Category: 39861-21-7

Synthetic Route of 39861-21-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39861-21-7, name is 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Further, compounds 4 (0.35-0.50 mmol, 1.0 eq) were heated withchloroacetyl chloride (3.0 eq) in anhydrous toluene (10 mL) to 90 C for2 h. This reaction mixture was concentrated under reduced pressureand the residue was triturated with diethyl ether (10 mL). The productwas filtered and subsequently washed with multiple portions of diethylether (3×5 mL) and dried to recover colored solids. The solids werevigorously stirred in a saturated solution of NaHCO3 (10 mL) for30 min, acidified to neutral pH by aqueous 1M HCl solution and thenextracted with multiple portions of ethyl acetate (5×10 mL) until theaqueous layer turns colorless. The combined organic extracts werewashed with brine (10 mL), dried over sodium sulfate (10 g), were filteredand concentrated to yield pure amides 5 as colored solids in70-90% yield.

The chemical industry reduces the impact on the environment during synthesis 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ankenbruck, Nicholas; Kumbhare, Rohan; Naro, Yuta; Thomas, Meryl; Gardner, Laura; Emanuelson, Cole; Deiters, Alexander; Bioorganic and Medicinal Chemistry; vol. 27; 16; (2019); p. 3735 – 3743;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 39861-21-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39861-21-7 as follows.

(c) N-[4-(5-Chloro-1H-benzoimidazol-2-yl)phenyl]-2-cyclohexylmethyl-succinamic acid This compound was prepared by the procedure described in Example 1 part (a) from 4-(5-Chloro-1H-benzoimidazol-2-yl) phenylamine and (R)-2-(Cyclohexylmethyl) succinic acid 1-methyl ester to give the crude product (2.0 g, 51%), which was used in the next step without further purification.

According to the analysis of related databases, 39861-21-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US6313117; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 39861-21-7, These common heterocyclic compound, 39861-21-7, name is 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(c) N-[4-(5-Chloro-1H-benzoimidazol-2-yl)-phenyl]-2-cyclohexylmethyl-succinamic acid methyl Ester This compound was prepared by the procedure described in Example 1 part (a) from 4-(5-Chloro-1H-benzoimidazol-2-yl)-phenylamine and (R)-2-(Cyclohexylmethyl) succinic acid 1-methyl ester to give the crude product (2.0 g, 51%), which was used in the next step without further purification.

The synthetic route of 39861-21-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bekkali, Younes; Betageri, Rajashehar; Emmanuel, Michel Jose; Hickey, Eugene Richard; Liu, Weimin; Patel, Usha R.; Spero, Denice Mary; Thomson, David S.; Ward, Yancey David; Young, Erick Richard Roush; US2001/41700; (2001); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 39861-21-7, These common heterocyclic compound, 39861-21-7, name is 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a well stirred solution of the corresponding 4-(sub:-1Hbenzo[d]imidazol-2-yl)aniline/4-(3H-imidazo[4,5-b]pyridin-2-yl)aniline (3a-f) (1 equiv) and triethylamine (2.5 equiv) indichloromethane was added the appropriate dicarboxylic acid(1 equiv) followed by propylphosphonic anhydride solution(2.5 equiv; 50% solution in ethyl acetate) at 0 C. The reactionmixture was warmed to room temperature and stirred at roomtemperature for 8h (monitored by TLC and LCMS for completion).The reaction mixture was then washed with water, brine driedover anhydrous sodium sulfate and concentrated under reducedpressure. The residue obtained was then purified by flash chromatographyto afford the desired product in good yield and purity asdescribed below.

Statistics shows that 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline is playing an increasingly important role. we look forward to future research findings about 39861-21-7.

Reference:
Article; Janupally, Renuka; Jeankumar, Variam Ullas; Bobesh, Karyakulam Andrews; Soni, Vijay; Devi, Parthiban Brindha; Pulla, Venkat Koushik; Suryadevara, Priyanka; Chennubhotla, Keerthana Sharma; Kulkarni, Pushkar; Yogeeswari, Perumal; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5970 – 5987;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem