In 1965,Nature (London, United Kingdom) included an article by Burton, D. E.; Lambie, A. J.; Ludgate, J. C. L.; Newbold, G. T.; Percival, A.; Saggers, D. T.. Recommanded Product: 3671-65-6. The article was titled 《2-Trifluoromethylbenzimidazoles: a new class of herbicidal compounds》. The information in the text is summarized as follows:
The herbicidal activity of 2-trifluoromethylbenzimidazoles was studied on postemergent and preemergent peas (Pisum sativum), mustard (Sinapis alba), linseed (Linum usitatissimum), beet (Beta vulgaris), buckwheat (Fagopyrum esculentum), and barley (Hordeum vulgare); mammalian toxicity was studied in rats. The herbicidal activity of 2-trifluoromethylbenzimidazole was enhanced by 5-halo substitution, the order of activity being iodo and bromo > chloro > fluoro. 5-Cyano-2-trifluoromethylbenzimidazole, 5-nitro-2-trifluoromethylbenzimidazole, and 5-trifluoromethyl-2-trifluoromethylbenzimidazole had the same overall activity as 5-iodo-2-trifluoromethylbenzimidazole. 5 – Methyl -2 – trifluoromethylbenzimidazole, 5-methoxy-2-trifluoromethylbenzimidazole, and 5-amino-2-trifluoromethylbenzimidazole were as active as the parent compound Variation in species specificity with slight modification to structure was observed in the halogen series, where selectivity in favor of peas increased 4-fold from the 5-fluoro to the 5-iodo derivatives, the reverse occurring in the case of barley. Mammalian toxicity tended to follow the herbicidal activity with the exception that the 5-iodo and 5-bromo compounds had a lower mammalian toxicity than 5-chloro-2-trifluoromethylbenzimidazole. Compounds with good herbicidal activity had pKa values of 5-8, with the exception of 5-tert-butyl-2-trifluoromethylbenzimidazole. The preemergent activity of 2-trifluoromethylbenzimidazoles was significant but of less interest. The experimental process involved the reaction of 6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole(cas: 3671-65-6Recommanded Product: 3671-65-6)
6-Methoxy-2-(trifluoromethyl)-1H-benzo[d]imidazole(cas: 3671-65-6) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Recommanded Product: 3671-65-6 In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem