Category: 4238-71-5

Related Products of 4238-71-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4238-71-5 name is 1-Benzyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a mixture of acetylene 2 (127 mg, 1 mmol) and S (32 mg, 1 mmol) was added 1-methylimidazole (1a; 82 mg, 1 mmol). The mixture was stirred at 20-25 C for 24 h. Column chromatography afforded thione 3a (132 mg, 67%), 4.3.7 (Z)-3-(3-Benzyl-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)-3-phenyl-2-propenenitrile (3e) Analogously, from acetylene 2 (64.0 mg, 0.5 mmol), S (16.0 mg, 0.5 mmol), and 1-benzylimidazole (1e; 79.0 mg, 0.5 mmol) in MeCN (1 mL) (20-25 C, 24 h) thione 3e (27 mg, 96%) was obtained as a light-yellow microcrystalline powder, mp 129-131 C (washed with ether). Initial imidazole 1e was recovered (65 mg, conversion was 18%). 1H NMR (400.13 MHz, CDCl3): delta=7.50-7.30 [m, 10H, Ho,m,p from C(6)-Ph and Ph from N-Bn], 6.74 (s, 2H, 4-H, 5-H), 6.06 (s, 1H, 7-H), 5.27 (s, 2H, CH2 from N-Bn) ppm. 13C NMR (100.62 MHz, CDCl3): delta=164.7 (C-2), 154.1 (C-6), 135.2 (Ci, Ph from N-Bn), 132.4 [Ci from C(6)-Ph], 131.8 [Cp from C(6)-Ph], 129.1 [Cm from C(6)-Ph], 128.9 (Cm, Ph from N-Bn), 128.2 (Cp, Ph from N-Bn), 128.1 (Co, Ph from N-Bn), 126.7 [Co from C(6)-Ph], 118.3 (C-4), 117.1 (C-5), 114.5 (CN), 97.2 (C-7), 51.3 (CH2 from N-Bn) ppm. IR (KBr): 2221 (CN), 1621 (C=C), 1398 (C=S) cm-1. Anal. Calcd for C19H15N3S (317.41): C, 71.90; H, 4.76; N, 13.24; S, 10.10. Found: C, 71.67; H, 4.85; N, 12.92; S, 9.84.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Benzyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Article; Belyaeva, Kseniya V.; Andriyankova, Ludmila V.; Nikitina, Lina P.; Mal’Kina, Anastasiya G.; Afonin, Andrei V.; Ushakov, Igor A.; Bagryanskaya, Irina Yu.; Trofimov, Boris A.; Tetrahedron; vol. 70; 5; (2014); p. 1091 – 1098;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4238-71-5 as follows. Quality Control of 1-Benzyl-1H-imidazole

General procedure: Yield: 82%. Yellow oil. 1H NMR (400HMz, CDCl3, TMS) delta 10.61 (s, 1H), 7.49-7.47 (m, 2H), 7.43(s, 1H), 7.39(s, 1H), 7.34-7.32 (m, 3H), 5.59 (s, 2H), 4.27 (t, J = 6.0 Hz, 2H), 1.90-1.83 (m, 2H), 1.38-1.29 (m, 2H), 0.91(t, J = 6.0 Hz, 3H). 13C NMR (100HMz, CDCl3; TMS) delta 136.12, 134.49, 128.94, 128.68, 128.30, 122.78, 122.50, 51.79, 48.65, 31.23, 18.76, 13.24.

According to the analysis of related databases, 4238-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wu, Shi; Wang, Binshen; Zhang, Yongya; Elageed, Elnazeer H.M.; Wu, Haihong; Gao, Guohua; Journal of Molecular Catalysis A: Chemical; vol. 418-419; (2016); p. 1 – 8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 4238-71-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4238-71-5, name is 1-Benzyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a cooled (-500C) suspension of 1 -benzyl- lH-imidazole (1,58 g, 10.0 mmol) in anhydrous diethyl ether (50 mL) under nitrogen was added H-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at – 500C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL), acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of this precipitate gave a white solid which was suspended in methanol, treated with IiV HCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded the HCl salt of Cap- 136 as a white solid (817 mg, 40%). 1H NMR (300 MHz, DMSO-d6) delta 7.94 (d, J= 1.5 Hz, IH), 7.71 (d, J- 1.5 Hz, IH), 7.50-7.31 (m, 5H), 5.77 (s, 2H); Rt = 0.51 min (Cond. MS-W5); 95% homogenity index; LRMS: Anal. CaIc. for [M+H]+ C11H12N2O2: 203.08; found: 203.11.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LOPEZ, Omar D.; CHEN, Qi; BELEMA, Makonen; WO2010/138368; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 4238-71-5, The chemical industry reduces the impact on the environment during synthesis 4238-71-5, name is 1-Benzyl-1H-imidazole, I believe this compound will play a more active role in future production and life.

1-Benzyl-2-iodo-imidazol (Compound 50, Scheme 19) was prepared by adding n-BuLi, (2.5 M in Hexane, 15.2 ml, 39 mmol) to a stirred solution of diisopropylamine (5.8 ml, 41.1 mmol) in THF (30 ml) at 0 C. After 30 minutes of stirring, the temperature was lowered to -78 C. and Compound 49 (1-benzyl-imidazol, 5 grams, 31.6 mmol) in THF (20 ml) was added thereto. The temperature was then increased to 0 C. and the reaction mixture was stirred at the same temperature for 30 minutes, then cooled down to -78 C. and finally iodine (8.8 grams, 34.8 mmol) in THF (20 ml) was added to the reaction mixture. The reaction mixture was stirred at room temperature for 2 hours and was quenched with aqueous NH4Cl, extracted with ethyl acetate, and the organic layer was washed with brine, dried over Na2SO4, and evaporated under reduced pressure to afford a crude product which was purified by column chromatography using silica gel and ethyl acetate:Hexane (1:1) as eluent to afford Compound 50 as yellow solid (6.5 grams, 72% yield).1H NMR (500 MHz, CDCl3)-delta: 7.36-7.29 (m, 3H), 7.14-7.11 (m, 3H), 7.00 (s, 1H), 5.09 (s, 2H);13C NMR (125 MHz, CDCl3)-delta: 135.5, 132.9, 128.9, 128.2, 127.2, 123.3, 90.6, 53;MS (ESI), m/z: 285 (MH+), 307 (MNa+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 4238-71-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4238-71-5, name is 1-Benzyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[00238] To a cooled (-50 C) suspension of 1 -benzyl- lH-imidazole (1.58 g, 10.0 mmol) in anhydrous diethyl ether (50 mL) under nitrogen was added w-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at -50 C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL), acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of this precipitate gave a white solid which was suspended in methanol, treated with INHCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded the HC1 salt of Cap- 136 as a white solid (817 mg, 40%). XH NMR (300 MHz, DMSO-d6) delta 7.94 (d, J= 1.5 Hz, 1H), 7.71 (d, J= 1.5 Hz, 1H), 7.50-7.31 (m, 5H), 5.77 (s, 2H); Rt = 0.51 min (Cond.-MS- W5); 95% homogenity index; LRMS: Anal. Calc. for [M+H C11H12 2O2: 203.08;found: 203.11.

The synthetic route of 1-Benzyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; ROMINE, Jeffrey, Lee; NGUYEN, Van, N.; WANG, Gan; LOPEZ, Omar, D.; ST. LAURENT, Denis, R.; CHEN, Qi; BENDER, John, A.; YANG, Zhong; HEWAWASAM, Piyasena; XU, Ningning; MEANWELL, Nicholas, A.; EASTER, John, A.; SU, Bao-Ning; SMITH, Michael, J.; WO2011/75439; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 4238-71-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4238-71-5 as follows.

To a cooled (-50 C) suspension of 1 -benzyl- lH-imidazole (1.58 g, 10.0 mmol) in anhydrous diethyl ether (50 mL) under nitrogen was added w-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at -50 C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL), acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of this precipitate gave a white solid which was suspended in methanol, treated with IN HCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded the HC1 salt of Cap- 136 as a white solid (817 mg, 40%). 1H NMR (300 MHz, DMSO-d6) delta 7.94 (d, J= 1.5 Hz, 1H), 7.71 (d, J= 1.5 Hz, 1H), 7.50-7.31 (m, 5H), 5.77 (s, 2H); Rt = 0.51 min (Cond.-MS- W5); 95% homogenity index; LRMS: Anal. Calc. for [M+H C11H12N2O2: 203.08;found: 203.11.

According to the analysis of related databases, 4238-71-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 4238-71-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4238-71-5, name is 1-Benzyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a cold (-50 0C) suspension of 1 -benzyl -IH- imidazole (1.58 g, 10.0 ramol) in anhydrous diethyl ether (50 mL) under nitrogen was added ?-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at -50 0C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 0C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL) , acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of the precipitate gave a white solid which was suspended in methanol, treated with IN HCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded Cap-136 as a white solid (817 mg, 40%) . 1H NMR (300 MHz, DMSO~d6) 6 7.94 (d, J = 1.5 Hz, IH), 7.71 (d, J = 1.5 Hz, IH) , 7.50-7.31 (m, 5H),5.77 (s, 2H} ; Rt = 0.51 min (Cond. -MS-W5) ; 95% homogenity index; LRMS: Anal. CaIc. for [M+H] + CnH12N2O2: 203.08; found: 203.11.

The synthetic route of 1-Benzyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAVOIE, Rico; BENDER, John A.; BACHAND, Carol; RUEDIGER, Edward H.; KADOW, John F.; WO2010/120621; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 4238-71-5, name is 1-Benzyl-1H-imidazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H10N2

1 mol of the compound III obtained in the step (1)1 mol of benzyl chloride was dissolved in THF (tetrahydrofuran)Heated to reflux 12h,The above solution was spin-dry with a rotary evaporator,Then using 3: 1 CH 2 Cl 2 and CH 3 OH as the eluent for chromatographic separation,Obtained pale yellow oily liquid, which is Compound II;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4238-71-5, its application will become more common.

Reference:
Patent; Jiangsu Atomic Medical Institute; Lin Jianguo; Lv Gaochao; Qiu Ling; Guo Liubin; Yang Hui; Wang Tengfei; (17 pag.)CN104650155; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 4238-71-5,Some common heterocyclic compound, 4238-71-5, name is 1-Benzyl-1H-imidazole, molecular formula is C10H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled (-50 C) suspension of 1 -benzyl- 1H- imidazole (1.58 g, 10.0 mmol) in anhydrous diethyl ether (50 mL) under nitrogen was added w-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at – 50 C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL), acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of this precipitate gave a white solid which was suspended in methanol, treated with INHCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded the HC1 salt of Cap-136 as a white solid (817 mg, 40%). XH NMR (300 MHz, DMSO-d6) delta 7.94 (d, J= 1.5 Hz, 1H), 7.71 (d, J= 1.5 Hz, 1H), 7.50-7.31 (m,5H), 5.77 (s, 2H); Rt = 0.51 min (Cond.-MS-W5); 95% homogenity index; LRMS: Anal. Calc. for [M+H]+ CnH12N202: 203.08; found: 203.11.

The synthetic route of 4238-71-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ROMINE, Jeffrey Lee; WO2012/18325; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

4238-71-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4238-71-5 as follows.

To a cold (-50 0C) suspension of 1 -benzyl -IH- imidazole (1.58 g, 10.0 ramol) in anhydrous diethyl ether (50 mL) under nitrogen was added ?-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at -50 0C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 0C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL) , acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of the precipitate gave a white solid which was suspended in methanol, treated with IN HCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded Cap-136 as a white solid (817 mg, 40%) . 1H NMR (300 MHz, DMSO~d6) 6 7.94 (d, J = 1.5 Hz, IH), 7.71 (d, J = 1.5 Hz, IH) , 7.50-7.31 (m, 5H),5.77 (s, 2H} ; Rt = 0.51 min (Cond. -MS-W5) ; 95% homogenity index; LRMS: Anal. CaIc. for [M+H] + CnH12N2O2: 203.08; found: 203.11.

According to the analysis of related databases, 1-Benzyl-1H-imidazole, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAVOIE, Rico; BENDER, John A.; BACHAND, Carol; RUEDIGER, Edward H.; KADOW, John F.; WO2010/120621; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem