Category: 41010-50-8

Naumchuk, V. M.; Volynets, G. P.; Gorbatiuk, O. B.; Lukashov, S. S.; Bdzhola, V. G.; Yarmoluk, S. M. published an article in 2015, the title of the article was Investigation of inhibitory activity of imidazolone derivatives and their precursors toward human protein kinase CK2.Formula: C12H9N3O And the article contains the following content:

We have investigated inhibitory activity of imidazolone derivatives and their precursors toward protein kinase CK2. As a result, we have found seven inhibitors with IC50 values in the range from 8 to 30 μM. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Formula: C12H9N3O

The Article related to protein kinase imidazolone derivative non cyclic precursor inhibition, Enzymes: Other and other aspects.Formula: C12H9N3O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 3, 1977, Schweisguth, Bernard published a patent.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the patent was (Morpholinylmethyl)benzimidazolinones. And the patent contained the following:

Antidepressant morpholine derivatives I (R = Me, Me2CH, Ph, PhCH2; R1 = H, 6-Cl, 5-MeO; R2 = H, PhCH2; X = N, CH) (12 compounds) were prepared Thus, 1-methyl-2,3-dihydro-2-benzimidazolone reacted with NaH and 2-(chloromethyl)-4-benzylmorpholine to give I (R = Me, R1 = H, R2 = PhCH2), which was hydrogenated to I (R2 = H). I are useful as antidepressants at 50-150 mg/day for humans. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to morpholinylmethylbenzimidazolone, antidepressant morpholinylmethylbenzimidazolone, benzimidazolone morpholinylmethyl, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines and other aspects.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 30, 2006, Yutilov, Yu. M.; Smolyar, N. N.; Lomov, D. A. published an article.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Synthesis of 1- and 3-substituted imidazo[4,5-b]pyridin-2-ones. And the article contained the following:

1- And 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210°. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p’-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, resp. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to cyclization aminochloropyridine urea arylamine preparation imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 14, 2016, Tang, Long; Yin, Yue; Feng, Xiaoqing published a patent.Synthetic Route of 41010-50-8 The title of the patent was Method for synthesizing Pirenzepine hydrochloride key intermediate. And the patent contained the following:

The title method comprises the steps of: conducting rearrangement reaction on 1,3-dihydro-3-phenyl-2H-imidazo[4,5-B]pyridine-2-one under the action of an acidic catalyst to generate 5,11-dihydro-6H-pyrido[2,3-B][1,4]benzodiazepine-6-one, extracting with Et acetate, drying with anhydrous magnesium sulfate, and recrystallizing with anhydrous ethanol-petroleum ether mixed solvent. The method has the advantages of simple process and raw materials, little pollution, and high yield (above 99%), and recycles Et acetate and acidic catalyst, so as to save cost and protect environment. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Synthetic Route of 41010-50-8

The Article related to dihydro pyrido benzodiazepinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Synthetic Route of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 16, 1976, Clark, Robert Long; Pessolano, Arsenio A.; Shen, Tsung-Ying published a patent.HPLC of Formula: 41010-50-8 The title of the patent was 1,3-Dihydroimidazo[4,5-b]pyridin-2-ones and thiones. And the patent contained the following:

Imidazopyridinones and thiones I [R = e.g. H, Pr, H2C:CHCH2, Me, PhCH2; R1 = e.g. Ph, 2,4-(MeO)2C6H3, 2,4-Me2C6H3, 3,4-(OCH2O)C6H3, 2-BrC6H4, 3-FC6H4, 2-methyl-6-pyridinyl, 1,3-dihydro-5-isobenzofuranyl; R2 = e.g. H, 6-Me, 6-NO2, 6-NH2; X = O, S], useful as analgesics, antipyretics and inflammation inhibitors (no data), are prepared by reaction of 2-chloro-3-nitropyridine (II) with an aniline, reduction of the resulting 2-anilino-3-nitropyridine to the 3-amino-2-anilinopyridine and cyclocondensation with COCl2 or CSCl2, for example. Thus, reaction of II with 3,4-methylenedioxyaniline gives 2-[3,4-(methylenedioxy)anilino]-3-nitropyridine, which is reduced and cyclocondensed with COCl2 to give I [R = R2 = H, R1 = 3,4-(OCH2O)C6H3, X = O]. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).HPLC of Formula: 41010-50-8

The Article related to imidazopyridinone, imidazopyridinethione, analgesic imidazopyridinone, antipyretic imidazopyridinone, antiinflammatory imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.HPLC of Formula: 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 6, 1973, Robison, Michael Mullen; Finch, Neville published a patent.Product Details of 41010-50-8 The title of the patent was 1-(Aminoalkyl)-2,3-dihydroimidazo[4,5-b]pyridines. And the patent contained the following:

About 15 title compounds (I; R = cyclohexyl, PhCH2, Ph, p-FC6H4, etc.; R1 = MeN, 4-methyl-1-piperazinyl; X = O, S; n = 2,3) were prepared Thus, 2-chloro-3-nitropyridine was treated with PhNH2 and the product hydrogenated (PdC ) to give 3-amino-2-(phenylamino) pyridine, which was treated with 1,1′-carbonyldiimidazole to give 2-oxo-3-phenyl-2,3- dihydroimidazo[4,5-b]pyridine followed by treatment with Me2NCH2- CH2Cl to give I (R = Ph, R1 = Me2N, X = O, n = 2) isolated as the dicyclohexylsulfamate salt. I were intidepressant at 2.5-100 mg/kg/day in higher animals. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Product Details of 41010-50-8

The Article related to imidazopyridine aminopropyl phenyl antidepressant, antidepressant aminopropylimidazopyridine, pyridine nitro chloro aniline addition, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 1976, Yutilov, Yu. M.; Svertilova, I. A. published an article.Computed Properties of 41010-50-8 The title of the article was New method for preparing condensed imidazolones. And the article contained the following:

Imidazoles I and II (X = CH, N; R = H, Cl; R1 = H, Me, Et, R2 = H, Me, Ph, CH2Ph) were obtained in 80-99% yields by treatment of the corresponding o-phenylenediamine or diaminopyridine with EtO2COCO2Et. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Computed Properties of 41010-50-8

The Article related to cyclocondensation phenylenediamine pyrocarbonate, pyridinediamine cyclocondensation polycarbonate, imidazolone condensed, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Computed Properties of 41010-50-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 17, 2006, Scott, Jeremy P. published an article.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Two-step synthesis of 3-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones. And the article contained the following:

One-pot tandem palladium-catalyzed amination and intramol. amidation of tert-Bu (2-chloropyridin-3-yl)carbamate with substituted primary anilines allows for the preparation of 3-arylated 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones (49-90% yield) in two steps from com. available materials. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to chloropyridinylcarbamate primary aniline tandem amination intramol amidation, imidazopyridinone dihydro preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Doan, Sengul Dilem; Ongun, Melike published an article in 2022, the title of the article was Copper catalyzed C-N bond formation and synthesis of imidazopyridinone derivatives.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one And the article contains the following content:

A series of novel imidazopyridinone derivatives were synthesized via copper-mediated C-N bond-forming reaction. This reaction takes place under mild conditions with high efficiency, step economy, and tolerance for a wide range of functional groups. All synthesized new compounds were analyzed by 1H NMR, 13C NMR and mass spectrometry. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to bromopyridylphenylurea copper iodide catalyst microwave intramol cyclization, imidazopyridinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 1983, Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; Moimas, F.; Angeli, C.; Zonno, F.; Toso, R.; Sunjic, V. published an article.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was New synthesis of 11-acyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones and related studies. And the article contained the following:

11-Acyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones I (R = 4-methylpiperazino, imidazolo, 2-methylimidazolo) were prepared via N-α-chloroacetylation and aminolysis. Other attempts at cyclization to form I are also reported. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to aminoacetylpyridobenzodiazepinone, pyridobenzodiazepinone aminoacetyl, benzodiazepinone pyrido, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem