Category: 3724-19-4

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about A Novel and Rapid Encoding Method Based on Mass Spectrometry for “”One-Bead-One-Compound”” Small Molecule Combinatorial Libraries.Computed Properties of C8H9NO2.

A method for the preparation and encoding of readily deconvoluted combinatorial libraries is discussed. Beads are prepared with topol. segregated regions – an inner region to which is bound coding tags and an outer segment to which the library compound is bound. Coding blocks are attached to the inner resin by a cleavable methionine-containing linker; the coding blocks are chosen to have similar reactivities to the building blocks incorporated in the synthesis of the combinatorial library. Synthesis of the library leads to the functionalization of the library-containing portion of the resin bead and the coding portion of the resin bead. Cleavage of the linkers for the coding blocks from the resin bead by Edman degradation with cyanogen bromide yields lactones whose mass is determined by FT-MALDI mass spectroscopy. Anal. of the lactones isolated from a given bead yields the mass of each of the fragments present; by careful choice of coding blocks and reactants, the identities of the building blocks incorporated into a library bead and of the library member attached to that bead can be readily derived from the fragment masses. A combinatorial library is prepared and tested for the binding of library members to streptavidin; seventeen of the compounds are found to bind strongly to streptavidin by a colorometric assay and identified unambiguously by the library encoding method described here.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 3724-19-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Spacer-Directed Coordination Polymers-of-Oligomers (POLO) of Silver. Author is Teo, Peili; Koh, L. L.; Hor, T. S. Andy.

Ag(I) polymers-of-oligomers with pyridylcarboxylate spacers supported by a diphosphine [bis(diphenylphosphino)methane (dppm) or 1,1′-bis(diphenylphosphino)ferrocene (dppf)] were constructed and crystallog. established. The repeating oligomeric Ag5 block is invariably made up of five Ag(I) centers comprising Ag2 and Ag units with different metal geometries. Other related Ag5 and Ag4 assemblies also were isolated. The preparation of the [Ag2(isonic)(dppm)2]nn+ polymer (isonic = 4-pyridylformate, NC5H4CO2-) using a ligand transfer pathway from NiCl2(dppm) to AgOTf (OTf = CF3SO3-) was identified. The structural outcomes suggested that pyridylcarboxylates of different stereogeometrical and conformational properties can stabilize different oligomeric and topol. forms through adaptation to the contrasting demands of the diphosphine and metal.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3724-19-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Solid-phase photochemical decarboxylative hydroalkylation of peptides. Author is Elkhalifa, Mahmoud; Elbaum, Michael B.; Chenoweth, David M.; Molander, Gary A..

The compatibility of photochem. with solid-phase peptide synthesis is demonstrated via photochem. hydroalkylation to form C(sp3)-C(sp3) bonds between on-resin Giese acceptors and redox-active esters. Both iridium-based photocatalysts and Hantszch ester led to high yields, with final reaction conditions producing full conversions within 30 min under ambient conditions. The chem. is compatible with a broad range of peptide side chains, redox-active esters, and resin. These conditions represent the first example of photochem. peptide modifications on resin.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The synthesis of 1,6-naphthyridine》. Authors are Ferrier, B. M.; Campbell, Neil.The article about the compound:3-Pyridinepropionic acidcas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1).COA of Formula: C8H9NO2. Through the article, more information about this compound (cas:3724-19-4) is conveyed.

Reduction of 4.5 g. 3-pyridylacrylic acid (I) in 100 ml. water with 0.5 g. PtO2 by shaking in H 30 min., filtering, resuspending the insoluble portion in water and repeating the process until all insoluble I had disappeared, gave, on vacuum distillation of the combined water solutions, 2.92 g. 3-pyridylpropionic acid (II), cubes, m. 161-2° (EtOH). Under similar conditions reduction of I in one step until no more H was absorbed gave 3-piperidylpropionic acid, isolated as its hydrochloride (1.1 g.) from EtOH, prisms, m. 225°. II (1 g.) was heated 3 hrs. with 5 ml. 100-volume H2O2 and 25 ml. HOAc, the volume reduced to 10 ml. in vacuo, 25 ml. water added, and the process repeated until 0.8 g. 3-pyridylpropionic acid N-oxide (III) separated, prisms m. 144-53° (EtOH). III (0.5 g.), 10 ml. fuming HNO3, and 10 ml. H2SO4 were boiled 1 hr., poured on 50 ml. ice, the solution brought to pH 5 with NH4OH, and 0.36 g. 4-nitro-3-pyridylpropionic acid 1-oxide (IV), yellow plates, m. 169-71° (EtOH), extracted with EtOAc. IV (0.2 g.), 0.5 g. reduced Fe powder, and 6 ml. HOAc were heated 0.5 hr., poured into water, filtered, and the filtrate made alk. with NH4OH and extracted with EtOAc to give 0.05 g. 1,2,3,4-tetrahydro-2-oxo-1,6-naphthyridine, needles, m. 208° (C6H6). III (0.3 g.) in 5 ml. HCl was treated with 0.75 g. Zn dust until colorless, boiled with 0.25 g. more Zn for 2 min., made alk. with NH4OH, and the 1,2,3,4-tetrahydro-1,6-naphthyridine (V) which separated sublimed in vacuo and recrystallized to give 0.05 g. needles, m. 208°; picrate, orange-yellow prisms m. 175° (EtOH). Heating 0.03 g. V 2 hrs. at 220-30° with 0.025 g. 13.5% Pt/C gave, on EtOH extraction, an oil. The picrate of this oil (m. 211°) was dissolved in concentrated NH4OH, extracted with petr. ether, cooled, and after decanting an oil which separated, chilled in ice to give 3 mg. 1,6-naphthyridine, needles, m. 29-30°. 3-Ethylpyridine (3 g.) was oxidized and nitrated (as II above) to give 1.4 g. 3-ethyl-4-nitropyridine 1-oxide, yellow needles m. 63-4° (petr. ether), of which 0.38 g. was reduced (H, PtO2 in HOAc or Zn-HCl) to 4 mg. 4-amino-3-ethylpyridine, needles m. 42-3° (petr. ether); picrate m. 202-3°. Ultraviolet spectra were reported for the naphthyridines and compared with those of the corresponding pyridine derivatives

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Imidazole – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3724-19-4, is researched, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2Journal, Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov’t, Non-P.H.S., Journal of the American Chemical Society called Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids, Author is Kautzky, Jacob A.; Wang, Tao; Evans, Ryan W.; MacMillan, David W. C., the main research direction is iridium photoredox catalyzed decarboxylative trifluoromethylation aliphatic carboxylic acid.Recommanded Product: 3724-19-4.

Herein authors disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcs., and strained ring systems. To demonstrate the broad potential of this new methodol. for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogs.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 3724-19-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about A new method for the esterification of carboxylic acids with various alcohols by using di-2-thienyl carbonate, a new coupling reagent. Author is Mukaiyama, Teruaki; Oohashi, Yoshiaki; Fukumoto, Kentarou.

Esterification of carboxylic acids with alcs. by using di-2-thienyl carbonate in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) proceeded smoothly under mild conditions to afford the corresponding esters and 2(5H)-thiophenone in good to high yields.

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Imidazole – Wikipedia,
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Electric Literature of C8H9NO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Entropy, enthalpy, and side arm porphyrins. 1. Thermodynamics of axial ligand competition between 3-picoline and a series of 3-pyridyl ligands covalently attached to zinc tetraphenylporphyrin.

A series of 5-coordinate Zn tetraphenylporphyrins, each with a covalently attached 3-pyridyl side chain of different length, were prepared NMR spectroscopy was used to study the displacement of the 3-pyridyl ligand by free 3-picoline in toluene-d8 solution Values of Keq, ΔH, and ΔS were dependent on the number of atoms in the chain. In all cases, 3-picoline formed a stronger bond with these Zn porphyrins than did the covalently attached pyridyl ligands. The entropy of free internal rotation of the atoms of the uncoordinated pyridyl side chain was an important factor in the entropy of displacement of the covalently attached pyridyl group. Measurement of the thermodn. quantities for 3-picoline addition to a series of structurally related 4-coordinate Zn porphyrins revealed the importance of bulky groups in preventing tight solvation of the porphyrin ring in the region of the binding site, thus increasing the stability and bond strength of the 3-picoline complex.

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Tan, Wen-Yun; Lu, Yi; Zhao, Jing-Feng; Chen, Wen; Zhang, Hongbin published an article about the compound: 3-Pyridinepropionic acid( cas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1 ).Reference of 3-Pyridinepropionic acid. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3724-19-4) through the article.

In this paper,a new chemoselective process for the oxidation of primary alcs. and aldehydes was reported. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcs. and tert-butanesulfinamides.

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Imidazole – Wikipedia,
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Related Products of 3724-19-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity. Author is Reddy, K. Papi; Bid, Hemant K.; Nayak, V. Lakshma; Chaudhary, Preeti; Chaturvedi, J. P.; Arya, K. R.; Konwar, Rituraj; Narender, T..

The taxane diterpenoid 2-deacetoxytaxinine J (2-DAT-J; I) has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J showed significant in vitro activity against breast cancer cell line at a concentration of 20 μM and 10 μM in MCF-7 and MDA-MB-231 resp. A few novel taxoids were derived from the naturally occurring 2-DAT-J and screened for their anticancer activity. The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10 mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p < 0.05). Here is a brief introduction to this compound(3724-19-4)Related Products of 3724-19-4, if you want to know about other compounds related to this compound(3724-19-4), you can read my other articles.

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Imidazole – Wikipedia,
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Related Products of 3724-19-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Relationship between Chemical Structure and Supramolecular Effective Molarity for Formation of Intramolecular H-Bonds. Author is Sun, Hongmei; Hunter, Christopher A.; Navarro, Cristina; Turega, Simon.

Effective molarity (EM) is a key parameter that determines the efficiency of a range of supramol. phenomena from the folding of macromols. to multivalent ligand binding. Coordination complexes formed between zinc porphyrins equipped H-bond donor sites and pyridine ligands equipped with H-bond acceptor sites have allowed systematic quantification of EM values for the formation of intramol. H-bonds in 240 different systems. The results provide insights into the relationship of EM to supramol. architecture, H-bond strength, and solvent. Previous studies on ligands equipped with phosphonate diester and ether H-bond acceptors were inconclusive, but the experiments described here on ligands equipped with phosphine oxide, amide, and ester H-bond acceptors resolve these ambiguities. Chem. double-mutant cycles were used to dissect the thermodn. contributions of individual H-bond interactions to the overall stabilities of the complexes and hence determine the values of EM, which fall in the range 1-1000 mM. Solvent has little effect on EM, and the values measured in toluene and 1,1,2,2-tetrachloroethane are similar. For H-bond acceptors that have similar geometries but different H-bond strengths (amide and ester), the values of EM are very similar. For H-bond acceptors that have different geometries but similar H-bond strengths (amide and phosphonate diester), there is little correlation between the values of EM. These results imply that supramol. EMs are independent of solvent and intrinsic H-bond strength but depend on supramol. architecture and geometric complementarity.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem