Category: 4532-96-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4532-96-1, name is 1-Isopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Isopropyl-1H-imidazole

(a) 1-Isopropyl-2-(4-methoxybenzenesulphonyl) imidazole Into 20 ml of acetonitrile was introduced 0.1 mol of 1-isopropylimidazole. After that 0.1 mol of 4-methoxybenzenesulphonyl chloride in 20 ml of acetonitrile was added drop-by-drop. The addition took one hour and the temperature increased to 35 C. After one hour stirring at room-temperature 0.11 mol of triethylamine was added to the reaction medium and stirring was maintained for 20 hours. The precipitate which formed was suction-filtered the filtrate was evaporated to dryness and the residue was dissolved in ethyl acetate. After washing with neutral water, the extract was dried and isolated to give 18.3 g of a brownish oil which was purified on a silica column. The elution with ethyl acetate provided 4.5 g of a brownish oil which solidified. In this manner, 1-isopropyl-2-(4-methoxybenzenesulphonyl) imidazole was obtained in a yield of 16%. Purity: 99.9% (high pressure liquid chromatography) M.P.: 84-86 C. (ethyl acetate/n-hexane 1/2) Using the same procedure as that described above 1-benzyl-2-(4-methoxybenzenesulphonyl) imidazole was obtained in the form of a white beige solid. M.P.: 74.5 C. (ethyl acetate/n-hexane 1/2)

The synthetic route of 4532-96-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sanofi; US4994474; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 4532-96-1, The chemical industry reduces the impact on the environment during synthesis 4532-96-1, name is 1-Isopropyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

A) 1,1′-Diisopropyl-3,3′-methylenediimidazolium dibromide 8 0.009 mol of dibromomethane (1.564 g; 0.63 ml) and 5 ml of tetrahydrofuran are added to 0.018 mol of isopropylimidazole 1 (2.000 g) in an ACE pressure tube. The reaction mixture is stirred at 80 C. for 20 hours. The solid which precipitates is washed repeatedly with a little tetrahydrofuran. A white solid 8 is obtained. Empirical formula: C13H22N4Br2 M=394.154 g/mol Yield: 1.032 g (36.7% of theory) Melting point: decomposition at >172 C. 1H (ppm, d6-DMSO, 300.13 MHz): delta=9.68 (s, 2H, NCN); 8.11 (t, 2H, J=1.75 Hz, NCCHN); 8.04 (t, 2H, J=1.75 Hz, NCHCN); 6.66 (s, 2H, NC2N); 4.70 (sept, 2H, J=6.6 Hz (CH3)2CN); 1.50 (d, 12H, J=6.6 Hz, C3 group)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Isopropyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BASF SE; TECHNISCHE UNIVERSITAET DRESDEN; US2009/326237; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem