Reference of 4316-42-1, A common heterocyclic compound, 4316-42-1, name is 1-Butyl-1H-imidazole, molecular formula is C7H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-butyl imidazole put 1.82 mmol (0.24 mL) and 2.18 mmol NH4I (317 mg) and trimethyl ortho formate 9.1mmol (1 mL) in a Schlenk reaction tube and reflux under air or N2. Confirming that the protonated imidazole disappears then removed trimethyl ortho formate remaining under vacuum, and then, a small amount of the protonated imidazole deprotonation was passed through a basic alumina dissolved in ethyl acetate. After having passed through this solution, putting them in a vacuum and the product was confirmed by NMR. Yield: 98%
The synthetic route of 4316-42-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pusan National UniversityIndustry-AcademicCooperation Foundation; Park, Jin Gyun; Kim, Do Chung; Oh, Gyung Hwan; (23 pag.)KR2015/79403; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem