Introduction of a new synthetic route about 312-73-2

The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.

Related Products of 312-73-2, A common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound II (60.00g, 0.322mol, 1.0eq.) And cesium carbonate (159.98g, 0.483mol, 1.5eq.) Were added to 600mL DMF, and ethyl iodide (75.33g, 0.483mol, 1.5) was added dropwise at 0 C. eq.), the reaction was completed at 25 C for 1h after the addition, TLC showed that the raw materials had reacted, the system was poured into 1L of ice water, washed with water (100mL * 2), filtered to obtain a white solid, washed with water (100mL * 2), white The solid was dissolved with ethyl acetate, dried over anhydrous magnesium sulfate, and concentrated to obtain compound III-2 as a white solid 61.01g, yield: 88.5%.

The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Yaoshi Technology Co., Ltd.; Wang Zhengjiang; Xia Aihua; (15 pag.)CN110903245; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New learning discoveries about 312-73-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 312-73-2, Formula: C8H5F3N2

General procedure: mixtureof benzimidazole derivative (0.01 mol, insoluble in H2O) and correspondingacid (0.01 mol, insoluble in H2O) in absolute methanol (25 ml)was stirred at 65 C for 1-3 h. The solvent was distilled off, and theresidue was multiply washed with diethyl ether and dried (24 h) overP2O5 at ~0.01 Torr to afford viscous liquids or powders (soluble in water).Compounds 14, 15 were prepared by the reaction of ion exchange undersimilar conditions for 7-8 h.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Adamovich, Sergei N.; Mirskova, Anna N.; Mirskov, Rudolf G.; Lopyrev, Valentin A.; Mendeleev Communications; vol. 22; 6; (2012); p. 330 – 331;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 312-73-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethyl)-1H-benzo[d]imidazole, its application will become more common.

Reference of 312-73-2,Some common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

G. Synthesis of Compounds 46 and 47A stirred mixture of 2-Trifluoromethyl-I H-benzoimidazole (4.92g, 26.4 mmol), 4-fluorobenaldehyde (3.1 mL, 29.1 mmol), and K2CO3 (4.37g, 31.7 mmol) in DMF (50 mL) was heated to 150 0C for 16 h. After being cooled to room temperature, the reaction mixture was partitioned between H2O and EtOAC. After usual workup, the crude product was purified by silica gel chromatography (20% Hexane/EtOAc to 30% Hexane/EtOAc) to afford a yellow oil which was subjected to a second silica gel chromatography (DMC) to provide the aldehyde intermediate 4-(2-Trifluoromethyl-benzoimidazol-1-yl)- benzaldehyde as a white solid (4.0 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethyl)-1H-benzo[d]imidazole, its application will become more common.

Reference:
Patent; SYNTA PHARMACEUTICAL CORP.; WO2006/34402; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Sources of common compounds: 312-73-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

Adding some certain compound to certain chemical reactions, such as: 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 312-73-2. 312-73-2

General procedure: A solution of this chloromethyl ester (1.8 mmol) in N,N-dimethylformamide (4 ml) was treated with the 2-substituted benzimidazoles (1.8 mmol) and cesium carbonate (2.8 mmol). The mixture was stirred for 3 h at r.t. and partitioned with water and ethyl acetate (20 ml). The aqueous layer was further extracted with ethyl acetate (20 ml) and the combined organic layers washed with brine (20 ml), dried (sodium sulfate), filtered and concentrated. Flash chromatography with ethyl acetate provided the desired product as colored oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

Reference:
Article; Sengupta, Prabal; Puri, Chetan S.; Chokshi, Hemant A.; Sheth, Chetana K.; Midha, Ajay S.; Chitturi, Trinadha Rao; Thennati, Rajamannar; Murumkar, Prashant R.; Yadav, Mange Ram; European Journal of Medicinal Chemistry; vol. 46; 11; (2011); p. 5549 – 5555;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Introduction of a new synthetic route about 312-73-2

The synthetic route of 2-(Trifluoromethyl)-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 312-73-2.

To a 200 mL eggplant-shaped flask equipped with a magnetic stirrer, 18.7 g (100 mmol) of 2-trifluoromethylbenzimidazole, 16.6 g (120 mmol) of potassium carbonate, 17.0 g (120 mmol) of methyl iodide and 100 mL of acetone were added. The mixture was heated to reflux for 3 hours. After the reaction mixture was cooled, water was added thereto, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 19.7 g of gray crystals. Yield: 98%. 1H-NMR (400 MHz, CDCl3, relative to TMS) delta (ppm): 3.96 (s, 3H), 7.37-7.46 (m, 3H), 7.88 (d, J=6.0 Hz, 1H).

The synthetic route of 2-(Trifluoromethyl)-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IHARA CHEMICAL INDUSTRY CO., LTD.; KUMIAI CHEMICAL INDUSTRY CO., LTD.; KAWAZOE, Kentaro; YOSHIOKA, Kotaro; (107 pag.)US2017/197920; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new synthetic route of 312-73-2

Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 312-73-2

The 2 – trifluoromethyl – 1H – benzimidazole 2 (1.35g, 10mmol) added to the is provided with a 15 ml round bottom flask in acetone, stirring to dissolve into the ene (alkyne) propyl bromide (0.87 ml, 10mmol) and K2CO3(2.07g, 15mmol), heating to reflux, TCL detection, after the reaction is complete, cooling, filtering to remove the solid, dichloromethane is used for washing the solid, acetone solution concentration after mixing with the dichloromethane solution, H for2O washing (15 ml ¡Á 3), organic phase with anhydrous MgSO4Drying, filtering the concentrated to obtain the crude product. To obtain 1 – allyl -2 – trifluoromethyl – 1H – benzimidazole (3) 2.10g, yield 94.34%.aceo

Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

Reference:
Patent; Zhejiang University of Technology; Zhu, Bingchun; Wang, Yuguang; Dong, Huichan; (15 pag.)CN104496976; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extended knowledge of 312-73-2

Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 312-73-2

2-Trifluoromethyl-1H-benzimidazole 2 (1.35 g, 10 mmol)Was added to a round bottom flask equipped with 15 mL of acetone,After stirring, an alkene (alkyne) propyl bromide (0.87 mL, 10 mmol)And K2CO3 (2.07 g, 15 mmol),Heating reflux,TCL detection,After the reaction is complete,Cooling cooling,The solid was removed by filtration,The solid was washed with dichloromethane,The acetone solution was concentrated and mixed with the dichloromethane solution,Washed with H2O (15 mL x 3),The organic phase was dried over anhydrous MgSO4,Filtered and concentrated to get crude,To obtain 2.06 g of 1-propargyl-2-trifluoromethyl-1H-benzimidazole (3)Yield 91.96%.

Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.

Reference:
Patent; Zhejiang University of Technology; Wang Yuguang; He Rongjun; Dong Huichan; Zhu Bingchun; (14 pag.)CN104496975; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem