Category: 39811-07-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 39811-07-9

5-Fluoro-1H-benzimidazole-2-carboxylic acid 45 was synthesised using 5-fluoro-1H-benzimidazole-2-yl)methanol 29 (0.10 g, 0.60 mmol) dissolved in acetone (20 mL) and potassium permanganate (0.10 g, 0.63 mmol) dissolved in water (10 mL). 5-Fluoro-1H-benzimidazole-2-carboxylic acid 45 was recovered as bright white crystals in Yield 38%. mp 166-168 C.

According to the analysis of related databases, 39811-07-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 39811-07-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.

Thionyl chloride (27.5 mmol, 2 mL) was added slowly to a solution of 5-flouro-1H-benzimidazole-2-yl)-methanol) (FAS27) (0.55 g, 3.31 mmol) in dichloromethane (10 mL) at 10 C, the mixture was stirred until no presence of the starting material. The solvent was then evaporated, and the residue was triturated with dichloromethane, suction filtered, washed with dichloromethane and ether. 2-(Chloromethyl)- 5-flouro-1H-benzimidazole 45 was recovered as a brown powder in Yield 80%.

The chemical industry reduces the impact on the environment during synthesis (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol. I believe this compound will play a more active role in future production and life.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 39811-07-9, These common heterocyclic compound, 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-Methyl-2-methanol-5-flourobenzimidazole 51 was prepared according to using the procedure by Harisha et al. [28]. A solution of (5-fluoro-1H-benzimidazole-2-yl) methanol 29 (0.42 g, 2.5 mmol), and sodium hydroxide (0.1 g, 2.5 mmol) were stirred in dry acetone (8 mL) for 30 min. Then, iodomethane (0.35 g, 2.5 mmol) was added and the mixture was stirred for 24 h. The reaction mixture was concentrated to a quarter and then poured into ice-cold water. The solid was filtered and washed with 50% HCl to neutralize the excess potassium carbonate. The solid was washed with cold water (25 mL) and aqueous ethanol. The desired product 51 was dried and recrystallized from ethanol to give pale cream crystals Yield 53%.

The synthetic route of 39811-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem