Category: 35445-32-0

Reference of 35445-32-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35445-32-0 as follows.

ethyl [2-BROM-1,] [4-DIMETHYL-1] H-imidazole-5-carboxylate To a solution of intermediate 93 (1.69 [G,] 0.01 mol) in CH3CN (60 mL) was added [NBS (2.15 G, 1.2 EQ. ) AND THE REACTION WAS STIRRED AT RT FOR 1 NIGHT. AFTER EVAPORATION] of the solvant, the residue was dissolved in DCM and washed with water. The organic layer was dried over [NA2SO4] and evaporated off. After purification by flash chromatography using DCM/MeOH 90/10 as eluent, the title compound was obtained as yellow crystals (0.645 g, 2.6 [MMOL)] in 26percent yield ;’H NMR [(CDC13,] 300 MHz) [S] 4.55 (q, 2H), 4.09 (s, 3H), 2.69 (s, 3H), 1.61 (t, 3H)

According to the analysis of related databases, 35445-32-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/6922; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35445-32-0, name is Ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H12N2O2

[2758] To a stirred solution of compound 965 (680 mg) in 10 ml THF at -78¡ã C. was added dropwise 1.0M LAH in THF (5.0 ml). Reaction was stirred and allowed to warm to room temperature overnight. Cooled reaction mixture to 0¡ã C. then added 5 ml of H2O dropwise. Allowed reaction to warm to room temperature while stirring for 1 hr. Filtered through celite and rinsed with 20 ml THF/40 ml H2O. A clear filtrate obtained. Filtrate afforded compound 966.

According to the analysis of related databases, 35445-32-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schering Corporation; US2004/122018; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 35445-32-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35445-32-0 name is Ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Add NaOH (0.451 g, 10.7 mmol) to a solution of ethyl 3,5-dimethylimidazole-4- carboxylate (1.00 g, 5.35 mmol) in EtOH (5 mL) and water (5 mL). Stir the reaction mixture at 60 ¡ãC for 1 hr. Concentrate the solution to give the title compound (0.960 g, 99.6percent) as a yellow solid. LC/MS (mlz): 141 (M-21).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; HU, Zhilong; LIU, Lianzhu; MA, Tianwei; ZENG, Mi; ZHANG, Haizhen; (37 pag.)WO2018/14800; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem