Category: 3724-19-4

Computed Properties of C8H9NO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Highly efficient N-heterocyclic carbene/ruthenium catalytic systems for the acceptorless dehydrogenation of alcohols to carboxylic acids: effects of ancillary and additional ligands. Author is Wang, Wan-Qiang; Cheng, Hua; Yuan, Ye; He, Yu-Qing; Wang, Hua-Jing; Wang, Zhi-Qin; Sang, Wei; Chen, Cheng; Verpoort, Francis.

The transition-metal-catalyzed alc. dehydrogenation to carboxylic acids has been identified as an atom-economical and attractive process. Among various catalytic systems, Ru-based systems have been the most accessed and investigated ones. With our growing interest in the discovery of new Ru catalysts comprising N-heterocyclic carbene (NHC) ligands for the dehydrogenative reactions of alcs., we designed and prepared five NHC/Ru complexes ([Ru]-1-[Ru]-5) bearing different ancillary NHC ligands. Moreover, the effects of ancillary and addnl. ligands on the alc. dehydrogenation with KOH were thoroughly explored, followed by the screening of other parameters. Accordingly, a highly active catalytic system, which is composed of [Ru]-5 combined with an addnl. NHC precursor L5, was discovered, affording a variety of acid products in a highly efficient manner. Gratifyingly, an extremely low Ru loading (125 ppm) and the maximum TOF value until now (4800) were obtained.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Computed Properties of C8H9NO2, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

SDS of cas: 3724-19-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Experimental spectroscopic, Quantum computational, Hirshfeld surface and molecular docking studies on 3-Pyridinepropionic acid. Author is Savita, Sandhya; Fatima, Aysha; Garima, Km.; Pooja, Km.; Verma, Indresh; Siddiqui, Nazia; Javed, Saleem.

3-Pyridine propionic acid (3-PPIA) was studied exptl. by UV-Vis, 1H NMR, 13C NMR spectroscopy and Quantum computationally by d. functional theory approach. The B3LYP/6-311++G(d,p) basis set used to get the optimized structure, vibrational frequencies, and other various parameters. Calculated bond lengths and angles were compared with the exptl. bond lengths and Bond angle Parameters. 3D Hirshfeld surface and 2D fingerprint plots were drawn by using Crystal Explorer software. The HOMO/LUMO energy gap results indicated that, adequate charge transfer was happening within the mol. ELF was drawn to find the degree of relative localization of electrons. The NBO anal. was done to study donor and acceptor interactions. The MEP surface was drawn in 3-D color coding and Fukui functions were analyzed to find possible sites to attack by different substituents. TD-DFT method and PCM solvent model was employed for electronic property anal. such as UV-Vis (in gas phase, ethanol and DMSO) and compared with the exptl. UV-Vis spectra done in DMSO and Methanol. 2D Hirshfeld surface was drawn to study intermol. interactions in detail and 2D finger print plots were drawn for anal. of percentage of interaction in between atoms, it revealed that 3-PPIA was stabilized mainly by formation of H-H/H-O/C-H contacts. The drug-likeness study was carried out on the ligand mol. and its derivatives, indicated drug like nature of 3-PPIA. Mol. docking was done to study interaction between ligand and proteins with two protein receptors 4JIR and 5OUO, and found binding energies-6.6 and -6.2 kcal/mol, showed to have potential application in the medical field. This study could be used in the future for further development of pharmacol. active based on 3-pyridinepropionic acid.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)SDS of cas: 3724-19-4, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3724-19-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Discovery of Selective Hexapeptide Agonists to Human Neuromedin U Receptors Types 1 and 2. Author is Takayama, Kentaro; Mori, Kenji; Taketa, Koji; Taguchi, Akihiro; Yakushiji, Fumika; Minamino, Naoto; Miyazato, Mikiya; Kangawa, Kenji; Hayashi, Yoshio.

Neuromedin U (NMU) are bioactive peptides with a common C-terminal heptapeptide sequence (FLFRPRN-amide, 1a) among mammals, which is responsible for receptor activation, namely NMU receptor types 1 (NMUR1) and 2 (NMUR2). Among the various physiol. actions of NMU, the anorexigenic effect has recently attracted attention in drug discovery efforts for treating obesity. Although several structure-activity relationship (SAR) studies have been reported, receptor-selective small peptide agonists have yet to be disclosed. Herein a SAR study of 1a-derived peptide derivatives is described. We initially screened both human NMUR1- and NMUR2-selective peptides in calcium-mobilization assays with cells transiently expressing receptors. Then we performed a precise assay with a stable expression system of receptors and consequently discovered hexapeptides 8d and 6b possessing selective agonist activity toward each resp. receptor. Hexapeptide 6b, which selectively activates NMUR2 without significant NMUR1 activation, should aid in the development of anorexigenic drugs as well as advance NMU-related endocrinol. research.

From this literature《Discovery of Selective Hexapeptide Agonists to Human Neuromedin U Receptors Types 1 and 2》,we know some information about this compound(3724-19-4)Application of 3724-19-4, but this is not all information, there are many literatures related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Influence of nicotinic acid and its derivatives on the enzymic acetylation of p-aminobenzoic acid in vitro, the main research direction is LIVER; NICOTINAMIDE; NICOTINIC ACID; PARA-AMINOBENZOIC ACID; PYRIDINES.Recommanded Product: 3724-19-4.

The influence of nicotinic acid, nicotinamide, 3-pyridylacetic acid (I), 3-pyridylacetamide, 3-pyridylacrylic acid (II), 3-pyridylacrylamide, and 3-pyridylpropionic acid (III) on the acetylation of p-aminobenzoic acid was investigated. Aside from nicotinic acid and I, all compounds had inhibitive action. A relation seemed to exist between inhibition and length of side chains in the case of acids. Most active were II and III. The amides were more active than their acids.

From this literature《Influence of nicotinic acid and its derivatives on the enzymic acetylation of p-aminobenzoic acid in vitro》,we know some information about this compound(3724-19-4)Recommanded Product: 3724-19-4, but this is not all information, there are many literatures related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Effect of nicotinic acid and nicotinic acid homologs on lipolysis, phosphodiesterase activity, adenyl cyclase activity, and cyclic AMP synthesis in fat cells, the main research direction is nicotinic acid derivative lipolysis; pyridylacetic acid lipolysis.Recommanded Product: 3-Pyridinepropionic acid.

Nicotinic acid (I) [59-67-6], 3-pyridylacetic acid [501-81-5], and to a lesser extent ω-(3-pyridyl)acrylic acid [1126-74-5], inhibited lipolysis, adenyl cyclase activity, and cyclic AMP synthesis in adipose tissue preparations ω-(3-Pyridyl) propionic acid [3724-19-4], ω-(3-pyridyl)butyric acid [17270-50-7], and ω-(3-pyridyl)valeric acid [36599-14-1] had no activity in these tests. None of the compounds tested affected phosphodiesterase activity. The data suggest that the antilipolytic activity of nicotinic acid and 3-pyridylacetic acid is mediated via inhibition of cyclic AMP synthesis.

From this literature《Effect of nicotinic acid and nicotinic acid homologs on lipolysis, phosphodiesterase activity, adenyl cyclase activity, and cyclic AMP synthesis in fat cells》,we know some information about this compound(3724-19-4)Recommanded Product: 3-Pyridinepropionic acid, but this is not all information, there are many literatures related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Computed Properties of C8H9NO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about 3-(Pyridin-3-yl)propionic acid. Author is Lemmerer, Andreas.

In the crystal of the title compound, C8H9NO2, mols. assemble to form C(8) chains along the b axis by N-H…O H bonds, supported by weaker C-H…O H bonded-interactions between adjacent chains. Crystallog. data and at. coordinates are given.

From this literature《3-(Pyridin-3-yl)propionic acid》,we know some information about this compound(3724-19-4)Computed Properties of C8H9NO2, but this is not all information, there are many literatures related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3724-19-4, is researched, Molecular C8H9NO2, about Discovery of selective fragment-sized immunoproteasome inhibitors, the main research direction is immunoproteasome inhibitor benzooxazolethione benzothiazolethione benzimidazolethione chymotrypsin subunit binding SAR; Chloro scan; Disulfide formation; Electrophilic warheads; Fragments; Immunoproteasome; Thiones.Synthetic Route of C8H9NO2.

Proteasomes contribute to maintaining protein homeostasis and their inhibition is beneficial in certain types of cancer and in autoimmune diseases. However, the inhibition of the proteasomes in healthy cells leads to unwanted side-effects and significant effort has been made to identify inhibitors specific for the immunoproteasome, especially to treat diseases which manifest increased levels and activity of this proteasome isoform. Here, we report our efforts to discover fragment-sized inhibitors of the human immunoproteasome. The screening of an inhouse library of structurally diverse fragments resulted in the identification of benzo[d]oxazole-2(3H)-thiones, benzo[d]thiazole-2(3H)-thiones, benzo[d]imidazole-2(3H)-thiones, and 1-methylbenzo[d]imidazole-2(3H)-thiones (with a general term benzoXazole-2(3H)-thiones) as inhibitors of the chymotrypsin-like (β5i) subunit of the immunoproteasome. A subsequent structure-activity relationship study provided us with an insight regarding growing vectors. Binding to the β5i subunit was shown and selectivity against the β5 subunit of the constitutive proteasome was determined Thorough characterization of these compounds suggested that they inhibit the immunoproteasome by forming a disulfide bond with the Cys48 available specifically in the β5i active site. To obtain fragments with biol. more tractable covalent interactions, we performed a warhead scan, which yielded benzoXazole-2-carbonitriles as promising starting points for the development of selective immunoproteasome inhibitors with non-peptidic scaffolds.

If you want to learn more about this compound(3-Pyridinepropionic acid)Synthetic Route of C8H9NO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

SDS of cas: 3724-19-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Enhanced photocatalytic hydrogen production by introducing the carboxylic acid group into cobaloxime catalysts. Author is Wang, Junfei; Li, Chao; Zhou, Qianxiong; Wang, Weibo; Hou, Yuanjun; Zhang, Baowen; Wang, Xuesong.

A series of cobaloxime complexes, [Co(III)(dmgH)2(py-m-X)Cl] (dmgH = dimethylglyoxime, py-m-X = meta-substituted pyridine, X = COOH (2), COOCH3 (3), CH2CH2COOH (6), and CH2CH2COOCH3 (7)), and [Co(III)(dmgH)2(py-p-X)Cl], (py-p-X = para-substituted pyridine, X = COOH (4) and COOCH3 (5)), were synthesized and their photocatalytic H2 production activities were compared in an artificial photosynthesis system containing a xanthene dye Eosin Y as the photosensitizer (PS) and triethanolamine (TEOA) as the sacrificial reductant (SR) in CH3CN/H2O (1:1, pH = 7.5). Irresp. of substitution by an electron-donating or electron withdrawing group, the photocatalytic H2 production activities of 2-7 are all higher than that of [Co(III)(dmgH)2(py)Cl] (1). Importantly, meta-substitution is more efficient than para-substitution, and COOH is more efficient than COOCH3, in enhancing the photocatalytic activities. 6 showed the highest activity among the examined complexes. The -CH2CH2- chain linking COOH and pyridine might play a role in the promising performance of 6, which makes the proton relay via interaction between COOH and dmgH possible. This work may open new avenues for developing more efficient cobaloxime-based H2 evolution catalysts (HERs).

If you want to learn more about this compound(3-Pyridinepropionic acid)SDS of cas: 3724-19-4, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3724-19-4).

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Name: 3-Pyridinepropionic acid. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Immobilization of a high-valent rhenium complex on an indium-doped tin-oxide electrode: Enhanced catalytic activity of a trans-dioxorhenium(V) complex in electrochemical oxidation of alcohols. Author is Sugimoto, Hideki; Tsukube, Hiroshi; Tanaka, Koji.

A high-valent trans-dioxorhenium(V) complex containing pyridine ligands was successfully immobilized on an ITO (indium-doped tin-oxide) electrode. The complex formed a monolayer structure on the electrode surface and promoted electrochem. catalytic oxidation of 1-phenylethanol to acetophenone in CH2Cl2. Oxidation hardly occurred in CH2Cl2 solution containing the free rhenium(V) complex. Immobilization of other high-valent metal complexes will present opportunities for design of functional electrodes with high activities.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Name: 3-Pyridinepropionic acid, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.Application In Synthesis of Bis(2-(Di(adamantan-1-yl)phosphino)ethyl)amine. The article 《Varying the metal to ethacrynic acid ratio in ruthenium(II)/osmium(II)-p-cymene conjugates》 in relation to this compound, is published in Journal of Inorganic Biochemistry. Let’s take a look at the latest research on this compound (cas:3724-19-4).

Following the identification of a ruthenium(II)-arene complex with an ethacrynic acid-modified imidazole ligand, which inhibits glutathione transferase (GST) and is cytotoxic to chemo-resistant cancer cells, a series of structurally related ruthenium(II)- and osmium(II)-p-cymene compounds have been prepared In these complexes the ethacrynic acid is linked to the metals via appropriately modified pyridine ligands. The influence of the metal center and the metal:ethacrynic acid ratio on the cytotoxicity of the compounds was evaluated with the derivatives with one metal center and two ethacrynic acid moieties being the most potent against chemo-resistant A2780cisR cells (human ovarian cancer cells with acquired resistance to cisplatin). Moreover, compared to a complex with an ethacrynic acid-modified imidazole ligand (RAIMID-EA), these complexes display a significant degree of cancer cell specificity.

There is still a lot of research devoted to this compound(SMILES：OC(=O)CCC1=CC=CN=C1)Formula: C8H9NO2, and with the development of science, more effects of this compound(3724-19-4) can be discovered.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem