Category: 32692-19-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32692-19-6, name is 5-Nitroindoline, A new synthetic method of this compound is introduced below., name: 5-Nitroindoline

Example V; 5-nitro-1 -pyrimidin-2-yl-2,3-dihydro-1 H-indole300 mg 5-nitro-2,3-dihydro-1 H-indole are dissolved in 4 ml N-methyl- pyrrolidine. 80 mg NaH (60 % suspension in mineral oil) are added and the mixture is stirred for 15 minutes at ambient temperature. Then 380 mg of 2- bromopyrimidine are added and the mixture is then heated to 600C for 3 hours. It is then diluted with diethyl ether and washed with dilute citric acid solution and saturated sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo. Yield: 410 mg (95 % of theory) Rf value: 0.61 (silica gel: ethyl acetate/petroleum ether 1 :1 )

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16118; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32692-19-6, name is 5-Nitroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H8N2O2

To a solution of 5-nitroindoline (11.72 g) and triethylamine (8.67 g) in N, N-dimethylformamide (150 ml) was added dropwise chloroacetyl chloride (8.06 g) at 5C and the mixture was stirred at ambient temperature for 20 hours. The mixture was poured into a mixture of ethyl acetate and water and the separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with ethyl acetate and collected by filtration to give 1- (CHLOROACETYL)-5-NITROINDOLINE (14.66 g) as a yellow crystal. 1H-NMR (DMSO-d6): 8 3. 28 (2H, t, J=8.6 Hz), 4.25 (2H, t, J=8.6 HZ), 4.64 (2H, s), 8.1-8. 2 (3H, m) ESI-MS (m/z): 263 (M+Na) +

The synthetic route of 32692-19-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; DAISO CO., LTD.; WO2004/39795; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem