Category: 45533-87-7

Ono, Takeshi published the artcileThe synthesis of ophidin, Name: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie (1956), 77-81, database is CAplus.

cf. f. Biochem. (Tokyo) 36, 265(1942). Ophidin (I), a dipeptide from snake muscle, was proven by synthesis to be 2-methyl-Nα – (β-alanyl)-L-histidine (II). D-fructose, AcH, NH₃, and CuCO₃ gave the Cu salt of 2-methyl-4-(hydroxymethyl)imidazole, which was freed from Cu by H₂S and isolated in 60% yield as the picrate, m. 187-90°, giving an HCl salt (III), m. 138-40°. III and SOCl₂ gave 2-methyl-4-(chloromethyl)imidazole, m. 125°, condensed with AcNHCH(CO₂Et), to give Et α-acetamido-α-carbethoxy-β-[4-(2-methylimidazolyl)]propionate (IV), m. 120°, in 50% yield. IV refluxed with concentrated HCl gave DL-2-methylhistidine (V) (isolated as the Hg salt and freed with H₂S), m. 231°; di-HCl salt (VI), m. 247°; dipicrate, m. 165°. V gave pos. ninhydrin and diazo reactions. The Ac derivative of V was resolved with acylase I to give L-2-methylhistidine (VII), m. 235°, [α]¹⁵_D -25.00° (1% aqueous solution). VI and β-phthalimido-propionyl chloride gave 50% phthalimide of DL-II, decompose 240°, which with N₂H₄ gave DL-II, m. 249°, in 72% yield. By similar reactions VII gave II, m. 246-8°, [α]¹²_D 36.6° (1% aqueous solution); picrolonate, m. 232° (undepressed by I picrolonate).

Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurdziel, K. published the artcileCoordination properties of 4(5)-hydroxymethylimidazole and 4(5)-hydroxymethyl-5(4)-methylimidazole towards cobalt(II) ions, Safety of (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Journal of Coordination Chemistry (2007), 60(8), 877-889, database is CAplus.

Two new complexes of imidazole alcs., 4-hydroxymethylimidazole (4-CH₂OHim) and 4-hydroxymethyl-5-methylimidazole (4-CH₂OH-5-CH₃i.m.), with Co(II), [CoL₂(H₂O)₂](NO₃)₂ were obtained. These compounds were characterized through single x-ray diffraction studies, spectroscopic (IR, far-IR, UV-visible-NIR) and magnetic measurements. The hydroxymethylimidazole ligands are bidentate, coordinating the heterocyclic ring through pyridine-like N atoms and the O atom of the hydroxymethyl group (chromophore CoN₂O₄). The Co(II) coordination polyhedra are distorted octahedrons, with the equatorial plane defined by the 4-CH₂OHim (or 4-CH2OH-5-CH₃i.m.) bidentate ligands and two H₂O mols. occupying axial (trans) positions. Formation of successive Co(II) complexes with 4-CH₂OH-5-CH₃i.m. in aqueous solution was followed quant. by potentiometry.

Journal of Coordination Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Safety of (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem