Category: 38585-62-5

Electric Literature of 38585-62-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 7 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (49.97 g), p-toluenesulphonic acid monohydrate (9.50 g) and 4-hydroxymethyl-5-methylimidazole hydrochloride (20.25 g) in N-methylpyrrolidinone (250 ml) was stirred and heated to 125 (over 1 h) The reaction was then heated at 125-130 for 4.5 h, during which time two further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (17.51 g and 6.88 g) were added. The reaction mixture was cooled, diluted with water (100 ml), and the stirred mixture was treated slowly with 8% aqueous sodium bicarbonate (750 ml). The resultant suspension was stirred in an ice bath for 1 h and then filtered to give a solid (57.64 g). A portion of this solid (11.09 g) was dissolved in dichloromethane (307 ml) and ethanol (166 ml), boiled with decolourising charcoal for 10 min and then filtered. The dichloromethane was distilled off at atmospheric pressure until the temperature of the mixture was at 65. The stirred mixture was cooled and the resulting precipitate was filtered off to give the title compound (9.28 g), t.l.c. (System A, 50:8:1) Rf 0.55.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Glaxo Group Limited; US5196534; (1993); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 38585-62-5, A common heterocyclic compound, 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, molecular formula is C5H9ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one. A mixture of 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (49.97 g), p-toluenusulphonic acid monohydrate (9.50 g) and 4-hydroxymethyl-5-methylimidazole hydrochloride (20.25 g) in N-methylpyrrolidinone (250 ml) was stirred and heated to 125 (over 1 h) The reaction was then heated at 125-130 for 4.5 h, during which time two further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (17.51 g and 6.88 g) were added. The reaction mixture was cooled, diluted with water (100 ml), and the stirred mixture was treated slowly with 8% aqueous sodium bicarbonate (750 ml). The resultant suspension was stirred in an ice bath for 1 h and then filtered to give a solid (57.64 g). A portion of this solid (11.09 g) was dissolved in dichloromethane (307 ml) and ethanol (166 ml), boiled with decolourising charcoal for 10 min and then filtered. The dichloromethane was distilled off at atmospheric pressure until the temperature of the mixture was at 65. The stirred mixture was cooled and the resulting precipitate was filtered off to give the title compound (9.28 g), t.l.c. (dichloromethane: ethanol: 0.88 ammonia, 50:8:1) Rf 0.55. 1 H-n.m.r (DMSO-d6): delta2.20(3H,s), 3.03(2H,t), 3.64(2H,m), 3.71(3H,s), 4.50(2H,s), 7.19(2H,m), 7.44(1H,s), 7.50(1H,d), 7.99(1H,d), 11.76(1H,s).

The synthetic route of 38585-62-5 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 38585-62-5, name is (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride

EXAMPLE 26 6-Fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one A solution of 6-fluoro-2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (100 mg) in N-methylpyrrolidinone (10 ml) was treated with 4-toluenesulphonic acid monohydrate (17 mg) and 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg). The mixture was then heated to 125 for 18 h during which time three further portions of 4-hydroxymethyl-5-methylimidazole hydrochloride (37 mg) were added at 1,2 and 3 h respective. The solution was then poured into 8% sodium bicarbonate solution (100 ml) and extracted with dichloromethane (3*100 ml). The combined extracts were concentrated in vacuo and the N-methylpyrrolidinone was distilled at 100. The residue was purified by FCC eluding with System A (200:8:1) to give the title compound (100 mg), t.l.c. (System A, 100:8:1) Rf 0.3.

The synthetic route of (4-Methyl-1H-imidazol-5-yl)methanol hydrochloride has been constantly updated, and we look forward to future research findings.