Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41270-74-0, name is 5-Phenyl-1H-imidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., Quality Control of 5-Phenyl-1H-imidazole-2-carboxylic acid
To a solution of intermediate 12-g (229 mg, 0.44 mmol) in DMF, cooled to 0¡ã C., were sequentially added 5-phenyl-1H-imidazole-2-carboxylic acid (195 mg, 0.87 mmol), HATU (220 mg, 0.57 mmol) and DIPEA (310 uL, 1.78 mmol) and the reaction mixture was stirred at 0¡ã C. for 1 hour. Saturated aqueous ammonium chloride and ethyl acetate were added; the organic layer was separated, washed with saturated aqueous ammonium chloride, saturated aqueous NaHCO3 and brine, dried over anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 60-a as a white foam.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Pharmascience Inc.; Laurent, Alain; Proulx, Melanie; Rose, Yannick; Denissova, Irina; Dairi, Kenza; Jarvis, Scott; Jaquith, James B.; (189 pag.)US9284350; (2016); B2;,
Imidazole – Wikipedia,
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