Application of 33469-36-2,Some common heterocyclic compound, 33469-36-2, name is 2-Phenyl-4-(trifluoromethyl)-1H-imidazole, molecular formula is C10H7F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Avessel containing 2-(2,6-dimethoxyphenyl)-4-(trifluoromethyl)-1H-imidazole (A) (3.734 g, 13.7 mmol) was chargedwith 18 mL of 3.75 N sodium hydroxide.The vessel was equipped with a condenser and heated in a 100 C oil bathfor 22 h. The mixture was cooled,diluted with 20 mL of water and washed once with 20 mL of ethyl acetate. The pH of the aqueous part was adjusted toca. 3 with 3 M HCl. The turbid solutionwas placed in a refrigerator for 5 h before collecting a solidprecipitate. The filtrate wasrefrigerated overnight to yield a smaller second crop for a combined recoveryof 3.202 g (94%) of 2-(2,6-dimethoxyphenyl)-1H-imidazole-4-carboxylic acid (B) as a pale pink solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Phenyl-4-(trifluoromethyl)-1H-imidazole, its application will become more common.
Reference:
Article; Hershberger, Paul M.; Hedrick, Michael P.; Peddibhotla, Satyamaheshwar; Mangravita-Novo, Arianna; Gosalia, Palak; Li, Yujie; Gray, Wilson; Vicchiarelli, Michael; Smith, Layton H.; Chung, Thomas D.Y.; Thomas, James B.; Caron, Marc G.; Pinkerton, Anthony B.; Barak, Lawrence S.; Roth, Gregory P.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 262 – 267;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem