Category: 31722-49-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31722-49-3, name is 1H-Imidazole-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 31722-49-3

Compound 234.2. 5-Iodo-lH-imidazole-2-carbonitrile. Into a 100-mL round- bottom flask, was placed a solution lH-imidazole-2-carbonitrile (compound 234.1, 3.39 g, 36.42 mmol) in sodium hydroxide (54.7 mL, 2 M). Iodine (9.26 g, 36.46 mmol) was added to the reaction. The reaction mixture was stirred for 5h at room temperature. The pH of the solution was adjusted to 5 with HCl (2 M). The aqueous phase was extracted with 3 x 80 mL of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography with ethyl acetate/petroleum ether (1/1.5) as eluent to furnish 1.02 g (13%) of the title compound as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; 3-V BIOSCIENCES, INC.; HEUER, Timothy Sean; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2015/95767; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 31722-49-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31722-49-3, name is 1H-Imidazole-2-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

At -78C, 1.6 ml of methylmagnesium bromide (3 M, diethyl ether solution) was added to a tetrahydrofuran (3 ml) solution of 151 mg of 1H-imidazole-2-carbonitrile obtained in Example 82 (step 1), and stirred at that temperature for 1 hour. Aqueous saturated ammonium chloride solution was added to it, extracted with ethyl acetate and chloroform, and the organic layer was dried, and the solvent was evaporated away under reduced pressure to obtain 187 mg of the entitled compound as a yellow solid.

The synthetic route of 1H-Imidazole-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1810969; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31722-49-3, name is 1H-Imidazole-2-carbonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C4H3N3

l,8-Diazabicyclo[5.4.0]undec-7-ene (7.28 mL, 48.75 mmol) was added to a stirred solution of (R)-tert-butyl-4-(5-bromo-2-fluorophenyl)-4-methyl-l,2,3-oxathiazolidine- 3-carboxylate 2,2-dioxide (10 g, 24.4 mmol) and lH-imidazole-2-carbonitrile (2.61 g, 28.03 mmol) in acetonitrile (80 mL). The mixture was stirred at 90 C for 18 hours and then diluted with HCl (1 M) and extracted with DCM. The organic layer was separated, dried (Na2S04), filtered and the solvent was evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in DCM 0/100 to 10/90). The desired fractions were collected and concentrated in vacuo to yield (R)-tert-buty [ 1 -(5-bromo-2-fluorophenyl)-2-(2-cyano- lH-imidazol- 1 -yl)- 1 -methylethyljcarbamate (10 g, 97 % yield) as a sticky solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; TRABANCO-SUAREZ, Andres, Avelino; DELGADO-JIMENEZ, Francisca; VEGA RAMIRO, Juan, Antonio; TRESADERN, Gary, John; GIJSEN, Henricus, Jacobus, Maria; OEHLRICH, Daniel; WO2012/85038; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

These common heterocyclic compound, 31722-49-3, name is 1H-Imidazole-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Imidazole-2-carbonitrile

6.7. Synthesis of aR,2S,3R)-l-aH,l’H-2,2′-biimidazol-5-yl)butane-l,2,3,4- tetraolThe captioned compound was prepared by General Method B with the following alterations. To a solution of lH-imidazole-2-carbonitrile (0.39 g, 4.17 mmol) in methanol (4.8 ml) was added a solution of sodium methoxide in methanol (25 wt%, 0.54 g, 0.57 ml, 2.50 mmol), stirred for 16 h and compound 8 (0.964 g, 4.17 mmol) was added in 10 ml of MeOH. A precipitate formed and was filtered and washed with acetone (15 ml). The filtrate was concentrated to dryness, and was purified by preparative HPLC (10 mM aq ammonium acetate/acetonitrile) to give the title compound (0.0141 g, 0.0554 mmol) as an off-white solid. MS m/z Ci0Hi4N4O4 [M + H] + = 255; 1H NMR (400 MHz, CD3OD) delta 3.56-3.57 (m, 2H), 3.67-3.74 (m, 2H), 4.90 (s, IH), 7.04 (s, IH).

The synthetic route of 1H-Imidazole-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/109314; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 31722-49-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31722-49-3 as follows.

A mixture of (2R ,5R)-5-chloromethyl-4-{2-[6-(4-fluoro-benzyl)-3, 3-dimethyl-2, 3-dihydro-pyrrolo[3,2-b]pyridin- 1 -yl]-2-oxo-ethyl}-2-methyl-piperazine- 1 -carboxylic acid tert-butyl ester(0.10 g, 0.18 mmol), 2-cyanoimidazole (0.025 g, 0.27 mmol), potassium carbonate (0.10 g, 0.72 mmol) and potassium iodide (0.09 g, 0.54 mmol) in acetonitrile (5 mL) was heated at 90 O for 18 h, cooled, then partitioned between water (30 mL) and DCM (3 x 20 mL). Thecombined organic extracts were dried and evaporated to give an oil. Chromatography (Si02,0 – 100% EtOAC in petrol gradient) gave the title compound (0.102 g) as an oil. MS: [M+H]= 602.

According to the analysis of related databases, 31722-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; CHESSARI, Gianni; JOHNSON, Christopher Norbert; PAGE, Lee William; MILLEMAGGI, Alessia; HOWARD, Steven; SAXTY, Gordon; HEIGHTMAN, Thomas Daniel; WO2014/60768; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31722-49-3, name is 1H-Imidazole-2-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1H-Imidazole-2-carbonitrile

At -78C, 1.6 ml of methylmagnesium bromide (3 M, diethyl ether solution) was added to a tetrahydrofuran (3 ml) solution of 151 mg of 1H-imidazole-2-carbonitrile obtained in Example 82 (step 1), and stirred at that temperature for 1 hour. Aqueous saturated ammonium chloride solution was added to it, extracted with ethyl acetate and chloroform, and the organic layer was dried, and the solvent was evaporated away under reduced pressure to obtain 187 mg of the entitled compound as a yellow solid.

The synthetic route of 31722-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1810969; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 31722-49-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31722-49-3, name is 1H-Imidazole-2-carbonitrile belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

SYNTHESIS EXAMPLE 1 Synthesis of 2-cyano-1-dimethylsulfamoylimidazole (Compound No. 1) Thirty grams of 2-cyanoimidazole, 53.4 g of anhydrous potassium carbonate and 600 ml of acetonitrile were mixed at room temperature. After reacting for 2 hours at the refluxing temperature, the reaction mixture was cooled, and 55.6 g of dimethylsulfamoyl chloride was added thereto. The mixture was reacted again at the refluxing temperature for 2 hours. After completion of the reaction, the reaction mixture was poured into water. Extraction with methylene chloride was carried out. After washing with water, the extract was dried over anhydrous sodium sulfate. The solvent was removed by distillation. The obtained residue was purified by silica gel column chromatography (developing solvent: methylene chloride) to give 28.0 g of 2-cyano-1-dimethylsulfamoylimidazole (Compound No. 1) having a melting point of from 74 to 76 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ishihara Sangyo Kaisha, Ltd.; US4995898; (1991); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem