Category: 39513-26-3

Related Products of 39513-26-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a souUon of (2,3-dmethypheny)boronc add (85 mg, 0.56 mmd) and 5-bromo1 Hbenzo[d] mdazo-2(3H)-.one (100 mg, 0.45 mmd) n 4:1 doxane:water (2.0 mL) were added potassurn phosphate (199 mg, 0.94 mmo) and PdC2(dppf)CH2C2 (19 mg, 0.02 mmofl. The mixture was degassed wfth n[trogen and then heated at 100 C for 16 h. After coong to rt, the reacUon mixture was dUuted wth water and extracted w[th DCM (2X). The combined organic extracts were dried (Na2SO4), fUtered, and concentrated. Purification(FCC, Si02 0 – 50% EtOAc/hexanes) afforded the tifle compound as a white sod (71 mg,63%yied). MS(ES): mass cacd. for C15H14N20, 238.1; m/zfound, 239.1 [M-FH]4. 1HNMR (400 MHz, DMSO-d6) 5 10.64 (s, 2H), 7.20 7.07 (m, 2H), 6.98 (dd, J = 16.2, 7.3Hz, 2H), 6.88 -6.73 (m, 2H), 2.28 (5, 3H), 2.10 (5, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,3-dihydrobenzoimidazol-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Bromo-1,3-dihydrobenzoimidazol-2-one

To a round-bottomed flask containing DMF (35 mL) was added 5-bromo-1 ,3-dihydro- benzimidazo-2one (5.Og, 23 mmo), and the resu[ting soution was purged with nitrogen for 15 minutes. To this soution were added successivey bis(pinacoato)diboron (7.2g, 28mmo), potassium acetate (6.9g, 70 mmo), and PdC2(dppf)0H2C2 (1 .7g, 2.4 mmd). After heating at 95 C for 16 h, the back mixture was coded to rt and di?uted with brine (50 mL) and EtOAc (75 mL). The resu[ting precipitate was removed by fiftration and washed with EtOAc. The fiftrate was transferred to a separatory funnd and the ayers separated. The organic ayer was washed with water (3 x 50 mL), dried (Na2SO4), fiftered andconcentrated in vacuo. Trituration of the crude residue with DOM provided the desired product as a white soid (2.5g, 41 % yied). MS (ES): masss cacd. for 013H17BN203, 260.1; m/zfound, 261.2 [M+H1. 1H NMR (400 MHz, DMSO.-d6) 310.76 (s, IH), 10.65 (s, IH), 7.29 (dd, J= 7,7, 1.0 Hz, IH), 7.18 (s, IH), 6.92 (d, J= 7.5 Hz, IH), 127 (5, 12H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 39513-26-3.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Bromo-1,3-dihydrobenzoimidazol-2-one

EXAMPLE 9 5-(3-Nitro-phenyl)-1,3-dihydro-benzoimidazol-2-one Prepared from 5-bromo-1,3-dihydro-benzoimidazol-2-one and 3-nitro-phenyl boronic acid in the same fashion as that of Example 5. White solid: mp 324-325 C.; 1H-NMR (DMSO-d6) delta 10.8 (s, 2H), 8.4 (m, 1H), 8.15 (d, 1H, J=7.5 Hz), 8.1 (d, 1H, J=7.5 Hz), 7.7 (t, 1H, J=7.5 Hz), 7.35 (d, 1H, J=7.5 Hz), 7.3 (s, 1H), 7.05 (d, 1H), J=7.5 Hz); MS (ES) m/z 254 ([M-H]-, 100%); Anal. Calc. For C13H9N3O3: C, 61.18, H, 3.55, N, 16.46. Found: C, 60.5, H, 3.69 N, 15.53.

According to the analysis of related databases, 39513-26-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Home Products Corporation; Ligand Pharmaceutical, Inc.; US6423699; (2002); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 39513-26-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39513-26-3 name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 5-bromo-lH-benzo[d]imidazol-2(3H)-one104 (930 mg) in a mixture of dioxane (47 ml) and 1 M aqueous sodium carbonate (24 ml) was added 5- quinolylboronic acid105 (906 mg). The reaction mixture was purged three times with Argon before adding 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (0.358 g) and palladium(II) acetate (0.098 g). The reaction mixture was refluxed for 4 hours. Dioxane was removed by evaporation and ethyl acetate was added. The solid obtained was filtered, dissolved in dichloromethane and washed with water. The organic layer was dried over MgS04, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, eluent: 0 to 5% of methanol in dichloromethane) to afford 5-(2-isopropyl-lH-imidazol-l-yl)-2- nitroaniline (85mg, 27%) as an orange solid. MS (ISP): 247.2 ([M+H]+). The organic layer off and the filter cake was washed with methanol. The filtrate was concentrated in vacuo to 5- quinolin-5-yl-l,3-dihydro-benzoimidazol-2-one as a dark brown solid (949 mg). MS (ISP): 262.2 ([M+H]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-1,3-dihydrobenzoimidazol-2-one, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GOERGLER, Annick; NORCROSS, Roger; DEY, Fabian; KUSZNIR, Eric Andre; (206 pag.)WO2019/43217; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem