Category: 45676-04-8

Electric Literature of 45676-04-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 45676-04-8 as follows.

To a 250 mL three-necked flask, 6.8 g of N-tert-butylimidazole and 9.3 g (molar ratio 1: 1) of chloroform were added to a reactor equipped with a magnetic stirrer, a heating apparatus and a condensing apparatus, and toluene was added as a solvent , 2.5 g of sodium hydride as the catalyst, at 90 C, stirring reaction 12h, separation and purification of N-tert-butyl imidazole. 6.2 g of the above product and 6.2 g (molar ratio 1: 1) of chloromethyltrimethylsilane were added to a reaction vessel equipped with a magnetic stirrer, a heating apparatus and a condensing apparatus, 100 mL of toluene as a solvent, argon gas, 120 C for 24 h, and purified to obtain N-methylsilyl (trimethyl) imidazole type ionic liquid.

According to the analysis of related databases, 45676-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou Normal University; Bai, Ying; Peng, Jiajian; Yang, Xioaling; Zhang, Fengxiang; Li, Jiayun; Xiao, Wenjun; (8 pag.)CN106380487; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 45676-04-8, A common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.2.7) 3-tert-Butyl-1-[(tert-butyl(methyl)phosphinooxy)methyl]imidazolium tosylate 15 In a Schlenk tube with pressure release valve, 1.00 g (3.3 mmol) of tert-butyl(methyl)-(tosylmethyl)phosphine oxide (14) and 0.45 g (3.6 mmol) of N-tert-butylimidazole (1) were stirred in 0.7 ml of toluene at 105 C. for 72 hours. The red-brown, viscous oil was precipitated from 10 ml of hexane in an ultrasound bath.

The synthetic route of 45676-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; US2010/317866; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 45676-04-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 45676-04-8, name is 1-tert-Butylimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

The procedure given for the synthesis of [DPCP-(ImidMe)2]Cl2 was followed. Yield: 92%. mp: 170-173 C. 1H NMR (400 MHz, CDCl3): delta 12.00 (s, 2H, imidazole-NCHN), 8.47 (s, 2H, imidazole-NCHCHN), 8.10 (s, 2H, imidazole-NCHCHN), 7.73 (m, 6H, Ph-H), 7.62 (m, 4H, Ph-H), 1.90 [s, 18H, C(CH3)3] ppm. 13C NMR (100 MHz, CDCl3): delta 159.86, 137.69, 134.90, 131.27, 129.76, 129.03, 128.22, 127.61, 122.01, 119.29, 62.83, 30.35 ppm. 31P (161 MHz, CDCl3): delta 41.89 ppm (s).

The synthetic route of 1-tert-Butylimidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Senkuttuvan; Ramakrishna; Bakthavachalam; Reddy, N. Dastagiri; Journal of Organometallic Chemistry; vol. 723; (2013); p. 72 – 78;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 45676-04-8,Some common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 1-substituted 3-allylimidazolium chloride (2 mmol) was dissolved in 25 mL of dichloromethane and transferred into a Schlenk vessel. Excess Silver(I) oxide (1.5 mmol) was added, and the mixture was stirred for24 h at room temperature under argon atmosphere [19]. Then the unreactedAg2O was filtered through a plug of Celite. The resulting solution was filtered through celite, solvent was evaporated in vaccuo,washed with diethylether (2 mL×2) and dried in vacuo.[RuBr2(PPh3)3] (1 g, 1 mmol) was taken up in 5 mL of dichloromethane and added to a solution of Ag complex in 10 mL of CH2Cl2. The mixture was stirred overnight at room temperature. After filtration in air, the solvent was removed in vacuum to give the product. The final compound is stable in air. Single crystals of the compound 3a were achievedby slow evaporation of a concentrated solution in a mixture of dichloromethane and acetone.

The synthetic route of 45676-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nirmala, Muthukumaran; Murugan, Kaliyappan; Vijayapritha, Subbarayan; Viswanathamurthi, Periasamy; Bertani, Roberta; Malecki, Jan Grzegorz; Inorganica Chimica Acta; vol. 486; (2019); p. 55 – 62;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 45676-04-8, name is 1-tert-Butylimidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H12N2

General procedure: Liquid 1-methylimidazole (a) or 1-phenylimidazole (b) or 1-tert-butylimidazole (c) (1 mol equiv.) was added to a stirring solutionof compound 3 (1 mol equiv.) in 50 mL of CH3CN. The reactionmixture was heated at refluxing temperature for 48 h. Then,the reaction mixturewas reduced in vacuo and the resulting oil wasstirred in diethyl ether. The diethyl ether layer was decanted awayto give ligand 4a, 4b and 4c. The spectral data for these compoundsare consistent with those reported in the literature [25,26,29].

The synthetic route of 45676-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin; Journal of Organometallic Chemistry; vol. 898; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 45676-04-8, The chemical industry reduces the impact on the environment during synthesis 45676-04-8, name is 1-tert-Butylimidazole, I believe this compound will play a more active role in future production and life.

F) 1,1′-Di-tert-butyl-3,3′-methylenediimidazolium diiodide 13 0.008 mol of diiodomethane (2.143 g; 0.64 ml) and 5 ml of tetrahydrofuran are added to 0.016 mol of tertbutylimidazole 2 (2.000 g) in an ACE pressure tube. The reaction mixture is stirred at 80 C. for 3 hours. The precipitated solid is washed repeatedly with a little tetrahydrofuran. The white solid 13 is obtained. Empirical formula: C15H26N4I2 M=516.198 g/mol Yield: 1.444 g (35.0% of theory) Melting point: decomposition at >249 C. 1H (ppm, d6-DMSO, 300.13 MHz): delta=9.55 (s, 2H, NCN); 8.17 (s, 2H, NCCHN); 8.06 (s, 2H, NCHCN); 6.54 (s, 2H, NC2N); 1.61 (s, 18H, C3 group)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-tert-Butylimidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BASF SE; TECHNISCHE UNIVERSITAET DRESDEN; US2009/326237; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 45676-04-8,Some common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

E) 1,1′-Di-tert-butyl-3,3′-methylenedimidazolium dibromide 12 0.008 mol of dibromomethane (1.391 g; 0.56 ml) and 5 ml of tetrahydrofuran are added to 0.016 mol of tertbutylimidazole 2 (2.000 g) in an ACE pressure tube. The reaction mixture is stirred at 80 C. for 20 hours. The solid which precipitates is washed repeatedly with a little tetrahydrofuran. A white solid 12 is obtained. Empirical formula: C15H26N4Br2 M=422.206 g/mol Yield: 1.449 g (42.9% of theory) Melting point: decomposition at >230 C. 1H (ppm, d6-DMSO, 300.13 MHz): delta=9.85 (s, 2H, NCN); 8.21 (s, 2H, NCCHN); 8.17 (s, 2H, NCHCN); 6.67 (s, 2H, NC2N); 1.62 (s, 18H, C3 group)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-tert-Butylimidazole, its application will become more common.

Reference:
Patent; BASF SE; TECHNISCHE UNIVERSITAET DRESDEN; US2009/326237; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 45676-04-8, name is 1-tert-Butylimidazole, A new synthetic method of this compound is introduced below., Product Details of 45676-04-8

THF (200 ml) and 1-tert-butylimidazole (12.42 g, 0.1 mol) were added into a 500 ml reactor containing a stirrer with N2 fully charged. After stirring evenly, the solution was cooled to -45 C. A solution of n-butyl lithium hexane (41.6 ml, 2.4 mol/L) was extracted with a 100 mL syringe and added slowly to the solution above while string. After stirring at -45 C. for 1 hour, the solution was raised to room temperature and kept stirring for 1 hour. Then, the solvent was removed by vacuum, and hexane (100 ml) was added in. 12.08 g (0.098 mol, 92.8%) product was obtained by remove the volatile components in vacuum after dispersion and filtration.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Tianjin University of Science&Technology; Jiang, Tao; Chen, Yanhui; Zhang, Le; Alam, Fakhre; Shao, Huaiqi; Li, Jian; Yan, Bing; (9 pag.)US2019/106366; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 45676-04-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 45676-04-8 as follows.

trans-diiodo(pyridine)(1-benzyl-3-tert-butylimidazol-2-ylidene)platinum(II)Step 1: 1-benzyl-3-tert-butylimidazolium chlorideA solution of 1-tert-butylimidazole, which was obtained according to A. J. Arduengo (2001) U.S. Pat. No. 6,177,575, (0.31 g; 2.5 mmol) in benzyl chloride (0.3 ml; 2.5 mmol) is stirred at room temperature for 48 h. The volatiles are then evaporated under vacuum. The residue obtained is triturated in ethyl ether and then filtered, thus making it possible to obtain 0.54 g (87%) of 1-benzyl-3-tert-butylimidazolium chloride whose characteristics are the following:1H NMR (300 MHz, CDCl3) delta ppm: 1.73 (s, 9H), 5.71 (s, 2H), 7.15 (m, 1H), 7.25 (m, 1H), 7.38 (m, 3H), 7.52 (m, 2H), 11.41 (s, 1H).

According to the analysis of related databases, 45676-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANOFI-AVENTIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; US2011/172199; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 45676-04-8,Some common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This ligand was prepared according to a literature method [15] with slight modifications. A mixture of 2,6-dichloropyridine (1.5g, 10mmol) and 1-tert-butylimidazole (5.0g, 40mmol) was heated in an autoclave at 150C for 3 days. Upon cooling, the reaction mixture was dissolved in MeOH (5mL), followed by addition of a large amount of diethyl ether. After filtration, the precipitate was washed with acetone (20mL) and dried to give 2,6-bis(3-tert-butylimidazolium-1-yl)pyridine dichloride as an off-white solid (2.7g, 68%). 1H NMR (CD3CN): delta 10.37 (brs, 2H, NCHN), 8.97 (brs, 2H, imid), 8.58 (t, J=8.1Hz, 1H, 4-py), 8.46 (d, J=8.0Hz, 2H, 3,5-py), 8.36 (brs, 2H, imid), 1.72 (s, 18H, tBu). ESI-MS (m/z): 360.4 [M-Cl]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-tert-Butylimidazole, its application will become more common.

Reference:
Article; Nakamura, Takuo; Ogushi, Shinji; Arikawa, Yasuhiro; Umakoshi, Keisuke; Journal of Organometallic Chemistry; vol. 803; (2016); p. 67 – 72;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem