Category: 36947-69-0

Takahashi, Shogo; Togo, Hideo published the artcile< Efficient preparation of 2-imidazolines from aldehydes and ethylenediamines with 1,3-diiodo-5,5-dimethylhydantoin>, Application In Synthesis of 36947-69-0, the main research area is aldehyde ethylenediamine cyclization iodohydantoin; imidazoline preparation.

Various 2-imidazolines were prepared in high yields by reacting aldehydes and ethylenediamines with 1,3-diiodo-5,5-dimethylhydantoin. Moreover, chiral 1,3-diimidazolin-2-ylbenzene and 2,6-diimidazolin-2-ylpyridines, which function as a chiral ligand, could be directly obtained from corresponding dialdehydes in high yields.

Heterocycles published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Application In Synthesis of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kunz, Peter C.; Thiel, Indre; Noffke, Anna Louisa; Reiss, Guido J.; Mohr, Fabian; Spingler, Bernhard published the artcile< Ruthenium piano-stool complexes bearing imidazole-based PN ligands>, Electric Literature of 36947-69-0, the main research area is crystal structure imidazolylphosphine ruthenium half sandwich preparation catalyst hydration; mol structure imidazolylphosphine ruthenium half sandwich preparation catalyst hydration; imidazole imidazolylphosphine ruthenium preparation phosphorus NMR structure; alkyne hydration catalyst imidazolylphosphine ruthenium half sandwich.

A variety of piano-stool complexes of cyclopentadienyl Ru(II) with imidazole-based PN ligands were synthesized starting from the precursor complexes [CpRu(C10H8)]PF6, [CpRu(NCMe)3]PF6 and [CpRu(PPh3)2Cl]. PN ligands used are imidazol-2-yl, -4-yl and -5-yl phosphines. Depending on the ligand and precursor different types of coordination modes were observed; in the case of polyimidazolyl PN ligands these were κ1P-monodentate, κ2P,N-, κ2N,N- and κ3N,N,N-chelating and μ-κP:κ2N,N-bridging. The solid-state structures of [CpRu(1a)2Cl]·H2O (5·H2O, 1a = imidazol-2-yldiphenylphosphine), [{CpRu(μ-κP:κ2N,N-2b)}2](C6H5PO3H)2(C6H5PO3H2)2 (2b = bis(1-methylimidazol-2-yl)phenylphosphine), a hydrolysis product of the as well determined [{CpRu(μ-κP:κ2N,N-2b)}2](PF6)2·2MeCN (7b·2MeCN), [CpRu(κ1P-3a)(PPh3)]Cl·CH2Cl2 (9·CH2Cl2, 3a = tris(imidazol-2-yl)phosphine) and [CpRu(PPh3)2Cl]·CHCl3 were determined Furthermore, [CpRu(L)2]PF6 (L = imidazol-2-yl or imidazol-4-yl phosphine) were screened for their catalytic activity in the hydration of 1-octyne.

Journal of Organometallic Chemistry published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Electric Literature of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kunz, Peter C.; Klaeui, Wolfgang published the artcile< Zinc and cobalt(II) complexes of tripodal nitrogen ligands of the tris[2-substituted imidazol-4(5)-yl]-phosphane type. Biomimetic hydrolysis of an activated ester>, Category: imidazoles-derivatives, the main research area is tris imidazolyl phosphine ligand preparation zinc cobalt complexation; biomimetic ester hydrolysis zinc enzyme; nitrophenyl pyridine carboxylate hydrolysis kinetics zinc cobalt imidazolylphosphine catalyzed.

Novel tris[2-substituted imidazol-4(5)-yl]phosphane (4-TIPR) ligands 2b (R = Ph) and 2c (R = tBu) were prepared as model ligands for the tris(histidine) motif found in many zinc enzymes. They readily form cobalt and zinc nitrato and chloro complexes in protic solvents. The steric requirements of the substituents R in 4(5)-position of the 4-TIPR ligands (R = iPr (2a), Ph (2b), tBu (2c)) is discussed on the basis of their UV/VIS spectra. Zinc complexes of 2a and 2c were studied due to their ability to promote the hydrolysis of the activated ester 4-nitrophenyl pyridine-2-carboxylate (pNpic).

Collection of Czechoslovak Chemical Communications published new progress about Enzymes Role: BCP (Biochemical Process), BIOL (Biological Study), PROC (Process) (model). 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kang, Ying; Li, Yulan; Xu, Ying; Ji, Zhizhong published the artcile< Studies on synthesis of 2-(4-methoxybenzylidene)-5-aminomethylcyclopentanone derivatives and their antiinflammatory activity>, Recommanded Product: 2-(tert-Butyl)-1H-imidazole, the main research area is cyclopentanone methoxybenzylidene antiinflammatory preparation.

The synthesis of 2-(4-methoxybenzylidene)-5-aminomethylcyclopentanone derivatives and their antiinflammatory activities were studied. Ten new derivatives of 2-(4-methoxybenzylidene)-5-aminomethylcyclopentanonee were prepared The structures of these compounds were confirmed by spectral methods and their antiinflammatory activities were examined by carrageenin-induced rat paw edema test. The amino exchange was an elimination-addition reaction.

Journal of Chinese Pharmaceutical Sciences published new progress about Anti-inflammatory agents. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Recommanded Product: 2-(tert-Butyl)-1H-imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bertini, Franco; Galli, Remo; Minisci, Francesco; Porta, Ombretta published the artcile< Free radical reactivity of the imidazole ring>, Reference of 36947-69-0, the main research area is imidazole alkylation; benzimidazole alkylation; free radial alkylation; imidazole carbamoylation.

Treating imidazole (I, R = H) by an aqueous Ag-catalyzed peroxydisulfate-decarboxylation of carboxylic acids gave 80-8% I (R = iso-Pr, tert-Bu). Similarly prepared were 50-93% II (R = Pr, iso-Pr, tert-Bu, cyclohexyl, PhOCH2) and 78% III (R = iso-Pr). II (R = H) with HCONH2 and aqueous tert-BuOOH-Fe2+ gave 60% II (R = CONH2).

Chimica e l’Industria (Milan, Italy) published new progress about Alkylation. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Reference of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dong, Jianghong; Chen, Shengwei; Li, Runfeng; Cui, Wei; Jiang, Haiming; Ling, Yixia; Yang, Zifeng; Hu, Wenhui published the artcile< Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus>, Related Products of 36947-69-0, the main research area is imidazole pinanamine antiviral influenza virus; Dual inhibitory activity; Influenza A virus; M2 ion channel; Pinanamine derivatives.

The authors previously reported potent hit compound (I) inhibiting the wild-type influenza A virus A/HK/68 (H3N2) and A/M2-S31N mutant viruses A/WS/33 (H1N1), with its latter activity quite weak. To further increase its potency, a structure-activity relationship study of a series of imidazole-linked pinanamine derivatives was conducted by modifying the imidazole ring of this compound Several compounds of this series inhibited the amantadine-sensitive virus at low micromolar concentrations Among them, (II) (R1,R2,R3=alkyl) was the most potent compound, which was identified as being active on an amantadine-sensitive virus through blocking of the viral M2 ion channel. Furthermore, II markedly inhibited the amantadine-resistant virus (IC50 = 3.4 μM) and its activity increased by almost 24-fold compared to initial compound, with its action mechanism being not M2 channel mediated.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Related Products of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Haneda, Satoshi; Okui, Ayaka; Ueba, Chigusa; Hayashi, Masahiko published the artcile< An efficient synthesis of 2-arylimidazoles by oxidation of 2-arylimidazolines using activated carbon-O2 system and its application to palladium-catalyzed Mizoroki-Heck reaction>, Application In Synthesis of 36947-69-0, the main research area is arylimidazoline activated carbon oxygen oxidation; imidazole aryl preparation; bromotoluene alkene palladium Mizoroki Heck arylimidazoline; alkene bromotoluene palladium Mizoroki Heck arylimidazole; methylphenyl alkene preparation; Mizoroki Heck catalyst palladium arylimidazoline; palladium Mizoroki Heck catalyst arylimidazole.

Oxidative conversion of 2-substituted imidazolines (dihydroimidazoles) to the corresponding imidazoles, e.g., I, was achieved by an activated carbon-O2 system. Also, the 2-arylimidazolines and 2-arylimidazoles have been found to work as simple ligands in the palladium-catalyzed Mizoroki-Heck reaction.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (imidazolinyl). 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Application In Synthesis of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Akiyama, Masayasu; Hara, Yukihiro; Tanabe, Minoru published the artcile< Effects of the substituents on the hydrolysis of 4-nitrophenyl acetate catalyzed by 2-substituted imidazoles>, Computed Properties of 36947-69-0, the main research area is hydrolysis kinetics nitrophenyl acetate imidazole; Broensted catalysis nitrophenyl acetate hydrolysis; mechanism hydrolysis nitrophenyl acetate imidazole; LFER hydrolysis nitrophenyl acetate.

A series of 2-alkyl and -(hydroxyalkyl)-substituted imidazoles catalyzed the hydrolysis of 4-nitrophenyl acetate. Activation parameters and D2O solvent isotope effects were determined for some of these imidazoles and showed that a bulky substituent decreased the rate of nucleophilic catalysis for most of the imidazoles. Anal. in terms of the Broensted catalysis law gave an extrapolated rate for each imidazole and indicated the importance of the steric effect relative to the parent compound Catalysis by 2-(1,1-dimethyl-2-hydroxyethyl)imidazole involved partial general base catalysis.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about Bronsted LFER. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Computed Properties of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kaiser, Carl; Spagnuolo, Ciro J.; Adams, Theodore C. Jr.; Audia, Vicki H.; Dupont, Andrea C.; Hatoum, Holia; Lowe, Valerie C.; Prosser, Judith C.; Sturm, Bonnie L.; Noronha-Blob, Lalita published the artcile< Synthesis and antimuscarinic properties of some N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones>, SDS of cas: 36947-69-0, the main research area is aminomethyldiphenylfuranone antimuscarinic structure activity; furanone aminomethyldiphenyl antimuscarinic structure activity; urinary incontinence treatment imidazolylmethyldiphenylfuranone; benactyzine constrained analog structure activity.

In a study aimed toward developing new, selective antimuscarinic drugs with potential utility in the treatment of urinary incontinence associated with bladder muscle instability, a series of N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones I (R = Me, R1 = alkyl, aralkyl; R = R1 = Et, Pr; NRR1 = pyrrolidino, N-methylpiperazino, N-phenylpiperazino, morpholino, substituted imidazol-1-yl, substituted pyrazol-1-yl, triazol-1-yl, substituted imidazopyridin-1-yl, etc.), conformationally-constrained lactone relatives of benactyzine, was prepared The compounds were examined in several paradigms that measure muscarinic (M1, M2, and M3) receptor antagonist activity. Selected members of the series that displayed potency and/or selectivity in these tests were studied for their effects on urinary bladder contraction, mydriasis, and salivation in guinea pigs. These studies revealed that incorporation of the amino functionality into an imidazole or pyrazole ring resulted in some novel, potent, and selective antimuscarinic agents. Appropriate alkyl substitution of position 2 of the imidazole strikingly affected muscarinic, particularly M3, receptor activity and may reflect a complementary site of interaction. Some of the compounds selectively reduced bladder pressure in a cystometrogram (CMG) model without producing concomitant mydriatic and salivary effects. The sep. and distinct action of several compounds of this series in these in vivo protocols suggests the possibility of subtypes of muscarinic receptors that may correspond to previously characterized mol. cloned subpopulations. Structure-activity relationships of this series of substituted lactones are discussed. These studies led to the identification of (R)-isomer II as a clin. candidate for treating urinary bladder dysfunction.

Journal of Medicinal Chemistry published new progress about Muscarinic antagonists. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, SDS of cas: 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Godefroi, E. F.; Loozen, H. J. J.; Luderer-Platje, J. Th. J. Mrs. published the artcile< Synthesis of 1,2-disubstituted imidazole-5-carboxaldehydes and-4,5-dicarboxaldehydes>, Application In Synthesis of 36947-69-0, the main research area is formylation imidazole; imidazotropones; imidazopyridazine; pyridazine imidazo.

1,2-Disubstituted imidazoles react with refluxing 37% CH2O in Ac2O-NaOAc buffer. Both 5-hydroxymethyl- and 4,5-bis(hydroxymethyl)imidazole derivatives are formed in 25-50% yields. Bis(hydroxymethylation) is favored by prolonged reaction and is dependent upon the nature of the C-2 substituent. Oxidation of the mono- and dihydroxymethylimidazoles by Pb(OAc)4 in pyridine affords the imidazole-mono- and -dicarboxaldehydes. A few reactions of 1-benzyl-2-isopropylimidazole-4,5-dicarboxaldehyde (I) with certain ketones and with hydrazine are described.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 36947-69-0. 36947-69-0 belongs to class imidazoles-derivatives, and the molecular formula is C7H12N2, Application In Synthesis of 36947-69-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem