A common heterocyclic compound, 33543-78-1, name is Ethyl 1H-imidazole-2-carboxylate, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 33543-78-1.
First step The compound (85) (2.50 g) was dissolved in pyridine (25 ml), trityl chloride (5.47 g) and dimethylaminopyridine (2.40 g) were added, the mixture was stirred at 100¡ãC for 22 hours. Water was added, the mixture was extracted with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography to afford the compound (86) (2.81 g). 1H-NMR (CDCl3), delta: 0.94 (3H, t, J = 7.1 Hz), 3.82 (2H, q, J = 7.1 Hz), 6.97 (1H, d, J = 1.0 Hz), 7.12 (7H, m), 7.28-7.30 (9H, m).
The synthetic route of Ethyl 1H-imidazole-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shionogi & Co., Ltd.; EP2305672; (2011); A1;,
Imidazole – Wikipedia,
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