Category: 3724-19-4

Recommanded Product: 3724-19-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Fluorescence enhancement by chelation of Eu3+ and Tb3+ ions in sol-gels. Author is Magyar, A. P.; Silversmith, A. J.; Brewer, K. S.; Boye, D. M..

Chelation of rare-earth (RE) ions is investigated as a means of enhancing the optical properties of RE-doped silica sol-gels. Two chelating agents [2,6-pyridine-dicarboxylic acid (PDC) and 3-pyridinepropionic acid (PPA)] and two different synthesis techniques are studied. Eu(PDC) gels exhibit intense 5D0 → 7F2 fluorescence in the red under UV excitation and long fluorescence lifetimes compared to Eu(PPA) gels and to gels without a chelating agent. This behavior indicates that the PDC mol. remains associated with the Eu after incorporation into the gel. Similar behavior is seen for 5D4 → 7F5 green fluorescence in Tb(PDC).

《Fluorescence enhancement by chelation of Eu3+ and Tb3+ ions in sol-gels》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(3-Pyridinepropionic acid)Recommanded Product: 3724-19-4.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Influence of nicotinic acid homologs on oxidation of cholesterol-26-C14 by rat liver mitochondria》. Authors are Kritchevsky, David; Tepper, Shirley A..The article about the compound:3-Pyridinepropionic acidcas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1).COA of Formula: C8H9NO2. Through the article, more information about this compound (cas:3724-19-4) is conveyed.

Nicotinic acid (I) and its homolog 3-pyridylacetic acid (II) have been reported to act as hypocholesterolemic agents. I, II, and propionic (III), butyric (IV), and valeric (V) acids with ω-(3-pyridyl) substitutions, all in 8 × 10-5M concentrations were incubated for 18 hrs. in a solution (composition given) containing cholesterol-26-C14 (VI) plus a soluble cofactor and other constituents. The percentage oxidation of the VI was calculated from the C14O2 evolved by the action of rat liver mitochondria suspended in the solution Quant. data are tabulated. Some oxidation of VI occurred in the absence of I and similar compounds The I increased the oxidation of VI to a significant extent when average values for 8 experiments were determined although the results in individual experiments showed considerable variation. II was nearly as active as I in promoting the oxidation When average effects were calculated, III and V depressed the oxidation while IV had no effect. I diminishes cholesterol in the blood probably by increased oxidation together with alterations in lipid synthesis. ` For experiments in vitro, the effects of II and its higher homologs probably result from a direct oxidation of cholesterol and are not secondary to other metabolic actions of mitochondria.

The article 《Influence of nicotinic acid homologs on oxidation of cholesterol-26-C14 by rat liver mitochondria》 also mentions many details about this compound(3724-19-4)COA of Formula: C8H9NO2, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Effects of nicotinic acid and some of its homologs on lipolysis, adenyl cyclase, phosphodiesterase, and cyclic AMP accumulation in isolated fat cells, the main research direction is nicotinic acid lipolysis; pyridylacetic acid cyclic AMP; antilipolytic nicotinic analog.HPLC of Formula: 3724-19-4.

Nicotinic acid (I) [59-67-6] (10-6 to 10-4M), 3-pyridylacetic acid [501-81-5] (10-6 to 10-4M), and to a lesser extent ω-(3-pyridyl)acrylic acid [1126-74-5], decreased lipolysis, adenyl cyclase [9012-42-4] activity, and cyclic AMP [60-92-4] synthesis in isolated male rat fat cells. None of the compounds tested affected phosphodiesterase [9025-82-5] activity. These antilipolytic compounds may mediate their effects by inhibiting cyclic AMP synthesis.

The article 《Effects of nicotinic acid and some of its homologs on lipolysis, adenyl cyclase, phosphodiesterase, and cyclic AMP accumulation in isolated fat cells》 also mentions many details about this compound(3724-19-4)HPLC of Formula: 3724-19-4, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 3724-19-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Effect of β-(3-pyridyl)propionic and β-(3-pyridyl)acrylic acids on the respiration of Sinapis alba roots.

β-(3-Pyridyl)propionic acid (I) and trans-β-(3-pyridyl)acrylic acid (II) retarded the growth of roots and hypocotyls and decreased the in vivo and in vitro enzymic activity of succinate dehydrogenase (III) in S. alba, but had little effect on cytochrome oxidase activity. II was approx. 2-fold more potent than I in reducing III, apparently because of the styrylpyridine moiety in II.

The article 《Effect of β-(3-pyridyl)propionic and β-(3-pyridyl)acrylic acids on the respiration of Sinapis alba roots》 also mentions many details about this compound(3724-19-4)HPLC of Formula: 3724-19-4, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Chromatography A called Preparative-scale isoelectric trapping separations in methanol-water mixtures, Author is Shave, Evan; Vigh, Gyula, which mentions a compound: 3724-19-4, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2, Quality Control of 3-Pyridinepropionic acid.

The typically low aqueous solubilities of small, hydrophobic organic ampholytic mols. limit the production rates that can be achieved in their isoelec. trapping (IET) separations and call for the use of hydro-organic mixtures as solvents. The compatibility of methanol-water mixtures and poly(ethylene terephthalate) substrate-supported isoelec. polyacrylamide hydrogels, developed for binary IET separations in a Gradiflow BF200IET unit, was studied. The isoelec. polyacrylamide-based hydrogels retained their functional and mech. integrities when the methanol concentration in the hydro-organic solvent mixture was kept at or <25% (volume/volume). The utility of the hydro-organic media was demonstrated in the purification of a hydrophobic ampholytic compound, tech. grade 4-hydroxy-3-(morpholinomethyl) benzoic acid. Production rates ≤7 mg/h were achieved using small, 15 cm2 active surface area isoelec. membranes. The article 《Preparative-scale isoelectric trapping separations in methanol-water mixtures》 also mentions many details about this compound(3724-19-4)Quality Control of 3-Pyridinepropionic acid, you can pay attention to it, because details determine success or failure

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Jiang, Min; Peng, Lei; Yang, Kai; Wang, Tianqi; Yan, Xueming; Jiang, Tao; Xu, Jianrong; Qi, Jin; Zhou, Hanbing; Qian, Niandong; Zhou, Qi; Chen, Bo; Xu, Xing; Deng, Lianfu; Yang, Chunhao researched the compound: 3-Pyridinepropionic acid( cas:3724-19-4 ).Quality Control of 3-Pyridinepropionic acid.They published the article 《Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization》 about this compound( cas:3724-19-4 ) in Journal of Medicinal Chemistry. Keywords: propanamide synthesis SAR RANKL RANK bone resorption osteoclastogenesis. We’ll tell you more about this compound (cas:3724-19-4).

Targeting RANKL/RANK offers the possibility of developing novel therapeutic approaches to treat bone metabolic diseases. Multiple efforts have been made to inhibit RANKL. For example, marketed monoclonal antibody drug Denosumab could inhibit the maturation of osteoclasts by binding to RANKL. This study is an original approach aimed at discovering small-mol. inhibitors impeding RANKL/RANK protein interaction. We identified compound 34 as a potent and selective RANKL/RANK inhibitor by performing structure-based virtual screening and hit optimization. Disruption of the RANKL/RANK interaction by 34 effectively inhibits RANKL-induced osteoclastogenesis and bone resorption. The expression of osteoclast marker genes was also suppressed by treatment of 34. Furthermore, 34 markedly blocked the NFATc1/c-fos pathway. Thus, our current work demonstrates that the chem. tractability of the difficult PPI (RANKL/RANK) target by a small-mol. compound 34 offers a potential lead compound to facilitate the development of new medications for bone-related diseases.

After consulting a lot of data, we found that this compound(3724-19-4)Quality Control of 3-Pyridinepropionic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Heterodinuclear Pt(IV)-Ru(II) anticancer prodrugs to combat both drug resistance and tumor metastasis.Name: 3-Pyridinepropionic acid.

A novel approach to design bimetallic anticancer drug candidates with the capability to combat both drug resistance and tumor metastasis is reported. These water-soluble bifunctional Pt(IV)-Ru(II) heterodinuclear ruthplatin complexes with a unique mode of action display up to 2-orders of magnitude enhanced cytotoxicity in cisplatin-resistant cells and significantly impede cancer cell migration.

Although many compounds look similar to this compound(3724-19-4)Name: 3-Pyridinepropionic acid, numerous studies have shown that this compound(SMILES:OC(=O)CCC1=CC=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Pyridinepropionic acid( cas:3724-19-4 ) is researched.Category: imidazoles-derivatives.Bay, Anna V.; Fitzpatrick, Keegan P.; Gonzalez-Montiel, Gisela A.; Farah, Abdikani Omar; Cheong, Paul Ha-Yeon; Scheidt, Karl A. published the article 《Light-Driven Carbene Catalysis for the Synthesis of Aliphatic and α-Amino Ketones》 about this compound( cas:3724-19-4 ) in Angewandte Chemie, International Edition. Keywords: aliphatic amino ketone preparation; acyl imidazole amino acid benzyl Hantzsch ester benzylation; carbene; catalysis; density functional theory; late-stage functionalization; photochemistry. Let’s learn more about this compound (cas:3724-19-4).

Single-electron N-heterocyclic carbene (NHC) catalysis has gained attention recently for the synthesis of C-C bonds. Guided by d. functional theory and mechanistic analyses, authors report the light-driven synthesis of aliphatic and α-amino ketones using single-electron NHC operators. Computational and exptl. results reveal that the reactivity of the key radical intermediate is substrate-dependent and can be modulated through steric and electronic parameters of the NHC. Catalyst potential is harnessed in the visible-light driven generation of an acyl azolium radical species that underwent selective coupling with various radical partners to afford diverse ketone products. This methodol. is showcased in the direct late-stage functionalization of amino acids and pharmaceutical compounds, highlighting the utility of single-electron NHC operators.

Compounds in my other articles are similar to this one(3-Pyridinepropionic acid)Category: imidazoles-derivatives, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.Application of 3724-19-4.

In Ig light chain (LC) amyloidosis, the misfolding, or misfolding and misassembly of LC a protein or fragments thereof resulting from aberrant endoproteolysis, causes organ damage to patients. A small mol. “”kinetic stabilizer”” drug could slow or stop these processes and improve prognosis. We previously identified coumarin-based kinetic stabilizers of LCs that can be divided into four components, including a “”linker module”” and “”distal substructure””. Our prior studies focused on characterizing carbamate, hydantoin, and spirocyclic urea linker modules, which bind in a solvent-exposed site at the VL-VL domain interface of the LC dimer. Here, we report structure-activity relationship data on 7-diethylamino coumarin-based kinetic stabilizers. This substructure occupies the previously characterized “”anchor cavity”” and the “”aromatic slit””. The potencies of amide and urea linker modules terminating in a variety of distal substructures attached at the 3-position of this coumarin ring were assessed. Surprisingly, crystallog. data on a 7-diethylamino coumarin-based kinetic stabilizer reveals that the urea linker module and distal substructure attached at the 3-position bind a solvent-exposed region of the full-length LC dimer distinct from previously characterized sites. Our results further elaborate the small-mol. binding surface of LCs that could be occupied by potent and selective LC kinetic stabilizers.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Science (Washington, DC, United States) called A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents, Author is Qin, Tian; Cornella, Josep; Li, Chao; Malins, Lara R.; Edwards, Jacob T.; Kawamura, Shuhei; Maxwell, Brad D.; Eastgate, Martin D.; Baran, Phil S., which mentions a compound: 3724-19-4, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2, Application In Synthesis of 3-Pyridinepropionic acid.

N-Hydroxytetrachlorophthalimide esters of carboxylic acids such as I (Ts = 4-MeC6H4SO2) underwent chemoselective coupling reactions with alkylzinc reagents such as R2Zn [R = Me, [13C]Me, Et, Bu, Me(CH2)8, H2C:CH(CH2)n, cyclohexylmethyl, Ph(CH2)5, MeCCCH2CH2, Me3SiCC(CH2)3, Cl(CH2)4, PhCH2O(CH2)3, TBDMSO(CH2)3, 2-(1,3-dioxan-2-yl)ethyl] (purchased or generated in situ) in the presence of NiCl2(MeOCH2CH2OMe) [NiCl2(glyme)] to yield decarboxylated coupling products such as II [R = Me, [13C]Me, Et, Bu, Me(CH2)8, H2C:CH(CH2)n, cyclohexylmethyl, Ph(CH2)5, MeCCCH2CH2, Me3SiCC(CH2)3, Cl(CH2)4, PhCH2O(CH2)3, TBDMSO(CH2)3, 2-(1,3-dioxan-2-yl)ethyl], allowing activated alkylcarboxylic acids to be used chemoselectively in coupling reactions instead of their parent alkyl derivatives The method was also used in conjunction with solid-phase peptide synthesis to yield peptides with novel side chains through activation of aspartate, glutamate, and proline γ-amides of glutamate residues. N-Hydroxyphthalimide esters of tertiary alkyl carboxylic acids such as pivalic acid underwent conjunctive coupling and decarboxylation reactions with the activated Knochel zinc reagent PhZnCl·LiCl (generated in situ from PhBr) and benzyl acrylate in the presence of NiCl2(glyme) to give benzyl α-phenyl-β-tert-alkyl carboxylates such as t-BuCH2CHPhCO2CH2Ph.

Although many compounds look similar to this compound(3724-19-4)Application In Synthesis of 3-Pyridinepropionic acid, numerous studies have shown that this compound(SMILES:OC(=O)CCC1=CC=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem