Reference of 4887-82-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4887-82-5 as follows.
Intermediate 2; M&lbgammal 5-{5~chloro-1 Mbe?2Jm.d8ZthetaJ-1-v.)-3-{[(1/?)-1-(2-chioro~ 3″hvdroxyphe?yi)ethy?oxy}-2-thiophe?ecaphiochiyiateStep A – Methyi 5-(5-chioro-1 AAbenzimida2ol-1-y.)-3-{[(1 ,1-dimethylethyl)- (climethy.)si.y.]oxy}-2-thiophenecarboxyiateTo a mixture of chiorobe?zimidazole (7,0 g, 48 mmol) and methyl 2-chloro-3- oxo-2,3-dihydro-2-thk>phenecarboxyiate (Synthesis,, 1984,, IQ1 847-850) (9.8 g, 51 mmol) in 400 mL of chloroform was added /V-methyiimidazoie (5.5 mL, 89 mmoi). After 16 h, fe/f-buiyfchlorodimethyisilane (8.9 g, 46 mmol) and lambdaA methylimidazoie (3.7 ml, 48 mmol) was added. The reaction mixture was diluted with water and the layers were separated. The aqueous phase was extracted with DCW. The combined organic layers were washed with water, dried over MgSO4 and concentrated onto silica gel The crude material was purified by flash column chromatography (0-100% 25% EtOAc/hexanes) to give 5,8 g of the desired product (30%). 1H NMR (400 MHz, Cl6-DMSO) delta 8.79 (ss 1H), 7.8S (ci, ,/ =2.0 Hz1 IH), 7.81 (d, J =%alpha HZ1 1H)1 7,44 (dd, J^8,8 and 2.0 Hz, 1H), 7,25 (s. 1H), 3.78 (s, 3H), 0.99 (s, 9H), 0.27 (s, QH).
According to the analysis of related databases, 4887-82-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/143456; (2007); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem