Application of 384821-19-6, A common heterocyclic compound, 384821-19-6, name is N-Methyl-1-(1-methyl-1H-imidazol-5-yl)methanamine, molecular formula is C6H11N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7- carboxylic acid (600 mg, 1.45 mmol), HBTU (823 mg, 2.17 mmol), triethylamine (402 mul_, 2.9 mmol) in a 10/1 mixture of THF/DMF (15 ml_) was added, under an atmosphere of N2, (1-lambda/-methyl-imidazol-5-yl)methylamine (322 mg, 2.89 mmol). The reaction mixture was stirred at room temperature for 18 hours then quenched with water. The aqueous layer was extracted with AcOEt. The organic layer was allowed to stand overnight. The precipitate was filtered off to afford 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7-[5-(1-lambda/- methyl-imidazole)]-methylamide (454 mg, 66%).1H NMR (500 MHz, DMSO-d6): 9.15 (br. s., 1 H), 9.07 (br. s., 1 H), 8.61 (d, J = 7.25 Hz, 1 H), 8.25 (s, 1 H), 7.89 (s, 1 H), 7.77 (s, 1 H), 7.56 (s, 1 H), 7.39 – 7.52 (m, 3 H), 7.26 (d, J = 7.25 Hz, 1 H), 7.11 (br. s., 1 H), 6.87 (s, 1 H), 4.51 (s, 2 H), 3.93 (q, J = 9.77 Hz, 2 H), 3.64 (s, 3 H). MS: [M+H] +: 472.2 Melting point > 2600C
The synthetic route of 384821-19-6 has been constantly updated, and we look forward to future research findings.