Category: 312-73-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312-73-2 as follows. COA of Formula: C8H5F3N2

General procedure: In a typical experimental procedure, a dry, two-necked, 50 mL round bottomed flask was charged with 5 mL of dry MeCN, 1.0 mmol of benzimidazole derivatives and 1.0 mmol of NaH. The solution was stirred at room temperature for 30 min, then a solution of 2,2,2-trifluoro acetimidoyl chloride derivatives (1.0 mmol in 2 mL of dry MeCN) was added dropwise via a syringe. The mixture was stirred at room temperature appropriate time and then filtered. After removing the solvent under reduced pressure, the crude product was purified by preparative thin-layer chromatography on silica gel [eluent: n-hexane/EtOAC, 3:1] to give the products. The products obtained from 2-mercapto benzimidazole and 2-mercapto-1-methyl imidazole were purified by washing with n-hexane.

According to the analysis of related databases, 312-73-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Darehkordi, Ali; Rahmani, Fariba; Journal of Fluorine Chemistry; vol. 190; (2016); p. 41 – 47;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 312-73-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Compound II (60.00g, 0.322mol, 1.0eq.) And potassium carbonate (89.01g, 0.644mol, 2.0eq.) Were added to 600mL DMF, and iodomethane (91.4g, 0.644mol, 2.0eq) was added dropwise at 0 C. .), After the addition was completed, the reaction was performed at 25 C for 1h. TLC showed that the raw materials had reacted. The system was poured into 1L of ice water, washed with water (100mL * 2), filtered to obtain a white solid, washed with water (100mL * 2), white solid Dissolved in ethyl acetate, dried over anhydrous magnesium sulfate, and concentrated to give compound III-1 as a white solid 62.00g, yield: 97.1%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Trifluoromethyl)-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Yaoshi Technology Co., Ltd.; Wang Zhengjiang; Xia Aihua; (15 pag.)CN110903245; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 312-73-2, A common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a methanolic solution (5 mL) of complex 1 (0.5 g, 1.259 mmol) was added dropwise methanolic solution (5 mL) of phen (0.250 g, 1.26 mmol) and the reaction mixture was refluxed at 60 C for 5 h. The reaction mixture yielded a solid product (green coloured) which was isolated, washed with diethyl ether and methanol in portion and dried in vacuum.

The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tabassum, Sartaj; Amir, Samira; Arjmand, Farukh; Pettinari, Claudio; Marchetti, Fabio; Masciocchi, Norberto; Lupidi, Giulio; Pettinari, Riccardo; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 216 – 232;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., SDS of cas: 312-73-2

General procedure: A flame-dried round-bottomed flask was charged with 3-bromoisocoumarine (0.13 mmol) azole (1.2 eq), Pd2(dba)3 (5mol %), Xantphos (10 mol %) and K2CO3 (2.0 eq) in dry toluene (1.0 mL). The mixture was heated under nitrogen atmosphere at 80 C for 12h. After completion of the reaction as indicated by TLC, the mixture was cooled to room temperature and solvent removed under reduced pressure. The crude residue was purified by flash column chromatography on silica gel to afford the corresponding product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Simic, Milena; Paunovic, Nikola; Boric, Ivan; Randjelovic, Jelena; Vojnovic, Sandra; Nikodinovic-Runic, Jasmina; Pekmezovic, Marina; Savic, Vladimir; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 235 – 239;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 312-73-2

The -1H- benzimidazol-2-trifluoromethyl-2 (1.35g, 10mmol) was added to a round bottom flask containing 15mL of acetone were added ene (propargyl) propyl bromide dissolved with stirring (0.87mL, 10mmol) and K2CO3(2.07g, 15mmol), was heated under reflux, TCL is detected, after completion of the reaction, cooling was cooled, solid was removed by filtration, the solid was washed with methylene chloride, the solution was concentrated acetone solution was mixed with dichloromethane, washed with H2O wash (15mL × 3), the organic phase was dried over anhydrous MgSO4Dried, filtered and concentrated to give crude product.To give 1-propargyl-2-trifluoromethyl–1H- benzoimidazol (3) 2.06g, yield 91.96%.

The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University of Technology; Wang, Yuguang; Zhu, Bingchun; Dong, Huichan; (11 pag.)CN104530008; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-(Trifluoromethyl)-1H-benzo[d]imidazole

The 4-(4-aminopiperidin- 1 -yl)-6-morpholino-2-(2-trifluoromethylbenzimidazol- l-yl)pyrimidine dihydrochloride used as a starting material was prepared as follows :- Under an atmosphere of nitrogen, a mixture of 2-trifluoromethyl- 1 H-benzimidazole(2 g), 2,4-dichloro-6-morpholinopyrimidine (2.79 g), sodium bicarbonate (4 g) and DMA (28 ml) was heated to 110C in a sealed vessel in a microwave oven for 18 hours. The reaction mixture was heated to 140C for 20 hours and to 160C for 48 hours. The solvent was evaporated from the resultant reaction mixture. The residue was partitioned between ethyl acetate and water. The organic solution was washed in turn with water and with a saturated aqueous sodium chloride solution. The organic solution was dried over anhydrous sodium sulphate and evaporated. The resultant product was purified using a Waters ‘Xterra’ preparative reversed-phase column (5 microns silica, 19 mm diameter, 100 mm length) and decreasingly polar mixtures of a 1% solution of ammonium hydroxide (d=0.88) in water and acetonitrile as eluent. There was thus obtained 4-chloro-6-morpholino-2-(2-trifluoromethylbenzimidazol-l-yl)pyrimidine (0.65 e): NMR Spectrum: (DMSOd6) 3.75 (s, 8H), 7.18 (s, IH), 7.5 (t, IH), 7.6 (t, IH), 7.94 (d, IH), 8.12 (d, IH): Mass Spectrum:M+H” 384.

The synthetic route of 312-73-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; GRIFFEN, Edward, Jolyon; PASS, Martin; WO2008/32028; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of 312-73-2, These common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of this chloromethyl ester (1.8 mmol) in N,N-dimethylformamide (4 ml) was treated with the 2-substituted benzimidazoles (1.8 mmol) and cesium carbonate (2.8 mmol). The mixture was stirred for 3 h at r.t. and partitioned with water and ethyl acetate (20 ml). The aqueous layer was further extracted with ethyl acetate (20 ml) and the combined organic layers washed with brine (20 ml), dried (sodium sulfate), filtered and concentrated. Flash chromatography with ethyl acetate provided the desired product as colored oil.

Statistics shows that 2-(Trifluoromethyl)-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 312-73-2.

Reference:
Article; Sengupta, Prabal; Puri, Chetan S.; Chokshi, Hemant A.; Sheth, Chetana K.; Midha, Ajay S.; Chitturi, Trinadha Rao; Thennati, Rajamannar; Murumkar, Prashant R.; Yadav, Mange Ram; European Journal of Medicinal Chemistry; vol. 46; 11; (2011); p. 5549 – 5555;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 312-73-2,Some common heterocyclic compound, 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H5F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A stirred mixture of 2-Trifluoromethyl-1 H-benzoimidazole (4.92g, 26.4 mmol), 4-fluorobenaldehyde (3.1 mL, 29.1 mmol), and K2CO3 (4.37g, 31.7 mmol) in DMF (50 mL) was heated to 150 0C for 16 h. After being cooled to room temperature, the reaction mixture was partitioned between H2O and EtOAC. After usual workup, the crude product was purified by silica gel chromatography (20% Hexane/EtOAc to 30% Hexane/EtOAc) to afford a yellow oil which was subjected to a second silica gel chromatography (DMC) to provide the aldehyde intermediate 4-(2-Trifluoromethyl-benzoimidazol-1-yl)- benzaldehyde as a white solid (4.0 g).To a solution of the above 4-(2-Trifluoromethyl-benzoimidazol-1-yl)- benzaldehyde (0.155g, 0.53 mmol) and (2,3-Difluoro-phenyl)-acetonttrile (83 mg, 0.54 mmol) in EtOH (5 mL) was added a solution of KOH (0.2g) in H2O (0.5 mL). The mixture was then stirred at rt for 1h, partitioned between EtOAc/H2theta. The organic layer was dried and concentrated followed by silica gel chromatography (20% Hexane/EtOAc) to afford the product Compound 47 as a colorless oil.To a stirred solution of 4-(2-Trifluoromethyl-benzoimidazol-1-yl)-benzaldehyde (0.58 g, 2 mmol) in acetone (25 mL) was added Jone’s reagent (1.0 mL, 2.0 M) at O0C. After stirring at room temperature for 2h, the mixture was partitioned between EtOAc and saturated NaHCO3 solution. After usual workup, the crude material was separated by silica gel chromatography (50% Hexane/EtOAc to EtOAc) to afford the intermediate acid 4-(2-Trifluoromethyl- benzoimidazol-1-yl)-benzoic acid as a while solid (490 mg).To a stirred solution of 4-(2-Trifluoromethyl-benzoirnidazol-1-yl)-benzoic acid (102 mg, 0.33 mmol) in dry CHCI3 (15 mL) was added oxalyl chloride (0.09 mL) followed by one drop of DMF at room temperature. After 1h, the reaction pot was concentrated and vacuum dried. Dry chloroform (15 mL) and pyridine (0.1 mL) was then added followed by the addition of 2,3-difluoroaniHine (36 mg, 0.28 mmol). The reaction was monitored by TLC, after completion, the mixture was partitioned between 1 N HCI and DCM. Organic layer was separated and dried (Na2SO4). Removal of solvents followed silica gel chromatography (20% hexane/EtOAc) afforded the product Compound 46 as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(Trifluoromethyl)-1H-benzo[d]imidazole, its application will become more common.

Related Products of 312-73-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 312-73-2 name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-(trifluoromethyl)-1H-benzo[d]imidazole (2 g, 10.7 mmol) in H2SO4 (55.2 g, 30 mL, 535 mmol) was added slowly hydrogen peroxide (35% solution, 10.4 g, 9.41 mL, 107 mmol) at 0-5 C. The reaction mixture was stirred at 120 C. for 3 h, cooled to RT, poured into water (80 mL) under ice bath cooling and extracted with diethyl ether (3*80 mL). The combined organic phase was dried over MgSO4, filtered and evaporated to give the product as colorless solid (1.98 g, 8.84 mmol, 82.2%) which was used without further purification for the next step. MS: M=225.4 (M+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Trifluoromethyl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference of 312-73-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 3-[4-(2-bromoethoxy)phenyl]-2-ethoxypropanoate(371mg, lmmol) was dissolved in DMF (5ml) and K CO (552mg, 4mmol) was added followed by 2-trifluoromethyl benzimidazole (204mg, 1.1 mmol). The reaction mixture was heated to 6O0C for 17hrs. After the completion of the reaction, water was added and the product was extracted with Et O. The product was purified by column chromatography on silica gel using ethyl acetate and hexanes as solvent (333mg, 70%).[182][183] 1K NMR: (300MEtaz, CDCl3): delta 7.92 (d, IH), 7.68 (d, IH), 7.53-7.40 (m, 2H), 7.14(d, 2H), 6.73 (d, IH), 4.46 (t, 2H), 4.34 (t, 2H), 4.18 (q, 2H), 3.95 (t, IH), 3.63-3.60 EPO (m, IH), 3.58-3.31 (m, IH), 2.95 (t, 2H), 1.26-1.14 (m, 6H).[ 184] Mass m/z: 451.7 (M+H)

The synthetic route of 2-(Trifluoromethyl)-1H-benzo[d]imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SK CORPORATION; WO2006/104349; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem