Category: 4887-83-6

Michael adducts in the regioselective synthesis of N-substituted azoles was written by Horvath, Andras. And the article was included in Synthesis in 1995.Quality Control of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Michael adducts of azoles (4-phenyl-, 4-methyl-, and 4-nitroimidazole, 4-methylbenzimidazole, 1,2,4-triazole, and theophylline) are shown to be valuable substrates for obtaining the N-substituted derivatives of the parent heterocycles by a quaternization-Hofmann elimination sequence. The effectiveness of the procedure is dependent on the regiochem. outcome of the 1st, N-protective step, i.e. the Michael addition By choosing the appropriate Michael acceptor, alkylating agent, and deprotection conditions, the thermodynamically less stable regioisomers of N-substituted azoles were obtained in high yields. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Quality Control of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The infrared spectra of some simple benzimidazoles was written by Morgan, K. J.. And the article was included in Journal of the Chemical Society in 1961.Related Products of 4887-83-6 This article mentions the following:

The spectra of solid specimens of the simple alkyl and perfluoroalkylbenzimidazoles are characterized by a series of strong, broad bands in the region 2400-3200 cm.^-1 They show no band in the region normally associated with the simple N-H stretching frequency. The alkyl and perfluoroalkyl groups are 2-Me, Et, 2-Pr, 2-iso-Pr, 4-Me, 5-Me, 2,5-Me₂, 2-CF₃, 2-C₂F₅, 2-C₃F₇, 4-CF₃, 5-CF₃, 2-Me-4-CF₃, 4-Me-2-CF₃, 4-Me-₂-Pr, 2,4-(CF₃)₂, 2,5-(CF₃)₂, 2-Me-4,5-(CF₃)₂ 2,4,5-(CF₃聽₃, 5-MeO-2-CF₃, 4,5,6,7-F₄-2-CF₃. Strong bands near 2400-3200 cm.^-1 are ascribed to a strong H bond of the type N-H. . .N, showing proton transfer. The position of the N-H bands of the spectra of solutions of benzimidazoles is similar to that found for pyrroles and indoles. The bands show typical displacements when tetrachloroethylene replaces CH₂Cl₂ as solvent. Small increases in the frequency of the alkyl derivatives and large decreases in frequency of the perfluoroalkyl compounds diminish as the orientation of substitution varies 2 > 4 鈮?5. These shifts are mainly due to induction, and there is little H bonding to adjacent F atoms. Compounds with perfluoralkyl substituents show more intense absorption, giving higher values of extinction coefficients and broader bands. Spectra of perimidine, 2-methyl-, 2-ethyl-, and 2-propylperimidine show broad banded absorption from 2400 to 3200 cm.^-1 In solution spectra these bonded IV-H bands are replaced by sharp bands near 3400 cm.^-1 Benzimi- dazole-2-acetic acid and difluoroacetic acid have spectra indicating a strongly bonded carbonyl group and discrete OH and NH groups. In 尾-(2-benzimidazolyl)propionic acid the carbonyl is replaced by a broad band at 1550 cm.^-1 and the C-O stretching frequency is displaced to 1410 cm.^-1 This compound is regarded as zwitterionic. 2-Benzimidazolecarboxylic acid has a bonded carbonyl group but shows no discrete OH or amino bonds. 5-Trifluoromethyl-2-benzimidazolecarboxylic acid is similar, and a low carbonyl frequency suggests that the 4-trifluoromethyl analog is best written as a nonbonded compound In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Related Products of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supercritical methanol as solvent and carbon source in the catalytic conversion of 1,2-diaminobenzenes and 2-nitroanilines to benzimidazoles was written by Sun, Zhuohua;Bottari, Giovanni;Barta, Katalin. And the article was included in Green Chemistry in 2015.HPLC of Formula: 4887-83-6 This article mentions the following:

Benzimidazoles and N-methylbenzimidazoles were synthesized by simply heating 1,2-diaminobenzenes in supercritical methanol over copper-doped porous metal oxides. These catalysts were derived from synthetic hydrotalcites that only contain earth-abundant starting materials. The carbon equivalent needed for the construction of the benzimidazole core originated from the solvent itself, which is known to undergo reforming to hydrogen and carbon monoxide through the formation of a formaldehyde intermediate. A variety of 1,2-diaminobenzenes were converted to the corresponding mixtures of benzimidazoles and N-methylated analogs in good yields. Interestingly, the more challenging, but readily available 2-nitroanilines, which require an addnl. reduction step prior to cyclization, could also be successfully converted to benzimidazoles in high selectivity. Furthermore, various other alcs. were applied besides methanol, to obtain 2-alkyl- and 1,2-dialkylbenzimidazoles. Preliminary mechanistic insights into the origins of N-alkylation as well as the reactivity of the nitro derivatives are discussed. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

NMR studies on heterocycle chemistry. XXII. Carbon-13 nuclear magnetic resonance study on benzimidazole derivatives was written by Fruchier, A.;Pappalardo, L.;Elguero, J.. And the article was included in Anales de Quimica, Serie C: Quimica Organica y Bioquimica in 1980.HPLC of Formula: 4887-83-6 This article mentions the following:

The ¹³C NMR chem. shifts of benzimidazoles I (R = Me, Cl, NO₂; n = 0-2; R¹ = H or Me) and of corresponding 1,3-dimethylbenzimidazolium salts were measured. The effect of substituents on the shifts were calculated Equilibrium constants were determined for tautomerism of 5 I (R¹ = H). In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6HPLC of Formula: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A highly effective sulfamic acid/methanol catalytic system for the synthesis of benzimidazole derivatives at room temperature was written by Zhang, Zhan-Hui;Li, Tong-Shuang;Li, Jian-Jiong. And the article was included in Monatshefte fuer Chemie in 2007.Safety of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Sulfamic acid/methanol was an efficient catalytic system for the synthesis of benzimidazole compounds through the condensation of o-phenylenediamines with orthoesters in high yields at room temperature In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Safety of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ru@PsIL-Catalyzed Synthesis of N-Formamides and Benzimidazole by using Carbon Dioxide and Dimethylamine Borane was written by Saptal, Vitthal B.;Sasaki, Takehiko;Bhanage, Bhalchandra M.. And the article was included in ChemCatChem in 2018.Reference of 4887-83-6 This article mentions the following:

The synthesis and characterization of ruthenium nanoparticles (Ru NPs) supported on polymeric ionic liquids (PILs) was reported. This catalyst showed high catalytic activity towards the N-formylation of amines and synthesis of benzimidazoles from 1,2-diamines and carbon dioxide (CO₂) by reductive dehydrogenation of dimethylamine borane. This methodol. showed excellent functional group tolerance with broad substrate scope towards the synthesis of N-formamides and benzimidazoles. Interestingly, this protocol also provided the tandem reduction of 2-nitroamines and CO₂ to synthesize benzimidazoles. It was proposed that the ionic liquid phase of the polymer played pivotal roles such as assisting the stabilization of nanoparticles electrostatically, providing an ionic environment, and controlling the easy access of the substrates/reagents to the active sites. The developed methodol. utilized CO₂ as a C₁ source and water/ethanol as a green solvent system. Addnl., the catalyst was found to be recyclable in nature and showed five consecutive recycling runs without significant loss in its activity. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Reference of 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Photoisomerization of indazoles to benzimidazoles was written by Tiefenthaler, H.;Dorscheln, W.;Goth, H.;Schmid, H.. And the article was included in Tetrahedron Letters in 1964.SDS of cas: 4887-83-6 This article mentions the following:

Indazole, 3-, 4-, 5-, 6-, or 7-methyl-, and 6-methoxyindazole irradiated with uv light (high pressure Hg lamp) in MeOH, EtOAc, or dioxane 3-20 hrs. at 25-90掳 were irreversibly converted in 9-31% yields to the corresponding benzimidazoles. The influence of solvent, reaction time, and temperature was tabulated. No isomerization was noted for 3-Ph-, 5-MeO-, 5-Cl-, and 6-Cl-substituted imidazoles. Pyrazole on irradiation in dioxane gave 12% imidazole. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6SDS of cas: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds was written by Moon, Malcolm W.;Morris, Jeanette K.;Heier, Richard F.;Chidester, Connie G.;Hoffmann, William E.;Piercey, Montford F.;Althaus, John S.;VonVoigtlander, Philip F.;Evans, Dawna L.. And the article was included in Journal of Medicinal Chemistry in 1992.Name: 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (I), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT_1A) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of I; the (S)-enantiomer shows no dopaminergic activity. A series of analogs where the imidazolone ring was modified to various 5- or 6-membered heterocyclic rings were prepared Some of these compounds showed a combination of dopaminergic and serotonergic activity, while one compound, 6-(dipropylamino)-1,2,6,7-tetrahydro-3H,5H-pyrido[3,2,1-ij]quinazolin-3-one (II), was a selective serotonergic agonist. Various analogs of I where the dipropylamine substituent was modified were prepared Most of these showed reduced dopaminergic activity, while several were as potent as I at the serotonin 5HT_1A receptor. Orientations for the new compounds at dopamine and serotonin receptors are proposed and compared with those of other tricyclic ligands known to have high affinity at these receptors. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Name: 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of substituents on the electronic structure and spectral characteristics of imidazole derivatives in the ground and excited states was written by Prokop’eva, T. M.;Vysotskii, Yu. B.;Dadali, V. A.;Sokolenko, V. A.. And the article was included in Ukrainskii Khimicheskii Zhurnal (Russian Edition) in 1982.SDS of cas: 4887-83-6 This article mentions the following:

Ground- and excited-state electron d. distributions were calculated for imidazole, benzimidazole, their protonated and anionic forms, and 1-phenylimidazole by the PMO LCAO SCF method. The results of the calculations corresponded to exptl. reactivity data. The lowest singlet-singlet transition energies were also calculated for benzimidazoles, and these agreed with exptl. spectra. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6SDS of cas: 4887-83-6).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 4887-83-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles was written by Lin, Sheng-Nan;Chen, Yu;Luo, Xiao-Dong;Li, Yi. And the article was included in European Journal of Organic Chemistry in 2021.Quality Control of 7-Methyl-1H-benzo[d]imidazole This article mentions the following:

Herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes e.g., I to afford highly functionalized polycyclic imidazoles e.g., II was reported. This method features a direct radical cyclization of imidazoles with alkenes e.g., I using BrCF₂R (R = C(O)OEt, N-cyclohexylcarbamoyl, (thiomorpholin-4-yl)carbonyl, etc.) as radical sources. The reaction conditions tolerate a wide range of substrate scope and afford the desired products e.g., II with up to 95% isolated yield under mild conditions. Radical-trapping and light-on/off experiments indicated a photocatalytic radical mechanism. In the experiment, the researchers used many compounds, for example, 7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6Quality Control of 7-Methyl-1H-benzo[d]imidazole).

7-Methyl-1H-benzo[d]imidazole (cas: 4887-83-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of 7-Methyl-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem