Category: 4760-35-4

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, Computed Properties of 4760-35-4, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Related Products of imidazoles-derivatives, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Leigh, Vivienne published the artcileSynthesis of pincer-type N-heterocyclic carbene palladium complexes with a hemilabile ligand and their application in cross-coupling catalysis, Category: imidazoles-derivatives, the publication is Journal of Organometallic Chemistry (2014), 33-39, database is CAplus.

Benzimidazolium salts containing both a neutral imine and a masked carboxylate functional group for potential metal chelation were prepared Palladation of the ester-protected ligand afforded a N,C-bidentate carbene complex I [X = Cl, Br]. Subsequent ester hydrolysis preserved the bidentate coordination mode and yielded complex II [X = Cl, CF₃CO₂] with a pending COOH group exclusively. However, when ester deprotection was carried out prior to metalation, the N,C,O-tridentate pincer-type coordinated palladium complex III was obtained. Proton-abstraction of the dangling COOH group in the bidentate ligand of complex II by treatment with a base led to the formation of the N,C,O-tridentate coordinated Pd system III, and inversely, exposure of the tridentate bound Pd complex III with acid afforded the N,C-bidentate ligand coordination mode in complex II, demonstrating hemilability of the oxygen donor site in the pincer ligand. All three palladium(II) complexes I, II and III were evaluated in cross-coupling catalysis and revealed distinct activity differences that are dependent on the type of coupling. These differences suggest that judicious choice of donor groups in pincer-type complexes is a viable strategy for catalyst optimization.

Journal of Organometallic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem