Category: 4887-80-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H8N2O

5-methoxybenzimidazole (0.296 g, 2 mmol), 2-(4-Diethylamino-2-hydroxy) benzoylbenzoic acid (0.626 g, 2 mmol) were mixed and addedinto concentrated H2SO4 (3 mL), heated at 100 C for 6 h, and thenslowly cooling to ambient temperature. The resulting mixture wasslowly poured into ice cold water, neutralized by saturated aqueousNaHCO3 followed by extraction with CH2Cl2 (50 mL×3). The organiclayers were collected and dried over Na2SO4, which was subsequentlyevaporated to remove CH2Cl2. Finally, target compound BiF was obtainedas a white powder in yield of 82.0% (0.768 g) through columnchromatography over silica gel eluting with CH2Cl2/CH3OH (v/v=20 :1). M.p.>300 C. ESI-HRMS: calcd. m/z 412.1661 for [M + H]+,found m/z 412.1615 for [M + H]+; 1H NMR (400 MHz, DMSO-d6) delta(ppm) 8.04 (dd, J=6.0 Hz, 2.2 Hz, 1H), 7.65-7.54 (m, 4H), 7.19 (d,J=8.8 Hz, 2H), 6.61 (d, J=8.8 Hz, 1H), 6.48 (d, J=2.4 Hz, 1H), 6.39(dd, J=8.8 Hz, 2.4 Hz, 1H), 3.67 (q, J=7.0 Hz, 4H), 1.18 (t,J=7.0 Hz, 6H). 13 C NMR (100 MHz, DMSO-d6) delta (ppm) 170.36,152.58, 149.65, 140.71, 135.12, 129.84, 128.52, 127.11, 125.28,124.10, 113.10, 108.68, 104.80, 97.57, 84.05, 44.61, 12.65.

According to the analysis of related databases, 4887-80-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Huang, Kun; Han, Defang; Li, Xianglin; Peng, Mengni; Zeng, Xianshun; Jing, Linhai; Qin, Dabin; Dyes and Pigments; vol. 171; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 4887-80-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4887-80-3 as follows.

5 g of methoxybenzimidazole (44.5 mg, 0.3 mmol), NaHCO3 (12.6 mg, 50 mol%), NFSI (142 mg, 1.5 equiv.) Were added to 2.0 mL of acetonitrile and the reaction was stopped for 12 h at 70 C , Column chromatography (silica gel column; eluent: petroleum ether / ethyl acetate = 25/2) to give 2 g of sulfonylated 5-methoxybenzimidazole. The product was a white solid in 67% yield

According to the analysis of related databases, 4887-80-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nanchang University; Guo Shengmei; Jie Kun; Cai Hu; (12 pag.)CN107501194; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 4887-80-3

To a solution of NaH (972 mg, 40.5 mmol) in DMF (20 mL) was added 5- methoxy-lH-benzo[d] imidazole (2.0 g, 13.5 mmol) at 27C. After stirring for 5 minutes, Mel (2.3 g, 16.2 mmol) was added and the resulting mixture was stirred for 16 h. The mixture was then diluted with water (100 mL) and extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with brine (30 mL), dried over Na2S04 and concentrated to give the crude product (1.2 g, 54.5%) as a grown solid. This crude was used in next step without further purification. LCMS (m/z): 163.1 (M+l).

The synthetic route of 4887-80-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; BORIACK-SJODIN, Paula, Ann; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100730; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 4887-80-3, These common heterocyclic compound, 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 92; 4-(lH-Benzoimidazol-5-yloxy)-N-(4-bromo-phenyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4- ylamino)-benzamide; Example 92A; lH-Benzoimidazol-5-ol; [0458] A solution of 5-methoxybenzimidazole (500 mg, 3.374 mmol) in 48% hydrobromic acid (10 mL) was refluxed for 2 hours. The reaction was cooled to room temperature, the solvent removed by rotary evaporation under vacuum, and the residue azeotroped with toluene (50 mL) to provide the title compound as a tan solid (701 mg, 96%).

The synthetic route of 4887-80-3 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 4887-80-3,Some common heterocyclic compound, 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Methoxybenzimidazole (0.50 g, 3.37 mmol) was dissolved in acetonitrile (5 mL), potassium hydroxide (0.39 g, 6.95 mmol) was added, and the mixture was refluxed for 30 min. 2-(Bromomethyl)naphthalene (0.76 g, 3.44 mmol) was added, and the mixture was refluxed overnight.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methoxy-1H-benzo[d]imidazole, its application will become more common.

Reference:
Article; Shelton, Kerri L.; DeBord, Michael A.; Wagers, Patrick O.; Southerland, Marie R.; Williams, Travis M.; Robishaw, Nikki K.; Shriver, Leah P.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Bioorganic and Medicinal Chemistry; vol. 25; 1; (2017); p. 421 – 439;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4887-80-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of NaH (972 mg, 40.5 mmol) in DMF (20 mL) was added 5- methoxy-lH-benzo[d] imidazole (2.0 g, 13.5 mmol) at 27C. After stirring for 5 minutes, Mel (2.3 g, 16.2 mmol) was added and the resulting mixture was stirred for 16 h. The mixture was then diluted with water (100 mL) and extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with brine (30 mL), dried over Na2S04 and concentrated to give the crude product (1.2 g, 54.5%) as a grown solid. This crude was used in next step without further purification. LCMS (m/z): 163.1 (M+l).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; BORIACK-SJODIN, Paula, Ann; MUNCHHOF, Michael, John; JIN, Lei; WO2014/100730; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4887-80-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: PhI(OAc)2 (0.5 mmol) was added to a mixture of 1H-benzimidazole(1a; 0.5 mmol), isochroman (2a; 2.0 mmol), and DCE (2.0mL) in a Schlenk tube at r.t. The mixture was stirred at 80 C for6 h then cooled. H2O (10 mL) was added, and the mixture wasextracted with CH2Cl2 (3 ¡Á 10 mL). The combined organic layerwas dried (Na2SO4) and concentrated under reduced pressure.The residues were purified by flash column chromatography(silica gel, hexane-EtOAc) to give a colorless oil; yield: 115 mg(92%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sun, Bin; Yan, Zhiyang; Jin, Can; Su, Weike; Synlett; vol. 29; 18; (2018); p. 2432 – 2436;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 4887-80-3

General procedure: An excess of 5-substituted benzoimidazoles 4a-d (1.5 equiv.) were dissolved in 8 mL of anhydrous acetonitrile and 1.7 equiv. NaH 95% were added portionwise under stirring in a Schlenk tube at room temperature, applying mechanical vacuum until complete evolution of hydrogen gas. After 15 minutes, 1 g (7.14 mmol) of the 4-hydroxy-2-cyclopentenone acetate (¡À)-1 was dissolved in the minimum amount of anhydrous acetonitrile and added to the solution under stirring. The reactions are left under stirring at room temperature overnight. The reactions were quenched with ice mixed with NaCl/NH4Cl 1:3 and the water phase extracted with DCM. The organic phases were dried over Na2SO4 and, upon evaporation of the solvent, the residues were submitted to chromatographic separation to isolate the purified products 5/6a-d

Statistics shows that 4887-80-3 is playing an increasingly important role. we look forward to future research findings about 5-Methoxy-1H-benzo[d]imidazole.

Reference:
Article; Hameed, Karzan Khaleel; Dezaye, Ahmed Anwar; Hussain, Faiq Hamasaid; Basile, Teresa; Memeo, Misal Giuseppe; Quadrelli, Paolo; Arkivoc; vol. 2018; 7; (2018); p. 201 – 213;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem