Introduction of a new synthetic route about 41716-18-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 41716-18-1, The chemical industry reduces the impact on the environment during synthesis 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

Into a 50 mL round bottom flask equipped with a magnetic stir bar was placed 1-methyl-1H-imidazole-4-carboxylic acid (121 mg, 0.93 mmol), DMF (10 mL), ACN (20 mL), DIPEA(0.321 mL, 1.864 mmol), and HATU (378 mg, 0.99 mmol). This mixture was allowed tostirS mm at room temperature, afterwards 11(400 mg, 0.621 mmol) was added. The flaskwas sealed and allowed to stir at room temperature for 24 hours. The reaction mixture was reduced in volume, then poured into water (400 mL), and partitioned with ethyl acetate (3 x 100 mL). The organic layers were combined, dried over sodium sulfate, the solids were removed by filtration, and the solvent of the filtrate was removed underreduced pressure. The crude was purified by silica gel column chromatography using a n-heptane to ethyl acetate gradient. The best fractions were pooled and the solvent was removed under reduced pressure to afford 12. LC-MS ES mlz = 638.5; Rt: 2.34 mm, method B.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; GUILLEMONT, Jerome Emile Georges; COOYMANS, Ludwig Paul; EMBRECHTS, Werner Constant Johan; BUYCK, Christophe Francis Robert Nestor; BALEMANS, Wendy Mia Albert; RABOISSON, Pierre Jean-Marie Bernard; (34 pag.)WO2017/89518; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Simple exploration of C5H6N2O2

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1-Methyl-1H-imidazole-4-carboxylic acid

To a solution of (+/-) -cis-N1- (2-chloro-6- (furan-2-yl) pyrimidin-4-yl) cyclohexane -1, 3-diamine (150 mg, 0.51 mmol) in a mixed solvent of tetrahydrofuran (4 mL) and dimethyl sulfoxide (1 mL) were added N, N-diisopropylethylamine (0.26 mL, 1.54 mmol) and 1-methyl-1H-imidazole-4-carboxylic acid (129 mg, 1.03 mmol) . The mixture was stirred at rt for 10 minitues, and then HATU (389 mg, 1.03 mmol) was added. The resulting mixture was stirred at rt for 3 h. The reaction mixture was diluted with water (20 mL) , and the resulting mixture was extracted with EtOAc (20 mL× 3) . The combined organic layers were washed with saturated brine (50 mL) , dried over anhydrous Na2SO4, and filtered. The filtrate was concentrated in vacuo to give the title compound as a colorless solid (150 mg, 73percent) .[0587]MS (ESI, pos. ion) m/z: 401.2 [M+H]+.

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extracurricular laboratory: Synthetic route of 1-Methyl-1H-imidazole-4-carboxylic acid

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

Reference of 41716-18-1, A common heterocyclic compound, 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1) N-Methoxy-N-methyl-1-methyl-1H-imidazole-4-carboxamide 1-Methyl-1H-imidazole-4-carboxylic acid (1.26 g), N,O-dimethylhydroxylamine hydrochloride (1.17 g), 1-hydroxybenzotriazole (1.84 g), triethylamine (2.09 mL), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.30 g) were dissolved in N,N-dimethylformamide (50 mL), and the solution was stirred overnight at room temperature. The reaction solvent was evaporated under reduced pressure, and ethanol was added to the residue. Insoluble matter was removed through filtration, and the solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform – methanol – water, lower phase), to thereby give N-methoxy-N-methyl-1-methyl-1H-imidazole-4-carboxamide as a solid product (1.08 g, 64percent). 1H-NMR(400MHz,CDCl3)delta:3.45(3H,s), 3.73(3H,s), 3.78(3H,s), 7.45(1H,s),7.54(1H,s).

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

The origin of a common compound about 1-Methyl-1H-imidazole-4-carboxylic acid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Methyl-1H-imidazole-4-carboxylic acid

A mixture of the amine 32 (500 mg, 1.5 mmol), N-methyl-imidazol-4-yl carboxylic acid ( 212 mg, 1.7 mmol), HOBT (218 mg, 1.6 mmol), DCC (353 mg, 1.8 mmol) and triethyl amine (0.64 ml, 4.6 mmol) in dry dichloromethane (15 ml) was stirred at room temperature for 5 days. The reaction mixture was poured into ethyl acetate and washed with 1 N NaOH (1 X), brine (1 X), dried and concentrated. The crude product was purified by chromatography using the ISCO purification system to provide the desired product 33 (590 mg) as a solid. 1H NMR (400 MHz, CHLOROFORM-d) deltappm 1.25 (s, 2 H) 1.43 (s, 8 H) 1.58 (s, 5 H) 1.85 (s, 2 H) 2.01 (s, 1 H) 2.14 (s, 1 H) 2.50 (s, 3 H) 2.58 (s, 1 H) 2.74 (s, 1 H) 3.69 (s, 5 H) 3.88 (s, 1 H) 5.18 (s, 1 H) 7.25 (S, 2 H) 7.40 (s, 2 H); LCMS (m/z) 435.0 (M+H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

New learning discoveries about 1-Methyl-1H-imidazole-4-carboxylic acid

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

Related Products of 41716-18-1,Some common heterocyclic compound, 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Triethylamine (31 muL, 0.22 mmol) was added to a solution of 1-methyl-1H-imidazole-4-carboxylic acid (Combi-Blocks, catNo.HI-1090: 11 mg, 0.088 mmol), 2,2,2-trifluoro-N-[(4-methylpiperidin-4-yl)methyl]-N-[(1R,2S)-2-phenylcyclopropyl]acetamide (Example 44, Step 3: 15 mg, 0.044 mmol) and (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (46 mg, 0.088 mmol) in N,N-dimethylformamide (0.8 mL). The resulting mixture was stirred at room temperature for 4 h then NaOH (15 wt percent in water, 0.5 mL) was added. The reaction mixture was stirred at 40° C. overnight then cooled to room temperature and purified by prep-HPLC (pH=2, acetonitrile/water+TFA) to give the desired product as the TFA salt. LC-MS calculated for C21H29N4O (M+H)+: m/z=353.2. found 353.2.

The synthetic route of 41716-18-1 has been constantly updated, and we look forward to future research findings.

Brief introduction of 1-Methyl-1H-imidazole-4-carboxylic acid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41716-18-1, Safety of 1-Methyl-1H-imidazole-4-carboxylic acid

f) {(S)-3-[1-(6-Methoxy-5-methyl-pyridin-3-yl)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazin-7-yloxy]-pyrrolidin-1-yl}-(1-methyl-1H-imidazol-4-yl)-methanone A mixture of 1-methyl-1H-imidazole-4-carboxylic acid (CAS registry 41716-18-1) (15 mg, 0.12 mmol), HBTU (53 mg, 0.14 mmol) and DIPEA (0.025 ml, 0.14 mmol) in DMF (0.6 ml) was stirred at rt for 5 min. A solution of 1-(6-methoxy-5-methyl-pyridin-3-yl)-7-((S)-pyrrolidin-3-yloxy)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine (0.037 g, 0.11 mmol) in DMF (0.6 ml) was added. After stirring for 20 h at rt water was added and the reaction mixture and was extracted with EtOAc. Combined organic layers were washed with brine, dried over Na2SO4, filtered and evaporated. The crude product was purified by prep. RP-HPLC (column SunFire C18, H2O+0.1percent TFA/ACN+0.1percent TFA 90:10 to 60:40 in 16 min) to provide the title compound as a pale yellow foam (24 mg, 49percent yield). HPLC RtM1=0.74 min; ESIMS: 451 [(M+H)+]. 1H NMR (400 MHz, DMSO): delta 8.00 (m, 1H), 7.58-7.63 (m, 3H), 7.53 (d, 1H), 5.51 (d, 1H), 5.29-5.40 (m, 1H), 4.23-4.29 (m, 2H), 3.99 (s, 3H), 3.77-4.19 (m, 2H), 3.66 (m, 5H), 3.39-3.63 (m, 2H), 2.15 (s, 3H), 1.89-2.11 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Continuously updated synthesis method about 1-Methyl-1H-imidazole-4-carboxylic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-4-carboxylic acid, its application will become more common.

Electric Literature of 41716-18-1,Some common heterocyclic compound, 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 1-methyl-1Himidazole-4-carboxylic acid (0.50 g, 4.0 mmol), 1-hydroxybenztriazole monohydrate (0.74 g, 4.8 mmol), and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.92 g, 4.8 mmol) in acetonitrile (10 mL) was added a solution of 3-(trifluoromethoxy) benzylamine 8(0.84 g, 4.4 mmol) in acetonitrile (10 mL), and the mixture was stirred at room temperature for overnight. The reaction mixture was concentrated in vacuo, and saturated aqueous NaHCO3solution was added to the residue. After extraction with ethyl acetate, the organic layer was dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified using silica gel column chromatography (0?10percent MeOH in CHCl3) to obtain 9(1.18 g, 98percent) as a colorless powder

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-4-carboxylic acid, its application will become more common.

The important role of 1-Methyl-1H-imidazole-4-carboxylic acid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 41716-18-1

To a solution of intermediate 72-d.HCl (3.0 g, 4.61 mmol) in DMF cooled to 0° C. were sequentially added 1-N-methylimidazole carboxylic acid (988 mg, 7.83 mmol), HATU (2.98 g, 7.83 mmol) and DIPEA (3.22 mL, 18.43 mmol) and the reaction mixture was stirred at room temperature overnight. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 77-a as white foam.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

The origin of a common compound about 1-Methyl-1H-imidazole-4-carboxylic acid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 41716-18-1

Synthesis of { 2- ( 6-chloropyridin-3-yl ) -4- ( 2- methoxyethoxy ) -7, 8-dihydropyrido [4, 3-d] pyrimidin-6 (5H) – yl) ( l-neio-lif-imidazol-4-yl ) }methanone (compound no. 6) is shown in scheme 4. l-Tert-butyl-3-ethyl-4-oxopiperidine-l, 3- dicarboxylate (12) underwent a facile three-component condensation with 6-chloropyridine-3-carboximidamide hydrochloride (13) and 2-bromoethyl methyl ether followed by Boc- deprotection to afford advanced an intermediate 14, which was coupled with l-methyl-l.fi-imidazole-4-carboxylic acid (15) (Scheme 4) . See, Raheem, et al., Bioorg. Med. Chem. Lett. 22:5903-5908 (2012) .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.

Reference:
Patent; UNIVERSITY OF SOUTH ALABAMA; PIAZZA, Gary, A.; WO2015/6689; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extracurricular laboratory: Synthetic route of 1-Methyl-1H-imidazole-4-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-4-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41716-18-1, Recommanded Product: 41716-18-1

[00393] To a solution of (+/?)-cis-N1-(2-chloro-7-methyl-7H-pyrrolo[2,3 -d]pyrimidin-4-yl)cyclohexane-i,3-diamine (110.5 mg, 9 mmol) in a mixed solvent of tetrahydrofuran (4 mL) and dimethyl sulfoxide (1 mL) was added N,N-diisopropylethylamine (0.16 mL, 1.19 mmol) and i-methyl-1H-imidazole-4-carboxylic acid (99 mg, 0.78 mmol). The mixture was stirred at rt for 10 minitues, and then HATU (300 mg, 0.79 mmol) was added. The resulting mixture was stirred at rt for 3 h. To the reaction mixture was added water (10 mL), and the resulting mixture was extracted with ethyl acetate (10 mL x 3). The combined organic layers were washed with saturated brine (30 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a colorless solid (86 mg, 56percent).MS (ESI, pos.ion) m/z: 388.2 [M+H]+1H NMR (400 MHz, MeOD) (ppm) : 7.65 (d, J 6.1 Hz, 2H), 6.99 (d, J 3.3 Hz, 1H), 6.56 (d,J = 3.4 Hz, 1H), 3.78 (s, 3H), 3.72 (s, 3H), 2.68 (s, 2H), 2.34 (d, J = 11.6 Hz, 1H), 2.06 (s, 2H),1.93 (d, J = 13.6 Hz, 1H), 1.61 (d, J = 13.5 Hz, 1H), 1.44 (d, J = 11.7 Hz, 1H), 1.39 (d, J = 3.6Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem