Category: 378203-86-2

Adding a certain compound to certain chemical reactions, such as: 378203-86-2, name is Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 378203-86-2, HPLC of Formula: C7H9N3O4

Intermediate 44b) A degassed solution of intermediate 44a (480 mg), 2-bromo-1 ,4-dimethoxybenzene (1.04 g), palladium acetate (54 mg), di(1 -adamantyl)-n-butylphosphine (130 mg) and potassium acetate (490 mg) in N,N- dimethyl acetamide (7 mL) was stirred under an argon atmosphere at 150 C for 2 h. The volatiles were removed under reduced pressure and the residue was dissolved in water and was extracted with CH2CI2. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by column chromatography (Si02/ 50 g, Cy / 2-propanol) to yield the desired compound (31 % yield). LC-MS {Method 1): m/z [M+H]+ = 336.2 (MW calc. = 335.31 ); R, = 3.4 min

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; WACHTEN, Sebastian; KLESS, Achim; VOSS, Felix; RITTER, Stefanie; WO2014/108336; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 378203-86-2,Some common heterocyclic compound, 378203-86-2, name is Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C7H9N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A degassed solution of intermediate 44a (480 mg), 2-bromo-1,4-dimethoxybenzene (1.04 g), palladium acetate (54 mg), di(1-adamantyl)-n-butylphosphine (130 mg) and potassium acetate (490 mg) in N,N-dimethyl acetamide (7 mL) was stirred under an argon atmosphere at 150 C. for 2 h. The volatiles were removed under reduced pressure and the residue was dissolved in water and was extracted with CH2Cl2. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by column chromatography (SiO2/50 g, Cy/2-propanol) to yield the desired compound (31% yield). [0596] LC-MS (Method 1): m/z [M+H]+=336.2 (MW calc.=335.31); Rt=3.4 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, its application will become more common.

Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014/194452; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 378203-86-2, These common heterocyclic compound, 378203-86-2, name is Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 13 Ethyl 4-amino-i -methylpyrazole-3 -carboxylateTin(II) chloride dihydrate (7.42 g, 32.9 mmol) was added to a solution ofIntermediate 12 (i.3i g, 6.58 mmol) in EtOH (50 mL). The reaction was heated at 50Cwith stirring for 3.5 h, then cooled to room temperature and concentrated in vacuo. The residue was diluted with DCM and treated with 2M aqueous NaOH solution. A viscous thick precipitate formed. The mixture was filtered through celite, and the two layers were separated. The aqueous layer was extracted with DCM (twice). The combined organiclayers were passed through a phase separator cartridge, then evaporated. The resulting crude material was purified by silica gel chromatography (gradient 25-75% EtOAc in isohexane). The title compound (0.32 g, 29%) was isolated as a dark blue/black oil. oH (400 MHz, DMSO-d6) 7.i2 (s, iH), 4.66 (s, 2H), 4.23 (q, 2H,J7.i Hz), 3.76 (s, 3H), i.27 (t, 3H,J7.i Hz).

Statistics shows that Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 378203-86-2.

Reference:
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem