Category: 4857-06-1

In 2019,Organic & Biomolecular Chemistry included an article by Wang, Xin; Li, Changhao; Zhang, Yixiao; Zhang, Bing; Sun, Kai. Electric Literature of C7H5ClN2. The article was titled 《Direct methyl C(sp3)-H azolation of thioanisoles via oxidative radical coupling》. The information in the text is summarized as follows:

A method for metal-free, 1,3-dibromo-5,5-dimethylhydantoin mediated Me C(sp3)-H bond azolation of thioanisoles RC6H4SCH3 (R = H, 2-H3CO, 3-Cl, 4-F, etc.) has been developed, affording a facile route for the construction of nitrogen-functionalized thioanisoles RC6H4SCH2R1 (R1 = 2-chloro-1H-1,3-benzodiazol-1-yl, 1H-1,2,3-benzotriazol-1-yl, 5-phenyl-1H-1,2,3,4-tetrazol-1-yl, etc.), possibly via a nitrogen-centered radical process. This reaction represents an important addition to the limited number of existing methods for the Me C(sp3)-H bond functionalization of thioanisoles, and may find practical application in the synthesis of nitrogen-alkylated azoles. After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Electric Literature of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Electric Literature of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Chemistry – A European Journal included an article by Werr, Marco; Kaifer, Elisabeth; Wadepohl, Hubert; Himmel, Hans-Joerg. Name: 2-Chloro-1H-benzo[d]imidazole. The article was titled 《Tuneable Redox Chemistry and Electrochromism of Persistent Symmetric and Asymmetric Azine Radical Cations》. The information in the text is summarized as follows:

Mol. organic radicals have been intensively studied in the last decades, due to their interesting optical, magnetic and redox properties. Here we report the synthesis and characterization of persistent organic radicals from one-electron oxidation of redox-active azines (RAAs), composed of two guanidinyl or related groups. By connecting two different groups together, asym. compounds result. In this way a series of compounds with varying redox potential is obtained that could be oxidized reversibly to the mono- and the dicationic charge states. The accessible redox states were fully determined by chem. redox reactions. The standard Gibbs free energy change for disproportionation of the radical monocation into the dication and the neutral mol. in solution, estimated from cyclovoltammetric measurements, varies between 43 and 71 kJ mol-1. While the neutral RAAs absorb predominately UV light, the radical monocations display strong absorptions covering almost the entire visible region and extending for some compounds into the NIR region. A detailed anal. of this highly reversible electrochromism is presented, and the fast switching characteristics are demonstrated in an electrochromic test device. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Name: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Name: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Chemistry – A European Journal included an article by Wang, Haixia; Yu, Lulu; Xie, Mingsheng; Wu, Jiang; Qu, Guirong; Ding, Kuiling; Guo, Haiming. Name: 2-Chloro-1H-benzo[d]imidazole. The article was titled 《Regio- and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N-Heteroaromatics》. The information in the text is summarized as follows:

Palladium-catalyzed regio- and enantioselective allylic amination of aliphatic Morita-Baylis-Hillman (MBH) adducts with N-heteroaromatic nucleophiles (e.g., benzimidazole, 4,5-diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal-based diphosphine (SKP) ligand, and afforded a range of chiral, branched N-allyl products with high selectivity. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Name: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Name: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Graml, Andreas; Ghosh, Indrajit; Koenig, Burkhard published 《Synthesis of Arylated Nucleobases by Visible Light Photoredox Catalysis》.Journal of Organic Chemistry published the findings.Safety of 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:

Arylated nucleobases, e.g., I, were synthesized by visible light photocatalysis using rhodamine 6G as photoredox catalyst and N,N-diisopropylethylamine as sacrificial electron donor. The high redox potential of this catalyst system is achieved by a consecutive photoinduced electron transfer process (conPET) and allows the room temperature conversion of brominated and chlorinated nucleobases or nucleobase precursors as starting materials. In contrast to many transition-metal-based syntheses, a direct C-H arylation of nitrogen-containing halogenated heterocycles is possible without protection of the N-H groups. The method provides a simple, metal-free alternative for the synthesis of biol. interesting arylated heterocycles under mild conditions. In addition to this study using 2-Chloro-1H-benzo[d]imidazole, there are many other studies that have used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Safety of 2-Chloro-1H-benzo[d]imidazole) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Safety of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis》 was written by Devine, William G.; Diaz-Gonzalez, Rosario; Ceballos-Perez, Gloria; Rojas, Domingo; Satoh, Takashi; Tear, Westley; Ranade, Ranae M.; Barros-Alvarez, Ximena; Hol, Wim G. J.; Buckner, Frederick S.; Navarro, Miguel; Pollastri, Michael P.. Recommanded Product: 2-Chloro-1H-benzo[d]imidazoleThis research focused ontrypanosomiasis trypanosomicide Trypanosoma; crystal structure; Trypanosoma brucei; medicinal chemistry; methionyl-tRNA synthetase. The article conveys some information:

Human African Trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. NEU-1053 I has recently been identified from a high throughput screen of >42,000 compounds as a highly potent and fast acting trypanocidal agent capable of curing a blood stream infection of T. brucei in mice. The authors have designed a library of analogs to probe the SAR and improve the predicted CNS exposure of NEU-1053. The authors report the activity of these inhibitors of Trypanosoma brucei, the efficacy of NEU-1053 in a murine CNS model of infection, and identification of the target of NEU-1053 via x-ray crystallog. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C7H5ClN2In 2022 ,《Cross dehydrogenation coupling reaction of purine derivatives with thioethers》 appeared in Organic & Biomolecular Chemistry. The author of the article were Li, Xinjie; Qi, Peng; Du, Hongguang. The article conveys some information:

A metal-free cross-dehydrogenation coupling method was established to synthesize N9 alkylated purine derivatives Using PhI(OAc)2 as the oxidant, versatile thioethers were successfully employed as alkylation reagents. Under the optimized conditions, a variety of alkylated purine derivatives and other aromatic N-heterocycles were obtained in moderate to good yields. The regioselectivity of this protocol which involves the reaction of unsym. thioethers with purine derivatives was also studied. In addition to this study using 2-Chloro-1H-benzo[d]imidazole, there are many other studies that have used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Martynova, Ekaterina A.; Scattolin, Thomas; Cavarzerani, Enrico; Peng, Min; Van Hecke, Kristof; Rizzolio, Flavio; Nolan, Steven P. published an article in Dalton Transactions. The title of the article was 《A simple synthetic entryway into new families of NHC-gold-amido complexes and their in vitro antitumor activity》.Recommanded Product: 4857-06-1 The author mentioned the following in the article:

A simple synthetic pathway to Au-NHC amido complexes is described. Syntheses and isolation of [Au(NHC)(NR1R2)] complexes, bearing various NHC ligands and NH-containing heterocycles under mild conditions are reported. The in vitro anticancer activity of these gold-complexes was investigated on three human cancer cell lines. A number of these show comparable or even better antiproliferative activity than cisplatin. Noteworthy is the non-toxicity of most of the complexes on normal cells. In the experimental materials used by the author, we found 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Wu, Wen-Long; Wen, Ze-Yu; Qian, Jing-Jing; Zou, Jing-Pei; Liu, Shan-Ming; Yang, Shun; Qin, Tian; Yang, Qun; Liu, Yu-Han; Liu, Wei-Wei; Wang, Jing; Shi, Li-Ying; Shi, Da-Hua published an article in Journal of Molecular Structure. The title of the article was 《Design, synthesis, characterization and evaluation of 1,3,5-triazine-benzimidazole hybrids as multifunctional acetylcholinesterases inhibitors》.SDS of cas: 4857-06-1 The author mentioned the following in the article:

A series of triazine-benzimidazole hybrids I [R = NEt2, NPr2, N(Bn)Et, etc.; n = 0, 1] were designed and synthesized and evaluated as multi-target agents for the treatment of Alzheimer’s disease. Compounds I were designed, synthesized and identified by NMR, IR, HRMS and single-crystal X-ray diffraction studies. The compound I [R = N(n-Bu)2, n = 0] had the crystal system of orthorhombic and the space group of P212121. The cholinesterase inhibitory activity of synthesized compounds I was measured using colorimetric Ellman’s method. Most 1,3,5-triazine-benzimidazole hybrids I showed potent acetylcholinesterase-inhibition activities and weak butyrylcholinesterase inhibitory activities. Compound I [R = N(Cy)Me, n = 1] possessed the best acetylcholinesterase inhibitory activity with the IC50 of 0.044μM, which was better than donepezil (0.052μM). Mol. docking and mol. dynamics simulations demonstrated that there was a stable interaction between compound I [R = N(Cy)Me, n = 1] and acetylcholinesterase. Simultaneously, experiments have also proved that compound I [R = N(Cy)Me, n = 1] has good metal chelating properties. ADMET in silico prediction results suggest the compound can pass through the blood-brain barrier well and have good drug similarity. So, compound I [R = N(Cy)Me, n = 1] could be a multi-target agent for the treatment of Alzheimer’s disease.2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1SDS of cas: 4857-06-1) was used in this study.

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.SDS of cas: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Ying-Ying; Liu, Man; Dong, Lin published an article in 2021. The article was titled 《Rh(III)-Catalyzed multi-site-selective C-H bond functionalization: condition-controlled synthesis of diverse fused polycyclic benzimidazole derivatives》, and you may find the article in Organic Chemistry Frontiers.Synthetic Route of C7H5ClN2 The information in the text is summarized as follows:

Novel fused polycyclic- and multi-substituted 2-oxyl naphthalene benzimidazole derivatives were selectively synthesized via Rh(III)-catalyzed tandem C-H activation/cyclization. The efficient strategy for the construction of diverse annulation products was precisely controlled by changing the reaction conditions. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Synthetic Route of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Synthetic Route of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fan, Guang-Gao; Jiang, Bo-Wen; Sang, Wei; Cheng, Hua; Zhang, Rui; Yu, Bao-Yi; Yuan, Ye; Chen, Cheng; Verpoort, Francis published an article in 2021. The article was titled 《Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C-N Coupling Protocol》, and you may find the article in Journal of Organic Chemistry.Computed Properties of C7H5ClN2 The information in the text is summarized as follows:

Herein, a metal-free and solvent-free protocol was developed for the C-N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallog. anal. of 1-Methyl-N-phenyl-1H-benzo[d]imidazol-2-amine hydrochloride played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug mols., which demonstrated its practical value for further applications. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem