326-55-6, name is 6-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 6-(Trifluoromethyl)-1H-benzo[d]imidazole
Add 0.3mmol 5-trifluoromethylbenzimidazole, 0.009mmol photosensitizer, 0.6m mol sodium hydroxide to a 15ml schlenck tube,After the nitrogen protection was completed, 0.6 mmol of ethyl bromodifluoroacetate and 3 mL of DMF were added with a syringe.Then, it reacted at room temperature for 12 hours under 15 W blue light irradiation.After the reaction, add two medicine spoon column chromatography silica gel (100-200 mesh) to the reaction solution, and remove the solvent by distillation under reduced pressure.The product was purified by column chromatography (petroleum ether / ethyl acetate = 50: 1 as eluent). The material was a yellow liquid with a yield of 73%.
The synthetic route of 326-55-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Liu Yunkui; Hu Xiaojun; Zhou Bingwei; (10 pag.)CN110483406; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem