Application of 4589-66-6, These common heterocyclic compound, 4589-66-6, name is (1,2-Dimethyl-1H-benzo[d]imidazol-5-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) (1,2-Dimethyl-1H-benzo[d]imidazol-5-yl)methanol To a suspension of 1,2-Dimethyl-1H-benzo[d]imidazole-5-carboxylic acid (crude, 2.54 g, approx. 9.35 mmol) in MeOH (15.5 ml)/toluene (78 ml) Trimethylsilyldiazomethane (2 M solution in hexane, 7.0 ml, 14 mmol) was added at 0-10 C. The reaction mixture was stirred at it for 1 hour. The reaction mixture was evaporated under reduced pressure. The residue was taken up in DCM, Remaining insoluble solid was filtered off. The filtrate was evaporated again to dryness to afford crude Methyl 1,2-dimethyl-1H-benzo[d]imidazole-5-carboxylate
The synthetic route of 4589-66-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; US2012/35168; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem