Category: 4760-35-4

Thiel, W. published the artcileDithiocarboxylic acids, dithiocarboxylic esters, or thiocarboxylic amides by reaction of methylene-active chloromethyl compounds with sulfur, SDS of cas: 4760-35-4, the publication is Journal fuer Praktische Chemie (Leipzig) (1989), 331(2), 243-62, database is CAplus.

With a mixture of S and amine in DMF at room temperature halomethyl compounds can be oxidized to give thiocarboxylic acids and their derivatives The reaction was studied in detail especially with chloroacetic derivatives or chloromethyl heterocycles formally derived from chloroacetic acid. The resulting thiooxalic acid derivatives represent activated acids and very useful C₂-synthons, especially for the synthesis of heterocycles. Oxidation in the presence of Et₃N leads to dithiocarboxylates which can be alkylated to dithioesters in high yields. As a rule, with different primary and secondary amines instead of tertiary amines these dithiocarboxylates or dithiocarboxylic esters can be transformed already at low temperatures to thioamides.

Journal fuer Praktische Chemie (Leipzig) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C16H12O, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Podder, Nirmalya published the artcileAerobic oxidation of 2-aminophenol catalysed by a series of mononuclear copper(II) complexes: phenoxazinone synthase-like activity and mechanistic study, Synthetic Route of 4760-35-4, the publication is New Journal of Chemistry, database is CAplus.

Three mononuclear copper(II) complexes of types [Cu(L¹)(Cl)₂]·MeOH (1·MeOH), [Cu(L²)(Cl)₂]·H₂O (2·H₂O) and [Cu(L³)(Cl)₂] (3) have been synthesized from three reduced Schiff base tridentate N₃ ligands, namely N-(pyridin-2-ylmethyl)quinolin-8-amine ([H₂]L¹), N-(1-methylbenzimidazol-2-ylmethyl)quinolin-8-amine ([H₂]L²), and N-(1-methylimidazol-2-ylmethyl)quinolin-8-amine ([H₂]L³), resp., having variable donor moieties. During metalation all three reduced Schiff base ligands undergo oxidative dehydrogenation in situ under aerobic conditions to yield the corresponding Schiff base ligated mononuclear copper(II) complexes. All complexes have been characterized using various spectroscopic techniques such as IR, HRMS-ESI, UV-vis, and EPR. Structural characterization of each complex by single crystal x-ray diffraction reveals that the coordination environment around the copper ion is distorted square pyramidal. The three complexes effectively catalyze the aerial oxidation of 2-aminophenol (H₂AP) to 2-amino-phenoxazine-3-one (APX), thus mimicking the catalytic function of the enzyme phenoxazinone synthase. Kinetic studies have been done to arrive at the following catalytic efficiency order: 3 â‰?2·H₂O > 1·MeOH. The observed trend can be explained by considering the structure-function relation of the catalytic activity. Intramol. charge distribution (valence tautomerism) within a complex-substrate adduct leads to the generation of a “Cu^I-(substrate radical)” tautomer. This phenomenon has been established by EPR spectroscopy, particularly using 2-anilino-4,6-di-tert-butylphenol (H₂AP^Ph,t-Bu, a structural analog of H₂AP) as a substrate. Such a “Cu^I-(substrate radical)” species is believed to promote dioxygen activation. The effects of temperature and pH on the reaction rates have been studied. Activation parameters (E_a, ΔH^{â€?/sup>, and ΔSâ€?/sup>) have been evaluated from temperature-dependent kinetic measurements. A plausible reaction pathway has been proposed on the basis of stoichiometry determination, spectroscopic data and kinetic anal.}

New Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileDesign and Synthesis of Benzimidazole-Linked meta-Substituted Benzylidenes/Benzyls as Biologically Significant New Chemical Entities, Computed Properties of 4760-35-4, the publication is Synthetic Communications (2013), 43(14), 1882-1895, database is CAplus.

Meta-Linked thiazolidinedione (TZD)- and di-Et malonate (DEM)-based benzylidenes and Me acetoacetate (MAA)-based benzyl moieties linked to the 2-position of N-Me benzimidazole were synthesized. TZD- and DEM-based compounds were synthesized by condensation of 2,4-thiazolidinedone and DEM resp. with the corresponding 3-substituted benzaldehyde, whereas MAA-based compounds were obtained by halogen displacement with the corresponding 3-substituted phenol. These new chem. entities were designed to provide a balanced agonism at the peroxisome proliferator activated receptor alpha/gamma in the management of type 2 diabetes: a move from glitazones to selective PPAR modulators.

Synthetic Communications published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C4H3Cl2N3, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Goswami, Shyamaprosad published the artcileA FRET-based rhodamine-benzimidazole conjugate as a Cu²⁺-selective colorimetric and ratiometric fluorescence probe that functions as a cytoplasm marker, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is RSC Advances (2014), 4(12), 6300-6305, database is CAplus.

On the basis of fluorescence resonance energy transfer (FRET) from benzimidazole to a rhodamine moiety, a rhodamine-benzimidazole conjugate (RBC) ratiometric fluorescent probe has been designed and synthesized. The RBC selectively binds to Cu²⁺, showing visually observable changes in absorption and emission behavior, and demonstrates an effective intracellular Cu²⁺ imaging ability, allowing it to function as a cytoplasm marker.

RSC Advances published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gong, Yanmei published the artcileHigh performance benzoimidazolyl-based aminophenolate zinc complexes for isoselective polymerization of rac-lactide, Formula: C9H9ClN2, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(68), 10112-10115, database is CAplus and MEDLINE.

Zinc complexes supported by achiral benzoimidazolyl-based aminophenolate ligands exhibit high catalytic activities and excellent isoselectivities toward the ring-opening polymerization of rac-lactide under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Formula: C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mitra, Mainak published the artcileEvidence that steric factors modulate reactivity of tautomeric iron-oxo species in stereospecific alkane C-H hydroxylation, HPLC of Formula: 4760-35-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(12), 1408-1410, database is CAplus and MEDLINE.

A new iron complex mediates stereospecific hydroxylation of alkyl C-H bonds with hydrogen peroxide, exhibiting excellent efficiency. Isotope labeling studies provide evidence that the relative reactivity of tautomerically related oxo-iron species responsible for the C-H hydroxylation reaction is dominated by steric factors.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, HPLC of Formula: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Yali published the artcileHalf-sandwich Iridium(III) Benzimidazole-Appended Imidazolium-Based N-heterocyclic Carbene Complexes and Antitumor Application, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Chemistry – An Asian Journal (2018), 13(23), 3697-3705, database is CAplus and MEDLINE.

A series of half-sandwich iridium(III) benzimidazole-appended imidazolium-based N-heterocyclic carbene (NHC) antitumor complexes [(η⁵-Cp^x)Ir(CN̂)Cl]Cl, where Cp^x is pentamethylcyclopentadienyl (Cp*) or its biphenyl derivative (Cp^xbiph) and CN̂ is a NHC chelating ligand, were successfully synthesized and characterized. The Ir^III complexes showed potential antitumor activity against A549 cells, at most three times more potent than cis-platin under the same conditions. Complexes could bind to BSA by a static quenching mode, catalyzing the change of NADH to NAD⁺ and inducing the production of reactive oxygen species (maximum turnover number, 9.8), which play an important role in regulating cell apoptosis. Confocal microscopy showed that the complexes could specifically target lysosomes in cells with a Pearson’s co-localization coefficient 0.76 and 0.72 after 1 h and 6 h, resp., followed an energy-dependent cellular uptake mechanism and damaged the integrity of lysosomes. At the same time, complexes caused a marked loss of mitochondrial membrane potential.

Chemistry – An Asian Journal published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jianming published the artcileConstruction of the flavones and aurones through regioselective carbonylative annulation of 2-bromophenols and terminal alkynes, Synthetic Route of 4760-35-4, the publication is Tetrahedron Letters (2013), 54(14), 1802-1807, database is CAplus.

The easily available and efficient catalyst containing a benzimidazolium ligand and PdCl₂(PPh₃)₂ demonstrated excellent catalytic activity to construct the flavones and aurones, resp. This reaction can be operated under mild conditions, affording the desired products in moderate to good yields. This protocol was used to prepare the flavones and aurones by a slight modification of amines.

Tetrahedron Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ding, Yangyang published the artcileDesign, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Journal of Chemical Research (2020), 44(5-6), 286-294, database is CAplus.

The vascular endothelial growth factor receptor-2 signaling pathway promotes the formation of new blood vessels, and vascular endothelial growth factor receptor-2 tyrosine kinase exists in both active and inactive conformations. Novel indole-benzimidazole and indole-benzothiazole derivatives joined by different linkers are designed and synthesized as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. All the synthesized compounds were evaluated for their cytotoxicity against four human cancer cell lines (HeLa, HT29, A549, and MDA-MB-435) and human umbilical vein endothelial cell. Meanwhile, the inhibitory activities against vascular endothelial growth factor receptor-2 are estimated in vitro and the binding interactions with dual conformations of vascular endothelial growth factor receptor-2 tyrosine kinase are evaluated by mol. docking. Compounds 5a-c and 14 show inhibitory activity against vascular endothelial growth factor receptor-2 tyrosine kinase and promising cytotoxicity, specifically with IC₅₀ values ranging between 0.1 and 1μM, which imply broad-spectrum antitumor activity. These results provide a deep insight into potential structural modifications for developing potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.

Journal of Chemical Research published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xue, Yang published the artcileNovel hypoglycemic compound-synthesis of glycine derivatives and research on the role of PPARs, SDS of cas: 4760-35-4, the publication is Jiefangjun Yaoxue Xuebao (2009), 25(1), 5-10, database is CAplus.

The aim of this paper is to synthesize five novel hypoglycemic glycine-type drugs and research the role of PPARs. The synthesis started with the reaction between 4-hydroxybenzaldehyde and 3-[4-phenoxyphenoxy] propanol, 2-(4-phenoxyphenoxy) ethanol, benzimidazole derivatives The resulting compounds were condensed with proper aldehyde to give Schiff bases. The imine derivatives reacted with 4-methoxyphenyl carbonochloridate, followed by hydrolysis, to give the desired glycine analogs. The target’s role in the activation of PPARs was determined The results showed that the 5 novel compounds were synthesized and characterized by ¹HNMR. Targets show varying degrees of activation of PPARs. The bioassay indicated that five target compounds 6a, 6b, 6c, 6’a, 6’b were capable of activating PPARs. Among them, 6a, 6b, 6c are more effective. They can be good candidates for the therapy of insulin resistance and high blood sugar.

Jiefangjun Yaoxue Xuebao published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7ClN2S, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem