Category: 41010-50-8

On February 28, 1979, Svertilova, I. A.; Yutilov, Yu M. published an article.Recommanded Product: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Condensed imidazolones. And the article contained the following:

Eight imidazolones I (X, Y = CH, N; R = H, Me, Ph, benzyl; R1 = H, Me, Et, Ph, benzyl) were prepared in 90-9% yield by cyclocondensation of diamines II with (EtO2C)2O. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Recommanded Product: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to cyclocondensation pyrocarbonate pyridinediamine, phenylenediamine pyrocarbonate cyclocondensation, imidazolone condensed, benzimidazolone, imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Recommanded Product: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying; Jacobus, David P.; Jones, Howard; Lotti, Victor J.; Flataker, Lars M. published an article in 1978, the title of the article was Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

One hundred-thirty imidazo[4,5-b]pyridin-2-ones (I, R = H or alkyl, X = H, halo, alkyl, NH2, etc.) and 60 triazolo[4,5-b]pyridines (II, X = H, halo, alkyl, alkoxy, NO2, etc.) were prepared, eg by cyclizing 3-nitro-2-anilinopyridines with COCl2, urea, or NaNO2. I and II increased the pain threshold of both the inflammed and the normal foot in a modified Randall-Selitto test. I (R = H, X = 3,4-OCH2O), I (R = allyl, X = 3,4-OCH2O), I (R = CHMe2, X = 3,4-OCH2O), II (X = H) and II (X = F) were the most active compounds The analgesic activity of I was superior to that of codeine or D-propoxyphene, while showing no narcotic characteristics. Some I and II were effective in the carrageenin edema test. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to phenylimidazopyridinone preparation analgesic, phenyltriazolopyridine preparation analgesic, imidazopyridinone phenyl preparation analgesic, triazolopyridine phenyl preparation analgesic and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 2, 2016, Youn, So Won; Kim, Yi Hyun published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates. And the article contained the following:

A simple and facile one-pot reaction has been developed to afford a diverse range of N,N’-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramol. C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)2 Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to disubstituted benzimidazolone imidazopyridinone preparation palladium silver promoted sequential reaction, cyclic urea preparation addition amidation hetero aromatic amine isocyanate and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying; Jacobus, David P.; Jones, Howard; Lotti, Victor J.; Flataker, Lars M. published an article in 1978, the title of the article was Synthesis and analgesic activity of 1,3-dihydro-3-(substituted phenyl)imidazo[4,5-b]pyridin-2-ones and 3-(substituted phenyl)-1,2,3-triazolo[4,5-b]pyridines.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

One hundred-thirty imidazo[4,5-b]pyridin-2-ones (I, R = H or alkyl, X = H, halo, alkyl, NH2, etc.) and 60 triazolo[4,5-b]pyridines (II, X = H, halo, alkyl, alkoxy, NO2, etc.) were prepared, eg by cyclizing 3-nitro-2-anilinopyridines with COCl2, urea, or NaNO2. I and II increased the pain threshold of both the inflammed and the normal foot in a modified Randall-Selitto test. I (R = H, X = 3,4-OCH2O), I (R = allyl, X = 3,4-OCH2O), I (R = CHMe2, X = 3,4-OCH2O), II (X = H) and II (X = F) were the most active compounds The analgesic activity of I was superior to that of codeine or D-propoxyphene, while showing no narcotic characteristics. Some I and II were effective in the carrageenin edema test. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to phenylimidazopyridinone preparation analgesic, phenyltriazolopyridine preparation analgesic, imidazopyridinone phenyl preparation analgesic, triazolopyridine phenyl preparation analgesic and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 2, 2016, Youn, So Won; Kim, Yi Hyun published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Pd(II)/Ag(I)-Promoted One-Pot Synthesis of Cyclic Ureas from (Hetero)Aromatic Amines and Isocyanates. And the article contained the following:

A simple and facile one-pot reaction has been developed to afford a diverse range of N,N’-disubstituted benzimidazolones and imidazopyridinones containing two differently substituted N atoms. A cooperative Pd(II)/Ag(I) system promotes the sequential addition/intramol. C-H amidation reaction of (hetero)aromatic amines and isocyanates, leading to the formation of two C-N bonds. A mechanism involving radical intermediates generated by single-electron transfer (SET) in the presence of a Ag2CO3 oxidant and Pd(OAc)2 Lewis acid is proposed. This protocol offers an operationally easy, simple, and robust approach with the use of readily available starting materials, good functional group tolerance, and high efficiency. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to disubstituted benzimidazolone imidazopyridinone preparation palladium silver promoted sequential reaction, cyclic urea preparation addition amidation hetero aromatic amine isocyanate and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 13, 1979, Clark, Robert L.; Pessolano, Arsenio A.; Shen, Tsung-Ying published a patent.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the patent was Imidazopyridin-2-ones and pharmaceutical compositions and methods of treatment. And the patent contained the following:

Imidazopyridines I [R = H, C2-6 alkenyl, C1-7 alkyl (substituted with C3-6 cycloalkyl, C1-5 alkoxy, or OH), C4-7 cycloalkyl; R1, R2, R4 = H, 5- or 6-F, 5- or 6-Cl, 5- or 6-C1-5 alkoxycarbonylamino; R1R2 = OCR5R6O (R5, R6 = H, alkyl)] were prepared by several methods. Also prepared were 3-heterocyclyl analogs of I and 2-thiono analogs of I. I and their analogs were analgesics, antipyretics, and antiinflammatory agents (no data). Thus, refluxing 2-chloro-3-nitropyridine with 3,4-(OCH2O)C6H3NH2 in NaOAc-AcOH 5 h gave nitropyridine II (R7 = NO2) which was hydrogenated over Pd/C in MeOH and the diamine II (R7 = NH2) cyclized with COCl2 overnight at room temperature to give I (R = R4 = H, R1R2 = 3,4-OCH2O), which was converted into a variety of I (R = alkyl, alkenyl, acyl, R1R2 = OCH2O, R4 = H). The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to analgesic imidazopyridinone preparation, antipyretic imidazopyridinone preparation, antiinflammatory imidazopyridinone preparation, imidazopyridinone pharmaceutical preparation, aminoanilinopyridine cyclization phosgene and other aspects.Quality Control of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem