylbenzimidazole (810 mg, 6.1 mmol), N,N-dimethylaminopyridine (75 mg, 0.6 mmol) and di-tert-butyl dicarbonate (1.54 g, 7.1 mmol) in acetonitrile (20 mL) was stirred at room temperature for 15 min. The solvent was evaporated and the residue was chromatographed (10% ethyl acetate/hexanes) to give 4-methylbenzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (1.35 g, 95%).

Reference:
Patent; Hoffmann-La Roche Inc.; US6331640; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem