Category: 3273-68-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3273-68-5, name is 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, A new synthetic method of this compound is introduced below., 3273-68-5

Part A. Preparation of chloro 2,3-dihydro-2-oxo-lH-benzimidazol-l- butanoate.4-(2-oxo-2,3- chloro 2,3-dihydro-2-oxo- dihydrobenzimidazol-l-yl)butyric acid lH-benzimidazol-1-butanoate4-(2-Oxo-2,3-dihydrobenzimidazol-l-yl)butyric acid (50 g; 0.227 mol), N ,N- dimethylformamide (1.84 g; 0.025 mol; 0.11 eq), and dichloromethane (480 g; 5,652 mol; 24.89 eq) were charged to a stirred-tank reactor. Oxalyl chloride (31.12 g; 0.245 mol; 1.08 eq) was then dosed at 10-200C over a 1-hour period while stirring. The resulting mixture was then stirred at 10-200C for an additional hour. All the above steps were conducted under a N2 atmosphere.; Part A. Preparation of chloro 2,3-dihydro-2-oxo-lH-benzimidazol-l- butanoate.4-(2-oxo-2,3- chloro 2,3-dihydro-2-oxo- dihydrobenzimidazol-l-yl)butyric acid lH-benzimidazol-1-butanoateDichloromethane (3772 L) and then 4-(2-oxo-2,3-dihydrobenzimidazol-l-yl)butyric acid (525 kg; 2.4 kmol) were charged to a stirred-tank reactor, followed by N5N- dimethylformamide (21 L). The resulting mixture was cooled to 1O0C. Afterward, oxalyl chloride (326.8 kg)) was dosed at 10-150C over 2-3 hours while stirring. The resulting mixture was then stirred at 15-2O0C for an additional 1-3 hours. All the above steps were conducted under a N2 atmosphere. Conversion was checked by in-process control (“IPC”).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; WO2008/119754; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

3273-68-5, name is 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid

To a solution of the compound of Preparation 5 (45.0 g, 0.2 mol) in dichloromethane (150 ml) was added thionyl chloride (30 ml, 0.4 mol) and the reaction mixture was stirred at room temperature for 2 h.

The synthetic route of 3273-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; US2008/103130; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3273-68-5, name is 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid

Part A. Preparation of chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate. Dichloromethane (3772 L) and then 4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)butyric acid (525 kg; 2.4 kmol) were charged to a stirred-tank reactor, followed by N,N-dimethylformamide (21 L). The resulting mixture was cooled to 10 C. Afterward, oxalyl chloride (326.8 kg)) was dosed at 10-15 C. over 2-3 hours while stirring. The resulting mixture was then stirred at 15-20 C. for an additional 1-3 hours. All the above steps were conducted under a N2 atmosphere. Conversion was checked by in-process control (“IPC?).

According to the analysis of related databases, 3273-68-5, the application of this compound in the production field has become more and more popular.

3273-68-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3273-68-5 as follows.

Preparation 4; 5,6-Dihydroimidazor4.5.1-/7c1f1lbenzazepine-2,7(1H,4H)-dione; To a solution of the compound of Preparation 5 (45.0 g, 0.2 mol) in dichloromethane (150 ml) was added thionyl chloride (30 ml, 0.4 mol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was concentrated in vacuo and to the residue was added dichloromethane (1000 ml) and aluminium chloride (84.0 g, 0.6 mol), added portionwise. After stirring at room temperature overnight, the reaction mixture was heated under reflux for 2 h and then concentrated in vacuo. To the residue was added ice water (2000 ml) and concentrated hydrochloric acid (50 ml), followed by additional ice water(2000 ml). The resulting precipitate was collected by filtration, washed with water (4 x 250 ml) and dissolved in sodium hydroxide solution (1 N, 600 ml). The solution was washed with dichloromethane (2 x 150 ml) and cyclohexane (150 ml) and adjusted to pH 10 by addition of dry ice. The solid material was collected by filtration, washed with water (3 x 50 ml) and dried overnight at 40C to give the title compound (30.0 g).1H-NMR (cfe-DMSO): 2.03 – 2.11 (2H), 2.90 – 3.00 (2H), 3.85 – 3.95 (2H), 7.02 – 7.10 (1 H), 7.17 – 7.24 (1 H), 7.50 – 7.58 (1 H)

According to the analysis of related databases, 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; WO2008/44127; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3273-68-5, name is 4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)butanoic acid, A new synthetic method of this compound is introduced below., 3273-68-5

Part A. Preparation of chloro 2,3-dihydro-2-oxo-lH-benzimidazol-l- butanoate.4-(2-oxo-2,3- chloro 2,3-dihydro-2-oxo- dihydrobenzimidazol-l-yl)butyric acid lH-benzimidazol-1-butanoate4-(2-Oxo-2,3-dihydrobenzimidazol-l-yl)butyric acid (50 g; 0.227 mol), N ,N- dimethylformamide (1.84 g; 0.025 mol; 0.11 eq), and dichloromethane (480 g; 5,652 mol; 24.89 eq) were charged to a stirred-tank reactor. Oxalyl chloride (31.12 g; 0.245 mol; 1.08 eq) was then dosed at 10-200C over a 1-hour period while stirring. The resulting mixture was then stirred at 10-200C for an additional hour. All the above steps were conducted under a N2 atmosphere.; Part A. Preparation of chloro 2,3-dihydro-2-oxo-lH-benzimidazol-l- butanoate.4-(2-oxo-2,3- chloro 2,3-dihydro-2-oxo- dihydrobenzimidazol-l-yl)butyric acid lH-benzimidazol-1-butanoateDichloromethane (3772 L) and then 4-(2-oxo-2,3-dihydrobenzimidazol-l-yl)butyric acid (525 kg; 2.4 kmol) were charged to a stirred-tank reactor, followed by N5N- dimethylformamide (21 L). The resulting mixture was cooled to 1O0C. Afterward, oxalyl chloride (326.8 kg)) was dosed at 10-150C over 2-3 hours while stirring. The resulting mixture was then stirred at 15-2O0C for an additional 1-3 hours. All the above steps were conducted under a N2 atmosphere. Conversion was checked by in-process control (“IPC”).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; WO2008/119754; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem