Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(2-Hydroxyethyl)isoindoline-1,3-dione
2-Phthalimidoethanol lNo.,lNo.,2No.,2No.-perfluorodecylsulfonate (23) ;hi a 10 mL round bottomed flask, distilled triethylamine (84 muL, 0.60 mmol) followed by lH,lH,2H,2H-perfluorodecyl sulfonyl chloride (328 mg, 0.60 mmol) were added to a stirred solution of N-(2-hydroxyethyi)phthalimide (96 mg, 0.50 mmol) in DCM (3 mL) at O0C under a nitrogen atmosphere. The mixture was allowed to stir for 3 hours whilst warming up to room temperature before being quenched with sodium carbonate solution and extracted with DCM (3 x 10 mL). The combined organic phases were washed with brine, dried over MgSO4, and the solvent removed under reduced pressure. The crude solid was washed with Et2O to afford the target compound as a white solid (256 mg, 0.366 mmol, 73% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; BEJOT, Romain; WO2010/7363; (2010); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem