Category: 3287-79-4

Related Products of 3287-79-4,Some common heterocyclic compound, 3287-79-4, name is 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C9H10N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Ethylthio-5,6-dimethylbenzimidazole (I). 0,65 g (6 mmol) Ethylbromide was added to a solution 0,89 g (0,005 mol) 2-mercapto-5,6-dimethylbenzimidazole and 0,24 g (0,006 mol) sodium hydroxide in 1 ml of water and 10 ml of ethanol. The reaction mixture was refluxed for 1.5 hr before disappearing starting thione (control by using TLS), cooled and added water. The precipitated product was filtered off, washed with water and dried under atmospheric conditions. The yield was 0,91 g (88%) of compound I, m.p. 123-124 C. (from water-ethanol).1H NMR (CDCl3), delta: 1.37 (3H, t, CH2CH3); 2,32 (6H, s, 2CH3); 3,27 (2H, q, CH2CH3); 7,31 (2H, s, ArH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione, its application will become more common.

Reference:
Patent; Nauchno-Issledovatelsky Institut Farmakologii Rossiiskoi Akademii Meditsinskikh Nauk; US6376666; (2002); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3287-79-4 as follows. Computed Properties of C9H10N2S

Example 20 Preparation of Compound No. 952 To 5,6-dimethylbenzimidazole-2-thiol (713 mg, 4 mmol) in dimethylformamide (10 ml), triethylamine (836 mul, 6 mmol) and 2-bromomethylbenzonitrile (1176 mg, 6 mmol) were added. After stirring at 80 C. overnight, water was added to the mixture, followed by extraction with ethyl acetate. After the ethyl acetate phase was dried with anhydrous sodium sulfate, it was concentrated and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:2) to obtain 2-((5,6-dimethylbenzimidazole-2-ylthio)methyl)benzenecarbonitrile (1159 mg, yield 99%).

According to the analysis of related databases, 3287-79-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TEIJIN LIMITED; US2005/267148; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 3287-79-4, name is 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione

Example 13. 2-[2-(Pyrrolidino)ethylthio]-5,6-dimethylbenzimidazole (XIII) and its dihydrochloride were synthesised as described above. The compound XIII was obtained from 2,67 g (0,015 mol) 2-mercapto-5,6-dimethylbenzimidazole and 2,9 g (0,017 mol) 2-(pyrrolidino)ethylchloridehydrochloride in the presence 1,35 g (0,034 mol) sodium hydroxide in 90% yield (4,0 g, counting on monohydrate), m.p. 115-116 C. (with decomp., from ethanol with water). 1H NMR (CDCl3), delta: 1,97 (4H, m, beta-H of pyrrolidine); 2,34 (6H, s, 2CH3); 2,72 (4H, m, -H of pyrrolidine); 3,02 (2H, m, CH2S); 3,19 (2H, m, CH2N); 7,18 (2H, broad s, ArH). Calcd for C15H21N3S*H2O: C 61,4; H 7,8; N 14,3; S 10,9; Found: C 61,4; H 7,8; N 14,5; S 10,9.

The synthetic route of 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nauchno-Issledovatelsky Institut Farmakologii Rossiiskoi Akademii Meditsinskikh Nauk; US6376666; (2002); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 3287-79-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3287-79-4, name is 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 5,6-dimethyl-2-mercaptobenzimidazole (9.45 g, 0.053 mole), 1,8-diazabicyclo [5.4.0] undec-7-ene (9.7 g, 0.064 mole) and 1-iodo-2,2,2-trifluroethane (13.4 g, 0 064 mole) in 210 ml dimethylformamide is heated (50 C. for 41/2 hours), poured onto ice and water (1500 ml), and the precipated solid collected by filtration and dried. The product is recrystallized from toluene-ligroine giving 5,6-dimethyl-2-(2,2,2-trifluoroethyl-mercapto)-1H-benzimidazole (3.4 g, 0.013 mole), m.p. 150-163 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6-Dimethyl-1H-benzo[d]imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US4608381; (1986); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem