353258-31-8 Archives - Imidazoles-derivatives

Lahm, George P. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 353258-31-8

Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate

The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes was written by Lahm, George P.;Desaeger, Johan;Smith, Ben K.;Pahutski, Thomas F.;Rivera, Michel A.;Meloro, Tony;Kucharczyk, Roman;Lett, Renee M.;Daly, Anne;Smith, Brenton T.;Cordova, Daniel;Thoden, Tim;Wiles, John A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate The following contents are mentioned in the article:

Fluazaindolizine is a new highly effective and selective product for the control of plant parasitic nematodes. Specificity for nematodes coupled with absence of activity against the target sites of com. nematicides suggests that fluazaindolizine has a novel mode of action. The discovery, structure-activity development and biol. properties for this new class of nematicides are presented. This study involved multiple reactions and reactants, such as Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lahm, George P. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 353258-31-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wei, Chengqian et al. published their research in Pesticide Biochemistry and Physiology in 2021 | CAS: 353258-31-8

Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C11H8ClF3N2O2

Novel amide derivatives containing an imidazo[1,2-a]pyridine moiety: Design, synthesis as potential nematicidal and antibacterial agents was written by Wei, Chengqian;Huang, Junjie;Luo, Yuqin;Wang, Shaobo;Wu, Sikai;Xing, Zhifu;Chen, Jixiang. And the article was included in Pesticide Biochemistry and Physiology in 2021.COA of Formula: C11H8ClF3N2O2 The following contents are mentioned in the article:

To discover new nematicides I (n = 1, 2, 3; R = Et, iso-Pr, 4-nitrobenzyl, etc.) a series of novel amide derivatives containing an imidazo[1,2-a]pyridine moeity I were designed and synthesized. Among the title compounds, compounds I (n = 1; R = Pr and n = 3; R = n-decyl (III)) exhibited good nematicidal activities against Aphelenchoides besseyi (rice white-tip nematode), with LC₅₀ values against of 27.3 and 35.9 mg/L, resp., which were superior to that of fosthiazate (45.4 mg/L). Meanwhile, the LC₅₀ value of compound III against Caenorhabditis elegans was 5.7 mg/L, which was superior to that of fosthiazate (77.2 mg/L). Compound III not only binds well to acetylcholinesterase (AChE) of nematodes, but also has a good inhibitory activity against AChE. Thus, AChE may be a potential target of compound III against nematodes. Unexpectedly, compound I (n = 1; R = chloromethyl (IV)) exhibited excellent antibacterial activities with EC₅₀ values of 1.2 and 3.1 mg/L against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc), resp., which were superior to those of bismerthiazol (68.6 and 77.1 mg/L) and thiodiazole copper (80.8 and 96.6 mg/L). The curative and protective activities of compound IV against bacterial leaf blight were 37.0% and 36.8% at 50 mg/L, resp., which were higher than those of thiodiazole copper (16.1% and 15.5%). In addition, compound IV may inhibit the growth of Xoo by affecting the production of cell membranes and extracellular polysaccharides. Amide derivatives containing an imidazo[1,2-a]pyridine moeity Ican be used as good lead-structures to discover new nematicidal and antibacterial agents in the future. This study involved multiple reactions and reactants, such as Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8COA of Formula: C11H8ClF3N2O2).

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem